PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18173179-2	1994	IL-1b (interleukin-1b), tumor necrosis factor alfa (TNF-a) and prostoglandin E2 (PGE2) effect on rat mesangial cell ecto-enzymes: ecto-5"-nucleotidase and ecto-Mg++-ATP-ase were investigated.	Dinoprostone	81-85	5' nucleotidase, ecto	Rattus norvegicus	130-150	
18173179-7	1994	These results indicate that induction of ecto-5"-nucleotidase activity is mainly dependent of protein synthesis and only particulary of increased PGE2 activity.	Dinoprostone	146-150	5' nucleotidase, ecto	Rattus norvegicus	41-61	
1654863-1	1991	The ecto-5"-nucleotidase activity of rat glomerular mesangial cells increases after exposure to prostaglandin E2 (PGE2) via cAMP stimulation (Savic et al., 1990, Immunology 70, 321).	Dinoprostone	96-112	5' nucleotidase, ecto	Rattus norvegicus	4-24	
1654863-1	1991	The ecto-5"-nucleotidase activity of rat glomerular mesangial cells increases after exposure to prostaglandin E2 (PGE2) via cAMP stimulation (Savic et al., 1990, Immunology 70, 321).	Dinoprostone	114-118	5' nucleotidase, ecto	Rattus norvegicus	4-24	
1654863-3	1991	Forskolin (1 microM), PGE2 (10 microM), and isoproterenol (10 microM), three products stimulating rat mesangial cell adenylate cyclase activity, enhanced cAMP accumulation within 5 min and 5"-nucleotidase activity after a lag time of at least 24 h, 3-Isobutyl-1-methylxanthine (IBMX) and Ro 20-1724, two drugs inhibiting cAMP degradation, also stimulated cAMP accumulation and 5"-nucleotidase activity.	Dinoprostone	22-26	5' nucleotidase, ecto	Rattus norvegicus	189-204	
1654863-3	1991	Forskolin (1 microM), PGE2 (10 microM), and isoproterenol (10 microM), three products stimulating rat mesangial cell adenylate cyclase activity, enhanced cAMP accumulation within 5 min and 5"-nucleotidase activity after a lag time of at least 24 h, 3-Isobutyl-1-methylxanthine (IBMX) and Ro 20-1724, two drugs inhibiting cAMP degradation, also stimulated cAMP accumulation and 5"-nucleotidase activity.	Dinoprostone	22-26	5' nucleotidase, ecto	Rattus norvegicus	377-392	
2165999-9	1990	In addition, PGE2 itself produced a dose-related (0.1-10 microM) increase of 5"-nucleotidase activity with a maximum of 2.2 times basal value.	Dinoprostone	13-17	5' nucleotidase, ecto	Rattus norvegicus	77-92	
2165999-10	1990	Taken together, these results indicate that IL-1 beta, essentially, and TNF-alpha, to a lesser extent, regulate 5"-nucleotidase expression in the plasma membrane of cultured mesangial cells and that their effect depends in part on PGE2 synthesis.	Dinoprostone	231-235	5' nucleotidase, ecto	Rattus norvegicus	112-127	
2944978-4	1986	In contrast, there was a marked increase in MPM-bound 5"-nucleotidase activity at low concentrations (up to 2 mumol/l) of PGE2 and PGF2 alpha; higher concentrations (up to 10 mumol/l), however, led to a progressive inhibition of enzyme activity.	Dinoprostone	122-126	5' nucleotidase, ecto	Rattus norvegicus	54-69	
2944978-6	1986	Changes in the allosteric properties of MPM-bound 5"-nucleotidase by concanavalin A (as reflected by changes in the Hill coefficient) indicated a fluidization of the membrane induced by PGE2 and PGF2 alpha.	Dinoprostone	186-190	5' nucleotidase, ecto	Rattus norvegicus	50-65