PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31772309-0	2019	Roles of Toll-like receptor 2/4, monoacylglycerol lipase, and cyclooxygenase in social defeat stress-induced prostaglandin E2 synthesis in the brain and their behavioral relevance.	Dinoprostone	109-125	toll-like receptor 2	Mus musculus	9-31	
31141808-4	2020	Experiments using toll-like receptors 2 (TLR2)-deficient, TLR4-deficient, and NLRP3-deficient mice indicated that these 3 proteins are involved in macrophage PGE2 secretion in response to S. aureus, and lipoproteins were essential for S. aureus invasion and survival within macrophages.	Dinoprostone	158-162	toll-like receptor 2	Mus musculus	18-39	
31141808-4	2020	Experiments using toll-like receptors 2 (TLR2)-deficient, TLR4-deficient, and NLRP3-deficient mice indicated that these 3 proteins are involved in macrophage PGE2 secretion in response to S. aureus, and lipoproteins were essential for S. aureus invasion and survival within macrophages.	Dinoprostone	158-162	toll-like receptor 2	Mus musculus	41-45	
31141808-8	2020	Thus, macrophage PGE2 secretion after S. aureus infection depends on bacterial lipoprotein maturation and macrophage receptors TLR2, TLR4, and NLRP3.	Dinoprostone	17-21	toll-like receptor 2	Mus musculus	127-131	
14527510-3	2003	This study is the first report on the inhibition by prostaglandin E2 (PGE2) of TNF release from bone marrow-derived dendritic cells stimulated with lipopolysaccharide (LPS), a TLR4 ligand, or peptidoglycan, a TLR2 ligand.	Dinoprostone	52-68	toll-like receptor 2	Mus musculus	209-213	
14527510-3	2003	This study is the first report on the inhibition by prostaglandin E2 (PGE2) of TNF release from bone marrow-derived dendritic cells stimulated with lipopolysaccharide (LPS), a TLR4 ligand, or peptidoglycan, a TLR2 ligand.	Dinoprostone	70-74	toll-like receptor 2	Mus musculus	209-213	
31772309-9	2019	These results suggest that SDS induces PGE2 synthesis in subcortical regions of the brain via the MAGL-COX pathway in a TLR2/4-dependent manner, thereby leading to social avoidance.	Dinoprostone	39-43	toll-like receptor 2	Mus musculus	120-126	
31772309-4	2019	Using mice lacking TLR2 and TLR4 in combination, here we show that social defeat stress (SDS) induced the PGE2 synthesis in subcortical, but not cortical, tissues in a TLR2/4-dependent manner.	Dinoprostone	106-110	toll-like receptor 2	Mus musculus	19-23	
31772309-4	2019	Using mice lacking TLR2 and TLR4 in combination, here we show that social defeat stress (SDS) induced the PGE2 synthesis in subcortical, but not cortical, tissues in a TLR2/4-dependent manner.	Dinoprostone	106-110	toll-like receptor 2	Mus musculus	168-174	
24862376-7	2014	This occurs via TLR2-dependent upregulation of cyclooxygenase 2 (COX-2) mRNA expression and increased secretion of PGE2 .	Dinoprostone	115-119	toll-like receptor 2	Mus musculus	16-20	
24018272-6	2013	Presence of TLR2 was necessary for induction of COX-2 and production of PGE2 by S. mucilaginosus.	Dinoprostone	72-76	toll-like receptor 2	Mus musculus	12-16	
24018272-8	2013	Administration of PGE2 to TLR2(-/-) mice resulted in impaired clearance of S. mucilaginosus, suggesting a key role for COX-2-induced PGE2 production in immune response to S. mucilaginosus.	Dinoprostone	18-22	toll-like receptor 2	Mus musculus	26-30	
23869087-6	2013	Prostaglandin E2 (PGE2), which stimulates HSPC survival and proliferation, was produced by HSPCs after TLR2 stimulation, suggesting that TLR2/MyD88 activation promotes granulopoiesis in part by production and autocrine activity of PGE2.	Dinoprostone	0-16	toll-like receptor 2	Mus musculus	103-107	
23869087-6	2013	Prostaglandin E2 (PGE2), which stimulates HSPC survival and proliferation, was produced by HSPCs after TLR2 stimulation, suggesting that TLR2/MyD88 activation promotes granulopoiesis in part by production and autocrine activity of PGE2.	Dinoprostone	0-16	toll-like receptor 2	Mus musculus	137-141	
23869087-6	2013	Prostaglandin E2 (PGE2), which stimulates HSPC survival and proliferation, was produced by HSPCs after TLR2 stimulation, suggesting that TLR2/MyD88 activation promotes granulopoiesis in part by production and autocrine activity of PGE2.	Dinoprostone	18-22	toll-like receptor 2	Mus musculus	103-107	
23869087-6	2013	Prostaglandin E2 (PGE2), which stimulates HSPC survival and proliferation, was produced by HSPCs after TLR2 stimulation, suggesting that TLR2/MyD88 activation promotes granulopoiesis in part by production and autocrine activity of PGE2.	Dinoprostone	18-22	toll-like receptor 2	Mus musculus	137-141	
23869087-6	2013	Prostaglandin E2 (PGE2), which stimulates HSPC survival and proliferation, was produced by HSPCs after TLR2 stimulation, suggesting that TLR2/MyD88 activation promotes granulopoiesis in part by production and autocrine activity of PGE2.	Dinoprostone	231-235	toll-like receptor 2	Mus musculus	137-141	
23869087-7	2013	Pretreatment of TLR2- or MyD88-deficient HSPCs with PGE2 rescued granulocytic differentiation in vivo.	Dinoprostone	52-56	toll-like receptor 2	Mus musculus	16-20	
23869087-9	2013	lin-/Sca-1+/c-kit+ cells deficient in TLR2 or MyD88 produced PMNs after PGE2 treatment when transferred into uninfected wounds.	Dinoprostone	72-76	toll-like receptor 2	Mus musculus	38-42	
23869087-10	2013	We conclude that granulopoiesis in S aureus-infected wounds is induced by TLR2/MyD88 activation of HSPCs through a mechanism that involves autocrine production and activity of PGE2.	Dinoprostone	176-180	toll-like receptor 2	Mus musculus	74-78