PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12846004-0 2003 Selective inhibition of cyclooxygenase-2 (COX-2) reduces prostaglandin E2 production and attenuates systemic disease sequelae in experimental pancreatitis. Dinoprostone 57-73 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 24-40 12846004-0 2003 Selective inhibition of cyclooxygenase-2 (COX-2) reduces prostaglandin E2 production and attenuates systemic disease sequelae in experimental pancreatitis. Dinoprostone 57-73 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 42-47 12846004-10 2003 RESULTS: Animals treated with the selective COX-2 inhibitor had significantly lower prostaglandin E2 values (211 +/- 17 vs. 366 +/- 37 and 435 +/- 13 pg/mL), produced more urine (18 +/- 4 vs. 13 +/- 3 and 12 +/- 3 mL/6-24 h) and had significantly fewer episodes of respiratory distress (defined as a pO2 < 80 mmHg or pCO2 > 50 mmHg for > 15 min; 12 vs. 57 and 71%) during the observation period than animals without or with nonselective COX inhibition. Dinoprostone 84-100 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 44-49 12846004-11 2003 CONCLUSIONS: Selective inhibition of COX-2 reduces prostaglandin E2 serum levels in this model of acute pancreatitis. Dinoprostone 51-67 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 37-42 12388434-4 2002 Four hours later, colonic temperature was measured, their cerebrospinal fluid (CSF) was sampled for PGE(2) assay, and their brains were processed for immunohistochemistry of cyclooxygenase-2, an enzyme involved in PGE(2) biosynthesis. Dinoprostone 214-220 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 174-190 12707354-0 2003 Microsomal prostaglandin E synthase-1 is a major terminal synthase that is selectively up-regulated during cyclooxygenase-2-dependent prostaglandin E2 production in the rat adjuvant-induced arthritis model. Dinoprostone 134-150 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 107-123 12672535-0 2003 Cyclooxygenase-2 mediates platelet-activating factor-induced prostaglandin E2 release from rat primary astrocytes. Dinoprostone 61-77 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 0-16 12562859-7 2003 EPA and DHA also abolished proinflammatory prostaglandin PGE2 production by inhibiting the IL1 beta-induced production of cyclooxygenase-2 (COX-2) mRNA. Dinoprostone 57-61 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 122-138 12562859-7 2003 EPA and DHA also abolished proinflammatory prostaglandin PGE2 production by inhibiting the IL1 beta-induced production of cyclooxygenase-2 (COX-2) mRNA. Dinoprostone 57-61 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 140-145 12490607-2 2003 The purpose of the present study was to pharmacologically inhibit cyclooxygenase-2 (COX-2) and inducible NO synthase (iNOS) to 1) explore the prostaglandin contribution to blood-cerebrospinal fluid barrier permeability alterations and 2) elucidate the in vivo concentration relationship between prostaglandin E2 (PGE2) and NO during experimental meningitis. Dinoprostone 295-311 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 66-82 12490607-2 2003 The purpose of the present study was to pharmacologically inhibit cyclooxygenase-2 (COX-2) and inducible NO synthase (iNOS) to 1) explore the prostaglandin contribution to blood-cerebrospinal fluid barrier permeability alterations and 2) elucidate the in vivo concentration relationship between prostaglandin E2 (PGE2) and NO during experimental meningitis. Dinoprostone 295-311 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 84-89 12490607-2 2003 The purpose of the present study was to pharmacologically inhibit cyclooxygenase-2 (COX-2) and inducible NO synthase (iNOS) to 1) explore the prostaglandin contribution to blood-cerebrospinal fluid barrier permeability alterations and 2) elucidate the in vivo concentration relationship between prostaglandin E2 (PGE2) and NO during experimental meningitis. Dinoprostone 313-317 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 66-82 12490607-2 2003 The purpose of the present study was to pharmacologically inhibit cyclooxygenase-2 (COX-2) and inducible NO synthase (iNOS) to 1) explore the prostaglandin contribution to blood-cerebrospinal fluid barrier permeability alterations and 2) elucidate the in vivo concentration relationship between prostaglandin E2 (PGE2) and NO during experimental meningitis. Dinoprostone 313-317 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 84-89 12490607-14 2003 The in vivo concentration relationship between PGE2 and NO is biphasic, suggesting that inhibition of COX-2 alone may promote NO toxicity through enhanced NO synthesis. Dinoprostone 47-51 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 102-107 12388434-7 2002 There was a significant correlation between PGE(2) level in CSF and the number of cyclooxygenase-2-positive endothelial cells. Dinoprostone 44-50 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 82-98 12523593-11 2002 CONCLUSION: The findings demonstrate comparable beneficial effects of the cox-2 selective antisense oligonucleotide and meloxicam, which seem to be mediated by a combined inhibition of both PGE2 and TNF-alpha in the present models of colitis. Dinoprostone 190-194 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 74-79 12183639-1 2002 Prostaglandin E(2) (PGE(2)) is the major prostaglandin produced both centrally and in the periphery in models of acute and chronic inflammation, and its formation in both locations is blocked by cyclooxygenase-2 (COX-2) inhibitors such as celecoxib. Dinoprostone 0-18 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 195-211 12558194-12 2002 CONCLUSION: Together these results provide consistent evidence indicating that the selective COX-2 inhibitors CLX and RFX, in contrast to DEX, INDO or SC-560, despite reducing greatly the Cg-induced pleural exudation, PGE2 content and paw oedema have only partial acute anti-inflammatory properties in two different rat acute models of inflammation. Dinoprostone 218-222 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 93-98 12482118-6 2002 COX-2 forms PGH2, which can be isomerized to PGD2, PGE2, and PGF2alpha by enzymatic and non-enzymatic mechanisms. Dinoprostone 51-55 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 0-5 12183639-1 2002 Prostaglandin E(2) (PGE(2)) is the major prostaglandin produced both centrally and in the periphery in models of acute and chronic inflammation, and its formation in both locations is blocked by cyclooxygenase-2 (COX-2) inhibitors such as celecoxib. Dinoprostone 0-18 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 213-218 12183639-1 2002 Prostaglandin E(2) (PGE(2)) is the major prostaglandin produced both centrally and in the periphery in models of acute and chronic inflammation, and its formation in both locations is blocked by cyclooxygenase-2 (COX-2) inhibitors such as celecoxib. Dinoprostone 20-26 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 195-211 12183639-1 2002 Prostaglandin E(2) (PGE(2)) is the major prostaglandin produced both centrally and in the periphery in models of acute and chronic inflammation, and its formation in both locations is blocked by cyclooxygenase-2 (COX-2) inhibitors such as celecoxib. Dinoprostone 20-26 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 213-218 12428674-4 2002 PGE2 levels increased rapidly following treatment with fsAbeta, an effect that was prevented by SB202190, a selective inhibitor of p38 mitogen-activated protein kinase (p38 MAPK), and by NS-398, which preferentially inhibits cyclooxygenase-2 (COX-2) compared to COX-1. Dinoprostone 0-4 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 225-241 12204293-1 2002 Brain endothelial cells are hypothesized to be the major source of prostaglandin E(2) (PGE(2)) responsible for fever because they express 2 PGE(2)-synthesizing enzymes (cyclooxygenase-2 and microsomal-type PGE synthase) in response to pyrogens. Dinoprostone 67-85 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 169-185 12428691-6 2002 Partial inhibition of misoprostol-induced increase in the level of COX-2 protein by indomethacin or SC-58236 may indicate the modulatory roles of endogenous prostaglandins (PGs, especially, PGE2) on the COX-2 expression. Dinoprostone 190-194 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 67-72 12428674-4 2002 PGE2 levels increased rapidly following treatment with fsAbeta, an effect that was prevented by SB202190, a selective inhibitor of p38 mitogen-activated protein kinase (p38 MAPK), and by NS-398, which preferentially inhibits cyclooxygenase-2 (COX-2) compared to COX-1. Dinoprostone 0-4 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 243-248 12090811-6 2002 Lithium also reduced the brain protein level and activity of cyclooxygenase 2, as well as the brain concentration of prostaglandin E(2), an arachidonate metabolite produced via cyclooxygenase 2. Dinoprostone 117-135 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 177-193 11453100-10 2001 In addition the expression of cyclooxygenase-2 and inducible nitric oxide synthase proteins increased PGE2 generation and NOx secretion in the ulcerated stomach were suppressed by FR167653. Dinoprostone 102-106 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 30-46 11820457-8 2001 In TNBS-induced acute inflammation of the colon, nimesulide reduced the formation of inflammatory edema, probably by a mechanism related to inhibition of PGE2 production by COX-2 pathway. Dinoprostone 154-158 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 173-178 11918320-1 2002 Cyclooxygenase-2 (COX-2), the inducible isoform of COX, has been identified as the key enzyme to regulate prostaglandin E2 synthesis in inflammatory conditions. Dinoprostone 106-122 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 0-16 11918320-1 2002 Cyclooxygenase-2 (COX-2), the inducible isoform of COX, has been identified as the key enzyme to regulate prostaglandin E2 synthesis in inflammatory conditions. Dinoprostone 106-122 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 18-23 14588302-17 2001 CONCLUSION: Administration of a selective COX-2 inhibitor after injury results in a decrease of PGE2 and TxB2 concentrations in the injured spinal cord. Dinoprostone 96-100 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 42-47 11487607-0 2001 The acute antihyperalgesic action of nonsteroidal, anti-inflammatory drugs and release of spinal prostaglandin E2 is mediated by the inhibition of constitutive spinal cyclooxygenase-2 (COX-2) but not COX-1. Dinoprostone 97-113 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 167-183 11487607-0 2001 The acute antihyperalgesic action of nonsteroidal, anti-inflammatory drugs and release of spinal prostaglandin E2 is mediated by the inhibition of constitutive spinal cyclooxygenase-2 (COX-2) but not COX-1. Dinoprostone 97-113 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 185-190 11350917-4 2001 Levels of inducible COX-2, as reflected by prostaglandin E(2) production by blood leukocytes, were measured ex vivo. Dinoprostone 43-61 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 20-25 11306620-8 2001 Inhibition of cyclooxygenase-2 activity resulted in suppression of both PGE(2) level in the CSF and fever (Cao et al., 1997), suggesting that the two enzymes were functionally linked and that this link is essential for fever. Dinoprostone 72-78 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 14-30 11306620-9 2001 These results demonstrate that brain endothelial cells play an essential role in the PGE(2) production during fever by expressing COX-2 and mPGES. Dinoprostone 85-91 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 130-135 11334856-5 2001 Lipopolysaccharide increases prostaglandin E(2) synthesis by increasing cyclooxygenase-2 protein levels in rat bladder and prostaglandin E(2) synthesis may be further elevated by increases in nitric oxide caused by an up-regulation of inducible nitric oxide synthase (iNOS). Dinoprostone 29-47 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 72-88 11285187-1 2001 Recent studies have demonstrated that overexpression of cyclooxygenase-2 (COX-2) and elevation of COX-2-mediated synthesis of prostaglandin E(2) (PGE(2)) were observed in various cancers including esophageal cancer, but their roles in carcinogenesis of the esophagi still remain unclear. Dinoprostone 126-144 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 98-103 11283850-4 2001 Addition to the cell cultures of PGE(2) promoted the release of MMPs through a mechanism that involved the expression of COX-2 and the synthesis of additional PGs. Dinoprostone 33-39 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 121-126 11274225-9 2001 The increase in COX-2 protein expression was associated with a twofold increase in prostaglandin E(2) formation by cortical microsomes obtained from ADX rats, compared with sham-operated rats. Dinoprostone 83-101 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 16-21 11964522-8 2001 MLX injected peripherally blocked COX-2-derived PGE(2) production in the MBH and AP, whereas AG injected peripherally or i.c.v. Dinoprostone 48-54 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 34-39 10807497-0 2000 Augmented prostaglandin E2 generation resulting from increased activities of cytosolic and secretory phospholipase A2 and induction of cyclooxygenase-2 in interleukin-1 beta-stimulated rat calvarial cells during the mineralizing phase. Dinoprostone 10-26 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 135-151 11046152-5 2000 The COX-2-dependent stimulation of DLC expression was, at least in part, mediated by prostaglandin E(2). Dinoprostone 85-103 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 4-9 10433392-7 1999 This greater ability from the older rGF cells to produce PGE2 and IL-1beta was due to higher mRNA levels of cyclooxygenase 2 and IL-1beta, respectively. Dinoprostone 57-61 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 108-124 10642277-10 2000 The COX-2-specific inhibitor NS-398 attenuated Ang II-stimulated DNA and protein synthesis, as well as PGE(2) production by VSMCs. Dinoprostone 103-109 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 4-9 10636620-0 2000 Inhibition of cyclooxygenase 2 by nimesulide decreases prostaglandin E2 formation but does not alter brain edema or clinical recovery after closed head injury in rats. Dinoprostone 55-71 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 14-30 9815044-5 1998 A selective COX-2 inhibitor inhibited increased PGE2 production by the ulcerated tissue. Dinoprostone 48-52 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 12-17 10193662-2 1999 TPA also increased the levels of mRNA for cyclooxygenase-2 and inducible nitric oxide synthase, suggesting that the increase in the production of prostaglandin E2 and nitric oxide is due to the increase in the levels of mRNA for cyclooxygenase-2 and inducible nitric oxide synthase, respectively. Dinoprostone 146-162 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 42-94 10193662-2 1999 TPA also increased the levels of mRNA for cyclooxygenase-2 and inducible nitric oxide synthase, suggesting that the increase in the production of prostaglandin E2 and nitric oxide is due to the increase in the levels of mRNA for cyclooxygenase-2 and inducible nitric oxide synthase, respectively. Dinoprostone 146-162 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 229-281 10193662-5 1999 These findings indicate that the inhibition by auranofin of the TPA-stimulated production of prostaglandin E2 and nitric oxide is due to the decrease in the levels of mRNA for cyclooxygenase-2 and inducible nitric oxide synthase, respectively, and the interaction of the production between prostaglandin E2 and nitric oxide may partly be involved in the mechanism for the inhibition by auranofin of the production of both prostaglandin E2 and nitric oxide. Dinoprostone 93-109 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 176-228 10465460-0 1999 The intraspinal release of prostaglandin E2 in a model of acute arthritis is accompanied by an up-regulation of cyclo-oxygenase-2 in the spinal cord. Dinoprostone 27-43 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 112-129 10465460-11 1999 The results show that there is a tonic release of immunoreactive prostaglandin E2 from the spinal cord following the induction of arthritis, which is accompanied by enhanced expression of cyclo-oxygenase-2 protein in the spinal cord. Dinoprostone 65-81 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 188-205 9887088-5 1999 COX-2 expression increased in a time-dependent manner after stretch, with maximal mRNA and protein levels occurring after 4 h. PGE2 levels increased more than 40-fold in the culture media after stretch, consistent with increased COX activity, and this was reduced to near completion in the presence of a COX-2 inhibitor, NS-398. Dinoprostone 127-131 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 0-5 9887088-5 1999 COX-2 expression increased in a time-dependent manner after stretch, with maximal mRNA and protein levels occurring after 4 h. PGE2 levels increased more than 40-fold in the culture media after stretch, consistent with increased COX activity, and this was reduced to near completion in the presence of a COX-2 inhibitor, NS-398. Dinoprostone 127-131 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 304-309 9832215-3 1998 After 4 h of reperfusion, the infarct volume and the hemispheric concentration of prostaglandin E2 (PGE2), a major substance produced by COX2, were assessed. Dinoprostone 100-104 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 137-141 9863662-6 1998 The expression of COX-2 was determined at the mRNA, protein and enzyme activity levels using Northern and Western blot, and following the synthesis of prostaglandin E2, respectively. Dinoprostone 151-167 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 18-23 9653772-10 1998 These results suggest that PGE2 may be produced by PGHS-2 in the inflammatory site, and may play a more prominent role than PGI2 in plasma exudation. Dinoprostone 27-31 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 51-57 9729377-8 1998 Media accumulation of NO2- and PGE2 was inhibited by Tau-Cl in a concentration dependent manner and this was accompanied by decreased amounts of iNOS and COX-2 proteins in cell lysates. Dinoprostone 31-35 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 154-159 9724813-6 1998 Cerebral ischemia increased the concentration of the COX-2 reaction product prostaglandin E2 (PGE2) in the ischemic area and in the ipsilateral olfactory bulb. Dinoprostone 76-92 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 53-58 9724813-6 1998 Cerebral ischemia increased the concentration of the COX-2 reaction product prostaglandin E2 (PGE2) in the ischemic area and in the ipsilateral olfactory bulb. Dinoprostone 94-98 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 53-58 9705357-4 1998 The increased expression of COX-2 was accompanied by increased prostaglandin E2 production. Dinoprostone 63-79 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 28-33 9600662-2 1998 In rat peritoneal macrophages in culture, it markedly inhibited cyclooxygenase-2-dependent prostaglandin E2 production and weakly inhibited cyclooxygenase-1-dependent prostaglandin E2 production, as did the selective cyclooxygenase-2 inhibitor NS-398 ([N-2(cyclohexyloxy-4-nitrophenyl)]-methanesulfonamide). Dinoprostone 91-107 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 64-80 9430720-0 1998 Cytosolic phospholipase A2 is required for cytokine-induced expression of type IIA secretory phospholipase A2 that mediates optimal cyclooxygenase-2-dependent delayed prostaglandin E2 generation in rat 3Y1 fibroblasts. Dinoprostone 167-183 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 132-148 9182946-0 1997 Up-regulation of cyclooxygenase-2 expression in cultured microglia by prostaglandin E2, cyclic AMP and non-steroidal anti-inflammatory drugs. Dinoprostone 70-86 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 17-33 9399978-0 1997 Inhibition of cyclooxygenase-2 rapidly reverses inflammatory hyperalgesia and prostaglandin E2 production. Dinoprostone 78-94 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 14-30 9399978-1 1997 PGs derived from cyclooxygenase-2 (COX-2), in particular PGE2, play important roles in the initiation of inflammation and pain. Dinoprostone 57-61 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 17-33 9399978-1 1997 PGs derived from cyclooxygenase-2 (COX-2), in particular PGE2, play important roles in the initiation of inflammation and pain. Dinoprostone 57-61 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 35-40 9399978-2 1997 In the present study, we evaluated the role of COX-2-derived PGE2 in an animal model of established hyperalgesia. Dinoprostone 61-65 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 47-52 9399978-13 1997 These studies suggest that continuous production of PGE2 by the COX-2 enzyme is a critical element in sustaining the hyperalgesic response at sites of tissue inflammation. Dinoprostone 52-56 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 64-69 9182946-4 1997 Exogenous prostaglandin E2 (PGE2), which elevates the cAMP level in microglial cells, also increased the lipopolysaccharide-induced expression of cyclooxygenase-2 and production of thromboxane in a dose- and time-dependent manner. Dinoprostone 10-26 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 146-162 9182946-4 1997 Exogenous prostaglandin E2 (PGE2), which elevates the cAMP level in microglial cells, also increased the lipopolysaccharide-induced expression of cyclooxygenase-2 and production of thromboxane in a dose- and time-dependent manner. Dinoprostone 28-32 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 146-162 9182946-5 1997 The observations that the lipopolysaccharide-induced prostanoid production was specifically increased by 11-deoxy-16,16-dm PGE2, a selective agonist at the PGE2 receptor EP2 coupled to the activation of adenylyl cyclase, and that the enhancing effect of PGE2 was partially prevented by specific inhibitors of adenylyl cyclase and protein kinase A, suggest that the up-regulation of cyclooxygenase-2 expression by PGE2 is mediated by cAMP, through a putative microglial EP2 receptor. Dinoprostone 123-127 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 382-398 9182946-5 1997 The observations that the lipopolysaccharide-induced prostanoid production was specifically increased by 11-deoxy-16,16-dm PGE2, a selective agonist at the PGE2 receptor EP2 coupled to the activation of adenylyl cyclase, and that the enhancing effect of PGE2 was partially prevented by specific inhibitors of adenylyl cyclase and protein kinase A, suggest that the up-regulation of cyclooxygenase-2 expression by PGE2 is mediated by cAMP, through a putative microglial EP2 receptor. Dinoprostone 156-160 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 382-398 9182946-5 1997 The observations that the lipopolysaccharide-induced prostanoid production was specifically increased by 11-deoxy-16,16-dm PGE2, a selective agonist at the PGE2 receptor EP2 coupled to the activation of adenylyl cyclase, and that the enhancing effect of PGE2 was partially prevented by specific inhibitors of adenylyl cyclase and protein kinase A, suggest that the up-regulation of cyclooxygenase-2 expression by PGE2 is mediated by cAMP, through a putative microglial EP2 receptor. Dinoprostone 156-160 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 382-398 9182946-7 1997 In conclusion, while the strong up-regulation of cyclooxygenase-2 expression by exogenous PGE2 appears to be mediated by EP2 receptors and cAMP, the limited down-regulation caused by anti-inflammatory drug treatments may be either due to arachidonic acid metabolites other than PGE2, or to PGE2 itself, acting through a distinct cAMP-independent signalling pathway. Dinoprostone 90-94 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 49-65 9182946-7 1997 In conclusion, while the strong up-regulation of cyclooxygenase-2 expression by exogenous PGE2 appears to be mediated by EP2 receptors and cAMP, the limited down-regulation caused by anti-inflammatory drug treatments may be either due to arachidonic acid metabolites other than PGE2, or to PGE2 itself, acting through a distinct cAMP-independent signalling pathway. Dinoprostone 278-282 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 49-65 9182946-7 1997 In conclusion, while the strong up-regulation of cyclooxygenase-2 expression by exogenous PGE2 appears to be mediated by EP2 receptors and cAMP, the limited down-regulation caused by anti-inflammatory drug treatments may be either due to arachidonic acid metabolites other than PGE2, or to PGE2 itself, acting through a distinct cAMP-independent signalling pathway. Dinoprostone 278-282 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 49-65 9020023-0 1997 Concordant induction of prostaglandin E2 synthase with cyclooxygenase-2 leads to preferred production of prostaglandin E2 over thromboxane and prostaglandin D2 in lipopolysaccharide-stimulated rat peritoneal macrophages. Dinoprostone 24-40 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 55-71 9152412-0 1997 Prostaglandin E2 production dependent upon cyclooxygenase-1 and cyclooxygenase-2 and its contradictory modulation by auranofin in rat peritoneal macrophages. Dinoprostone 0-16 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 64-80 8954137-4 1996 By analyzing COX-2 mRNA level by Northern blot and COX-2 enzyme mass and phosphotyrosine by Western blot, it was revealed that the increase of PGE2 production reflected the induction of COX-2 expression through activation of tyrosine kinase. Dinoprostone 143-147 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 13-18 9014225-0 1996 Effects of non-steroidal anti-inflammatory drugs on prostaglandin E2 production by cyclooxygenase-2 from endogenous and exogenous arachidonic acid in rat peritoneal macrophages stimulated with lipopolysaccharide. Dinoprostone 52-68 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 83-99 9014225-4 1996 NSAIDs inhibited PGE2 production from exogenous AA mediated by both COX-1 and COX-2. Dinoprostone 17-21 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 78-83 9014225-7 1996 These data suggest that PGE2 production through COX-2 from exogenous AA may not be subject to the same regulatory processes as that from endogenous AA and the two metabolic processes may be differentially sensitive to different NSAIDs. Dinoprostone 24-28 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 48-53 8954137-4 1996 By analyzing COX-2 mRNA level by Northern blot and COX-2 enzyme mass and phosphotyrosine by Western blot, it was revealed that the increase of PGE2 production reflected the induction of COX-2 expression through activation of tyrosine kinase. Dinoprostone 143-147 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 51-56 8954137-4 1996 By analyzing COX-2 mRNA level by Northern blot and COX-2 enzyme mass and phosphotyrosine by Western blot, it was revealed that the increase of PGE2 production reflected the induction of COX-2 expression through activation of tyrosine kinase. Dinoprostone 143-147 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 51-56 8900441-8 1996 The selective PGHS-2 inhibitors NS-398, nimesulide and SC-58125 suppressed the inflammatory reaction and caused a marked decrease in the level of PGE2 but not in those of TXB2 and 6-keto-PGF 1 alpha. Dinoprostone 146-150 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 14-20 8662662-6 1996 In contrast, PDTC inhibited Cox-2 expression at the post-transcriptional level, since PDTC did not affect IL-1beta-induced Cox-2 mRNA levels but inhibited Cox-2 protein expression and prostaglandin E2 production. Dinoprostone 184-200 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 28-33 8573101-7 1996 Prostaglandin E2, known to be an intracellular physiological trigger of cAMP formation, stimulated only cyclooxygenase 2 expression and activity at a concentration of 10 microM, and not inducible NO synthase. Dinoprostone 0-16 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 104-120 8891309-1 1996 We previously showed that intraperitoneal injection of lipopolysaccharide induced cyclooxygenase-2 (COX-2) mRNA in as yet unidentified cells of blood vessels and leptomeninges in the rat brain and proposed a possible role of these cells as the source of prostaglandin E2 in the genesis of fever (Cao et al., Brain Res., 697 (1995) 187-196). Dinoprostone 254-270 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 82-98 8891309-1 1996 We previously showed that intraperitoneal injection of lipopolysaccharide induced cyclooxygenase-2 (COX-2) mRNA in as yet unidentified cells of blood vessels and leptomeninges in the rat brain and proposed a possible role of these cells as the source of prostaglandin E2 in the genesis of fever (Cao et al., Brain Res., 697 (1995) 187-196). Dinoprostone 254-270 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 100-105 8891309-7 1996 These results imply that circulating IL-1 beta acts on its receptor on the endothelial cells of the brain vasculature to induce COX-2 mRNA, which is possibly responsible for the elevated level of PGE2 seen during fever. Dinoprostone 196-200 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 128-133 8898352-8 1996 These data show for the first time a regulation of sPLA2I and PGHS2 expression by PRL and may indicate that, in uterine cells, PRL enhances the PGE2 release and production by increasing the expression of both sPLA2I and PGHS2. Dinoprostone 144-148 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 62-67 8898352-8 1996 These data show for the first time a regulation of sPLA2I and PGHS2 expression by PRL and may indicate that, in uterine cells, PRL enhances the PGE2 release and production by increasing the expression of both sPLA2I and PGHS2. Dinoprostone 144-148 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 220-225 8987571-8 1996 This increase of PGE2 production was consistent with a 3.3- to 9.5-fold elevation of inducible prostaglandin G/H synthase-2 (PGHS-2) mRNA, quantitated by reverse transcription-polymerase chain reaction (RT-PCR). Dinoprostone 17-21 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 125-131 8900441-7 1996 Thus, the changes of the level of PGE2 were closely paralleled those of PGHS-2. Dinoprostone 34-38 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 72-78 8900441-9 1996 These results suggest that the PGHS-2 expressed in the pleural exudate cells may be involved in PGE2 formation at the site of inflammation. Dinoprostone 96-100 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 31-37 8077206-3 1994 ET-1 induction of PGHS-2 protein was accompanied by a sustained enhancement of enzymatic activity assessed by conversion of arachidonic acid to prostaglandin E2. Dinoprostone 144-160 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 18-24 7732815-0 1995 Endothelin regulates PGE2 formation in rat mesangial cells through induction of prostaglandin endoperoxide synthase-2. Dinoprostone 21-25 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 80-117 34610503-0 2021 Prostaglandin E2 increases the expression of cyclooxygenase-2 in cultured rat microglia. Dinoprostone 0-16 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 45-61 34975477-11 2021 In vivo, puerarin treatment decreased the enzyme activities of cPLA2 and COX-2, resulting in lower production of prostaglandin E2 (PGE2) in hippocampal and intestinal tissues. Dinoprostone 113-129 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 73-78 34975477-11 2021 In vivo, puerarin treatment decreased the enzyme activities of cPLA2 and COX-2, resulting in lower production of prostaglandin E2 (PGE2) in hippocampal and intestinal tissues. Dinoprostone 131-135 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 73-78 7916614-3 1993 Transfection of the rat PGHS-2 cDNA into COS 7 cells, followed by the addition of 20 microM arachidonic acid, resulted in a dramatic increase in PGE2 released from these cells. Dinoprostone 145-149 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 24-30 33801492-9 2021 In summary, the novel GPR55 receptor antagonist KIT 10 reduces neuroinflammatory parameters in microglia by inhibiting the COX-2/PGE2 pathway. Dinoprostone 129-133 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 123-128 34539838-7 2021 Furthermore, an agonist of PLA2 (melittin) and COX2 production (prostaglandin E2 (PGE2)) inhibited the basolateral Kir4.1/Kir5.1 channels. Dinoprostone 64-80 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 47-51 34539838-7 2021 Furthermore, an agonist of PLA2 (melittin) and COX2 production (prostaglandin E2 (PGE2)) inhibited the basolateral Kir4.1/Kir5.1 channels. Dinoprostone 82-86 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 47-51 34539838-8 2021 Taken together, the results of the present study suggested that the inhibitory effect of TNF-alpha on the basolateral Kir4.1/Kir5.1 channels in the TAL during diabetes is mediated by the PLA2/COX2/PGE2 signaling pathway. Dinoprostone 197-201 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 192-196 35537317-3 2022 We aimed to determine how adolescent-onset alcohol drinking affects pro-inflammatory mediators endothelin-1 (ET-1), cyclooxygenase-2 (COX-2), and prostaglandin E2 (PGE2) in the brain and the role of COX-2 and PGE2 in EtOH reinstatement in adolescent females. Dinoprostone 164-168 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 199-204 34764879-9 2021 The benefits of exercise were related with the downregulation of p38-mitogen-activated protein kinase (MAPK), and the subsequent inhibition of the pathways of the cyclooxygenase 2 (COX-2) product, prostaglandin E2 (PGE2). Dinoprostone 197-213 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 163-179 34764879-9 2021 The benefits of exercise were related with the downregulation of p38-mitogen-activated protein kinase (MAPK), and the subsequent inhibition of the pathways of the cyclooxygenase 2 (COX-2) product, prostaglandin E2 (PGE2). Dinoprostone 197-213 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 181-186 34764879-9 2021 The benefits of exercise were related with the downregulation of p38-mitogen-activated protein kinase (MAPK), and the subsequent inhibition of the pathways of the cyclooxygenase 2 (COX-2) product, prostaglandin E2 (PGE2). Dinoprostone 215-219 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 163-179 34764879-9 2021 The benefits of exercise were related with the downregulation of p38-mitogen-activated protein kinase (MAPK), and the subsequent inhibition of the pathways of the cyclooxygenase 2 (COX-2) product, prostaglandin E2 (PGE2). Dinoprostone 215-219 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 181-186 33510092-0 2021 High mobility group box 1 mediates inflammatory response of astrocytes via cyclooxygenase 2/prostaglandin E2 signaling following spinal cord injury. Dinoprostone 92-108 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 75-91 33510092-5 2021 Our results showed that the HMGB1/Toll-like receptor 4 (TLR4) axis was involved in the activation of astrocyte inflammatory response through regulation of cyclooxygenase 2 (COX2)/prostaglandin E2 (PGE2) signaling. Dinoprostone 179-195 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 155-171 33510092-5 2021 Our results showed that the HMGB1/Toll-like receptor 4 (TLR4) axis was involved in the activation of astrocyte inflammatory response through regulation of cyclooxygenase 2 (COX2)/prostaglandin E2 (PGE2) signaling. Dinoprostone 179-195 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 173-177 33510092-5 2021 Our results showed that the HMGB1/Toll-like receptor 4 (TLR4) axis was involved in the activation of astrocyte inflammatory response through regulation of cyclooxygenase 2 (COX2)/prostaglandin E2 (PGE2) signaling. Dinoprostone 197-201 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 155-171 33510092-5 2021 Our results showed that the HMGB1/Toll-like receptor 4 (TLR4) axis was involved in the activation of astrocyte inflammatory response through regulation of cyclooxygenase 2 (COX2)/prostaglandin E2 (PGE2) signaling. Dinoprostone 197-201 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 173-177 33510092-9 2021 Pharmacologic blockade of TLR2/4 attenuated HMGB1-mediated activation of the COX2/PGE2 pathway. Dinoprostone 82-86 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 77-81 33510092-11 2021 Our results suggest that HMGB1 mediates the astrocyte inflammatory response through regulating the COX2/PGE2 signaling pathway. Dinoprostone 104-108 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 99-103 34089729-0 2021 Parecoxib alleviates the motor behavioral decline of aged rats by ameliorating mitochondrial dysfunction in the substantia nigra via COX-2/PGE2 pathway inhibition. Dinoprostone 139-143 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 133-138 34089729-2 2021 Cyclooxygenase 2 (COX-2), the rate-limiting enzyme in the prostaglandin E2 (PGE2) synthesis pathway, is implicated in aging and age-related neurodegenerative diseases; moreover, inhibition of COX-2 expression has been shown to be neuroprotective for nigrostriatal dopaminergic neurons. Dinoprostone 58-74 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 0-16 34089729-2 2021 Cyclooxygenase 2 (COX-2), the rate-limiting enzyme in the prostaglandin E2 (PGE2) synthesis pathway, is implicated in aging and age-related neurodegenerative diseases; moreover, inhibition of COX-2 expression has been shown to be neuroprotective for nigrostriatal dopaminergic neurons. Dinoprostone 58-74 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 18-23 34089729-2 2021 Cyclooxygenase 2 (COX-2), the rate-limiting enzyme in the prostaglandin E2 (PGE2) synthesis pathway, is implicated in aging and age-related neurodegenerative diseases; moreover, inhibition of COX-2 expression has been shown to be neuroprotective for nigrostriatal dopaminergic neurons. Dinoprostone 58-74 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 192-197 34089729-2 2021 Cyclooxygenase 2 (COX-2), the rate-limiting enzyme in the prostaglandin E2 (PGE2) synthesis pathway, is implicated in aging and age-related neurodegenerative diseases; moreover, inhibition of COX-2 expression has been shown to be neuroprotective for nigrostriatal dopaminergic neurons. Dinoprostone 76-80 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 0-16 34089729-2 2021 Cyclooxygenase 2 (COX-2), the rate-limiting enzyme in the prostaglandin E2 (PGE2) synthesis pathway, is implicated in aging and age-related neurodegenerative diseases; moreover, inhibition of COX-2 expression has been shown to be neuroprotective for nigrostriatal dopaminergic neurons. Dinoprostone 76-80 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 18-23 34089729-5 2021 We found that parecoxib administration to aged rats for 10 weeks decreased COX-2/PGE2 expression, increased tyrosine hydroxylase and dopamine transporter expression in nigrostriatal dopaminergic neurons, and alleviated motor behavioral decline. Dinoprostone 81-85 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 75-80 33049240-12 2021 These results indicate that PGE2 is synthesized by COX-2/mPGES-1 in spinal endothelial cells after nerve injury. Dinoprostone 28-32 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 51-56 34238176-12 2022 CONCLUSION: In conclusion, the current results proved that etoricoxib possesses an anticarcinogenic effect via its antioxidant, anti-inflammatory, and modulation of NF-kappaB/COX-2/PGE2 signaling. Dinoprostone 181-185 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 175-180 33359576-7 2021 At the same time, 12 months after chronic oral exposure to DU, the expression level of cyclooxygenase-2 (COX-2) and proinflammatory factor prostaglandin E2 (PGE2) in testicular tissue were increased, and the level of hnRNP A2/B1 caused by DU was decreased by reactive oxygen scavenger N-acetylcysteine (NAC). Dinoprostone 157-161 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 105-110 33228717-0 2020 The COX-2-derived PGE2 autocrine contributes to bradykinin-induced matrix metalloproteinase-9 expression and astrocytic migration via STAT3 signaling. Dinoprostone 18-22 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 4-9 33339104-3 2020 It is well-known that inducible cyclooxygenase 2 (COX-2) plays a crucial role at the beginning of the inflammatory response by converting arachidonic acid into proinflammatory prostaglandin PGE2 and then producing other proinflammatory chemokines and cytokines. Dinoprostone 176-194 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 32-48 33339104-3 2020 It is well-known that inducible cyclooxygenase 2 (COX-2) plays a crucial role at the beginning of the inflammatory response by converting arachidonic acid into proinflammatory prostaglandin PGE2 and then producing other proinflammatory chemokines and cytokines. Dinoprostone 176-194 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 50-55 33339104-5 2020 Our results reveal that during the inflammatory state, induced by intraplantar administration of carrageenan, the increase of PGE2 levels released in the paw exudates were associated with COX-2 nitration. Dinoprostone 126-130 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 188-193 33228717-4 2020 The raised BK may be detrimental effects on the CNS that may aggravate brain inflammation through MMP-9 up-regulation or cyclooxygenase-2 (COX-2)-derived prostaglandin E2 (PGE2) production in brain astrocytes. Dinoprostone 154-170 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 121-137 33228717-4 2020 The raised BK may be detrimental effects on the CNS that may aggravate brain inflammation through MMP-9 up-regulation or cyclooxygenase-2 (COX-2)-derived prostaglandin E2 (PGE2) production in brain astrocytes. Dinoprostone 154-170 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 139-144 32913950-5 2020 Blocking COX-2 activity by selective inhibitor SC-58125 prevented BDNF elevation in the hippocampus following SE; prostaglandin E2 (PGE2), a major product of COX-2 in the brain, was sufficient to stimulate hippocampal cells to secrete BDNF, suggesting that a PGE2 signaling pathway might be directly involved in hippocampal BDNF production. Dinoprostone 114-130 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 158-163 33228717-4 2020 The raised BK may be detrimental effects on the CNS that may aggravate brain inflammation through MMP-9 up-regulation or cyclooxygenase-2 (COX-2)-derived prostaglandin E2 (PGE2) production in brain astrocytes. Dinoprostone 172-176 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 121-137 33228717-4 2020 The raised BK may be detrimental effects on the CNS that may aggravate brain inflammation through MMP-9 up-regulation or cyclooxygenase-2 (COX-2)-derived prostaglandin E2 (PGE2) production in brain astrocytes. Dinoprostone 172-176 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 139-144 33228717-5 2020 However, the relationship between BK-induced MMP-9 expression and COX-2-derived PGE2 release in brain astrocytes remains unclear. Dinoprostone 80-84 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 66-71 33228717-8 2020 RESULTS: Our results show activation of native COX-2 by BK led to PGE2 production and release. Dinoprostone 66-70 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 47-52 32959405-7 2020 Further, we found that proteasome-mediated degradation of cyclooxygenase-2 (COX2, rate-limiting enzyme in PGE2 biosynthesis) in hypoxic MSCs is responsible for PGE2 decrease and loss of immunoprivilege of MSCs. Dinoprostone 106-110 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 58-74 32959405-7 2020 Further, we found that proteasome-mediated degradation of cyclooxygenase-2 (COX2, rate-limiting enzyme in PGE2 biosynthesis) in hypoxic MSCs is responsible for PGE2 decrease and loss of immunoprivilege of MSCs. Dinoprostone 106-110 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 76-80 32959405-7 2020 Further, we found that proteasome-mediated degradation of cyclooxygenase-2 (COX2, rate-limiting enzyme in PGE2 biosynthesis) in hypoxic MSCs is responsible for PGE2 decrease and loss of immunoprivilege of MSCs. Dinoprostone 160-164 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 58-74 32959405-7 2020 Further, we found that proteasome-mediated degradation of cyclooxygenase-2 (COX2, rate-limiting enzyme in PGE2 biosynthesis) in hypoxic MSCs is responsible for PGE2 decrease and loss of immunoprivilege of MSCs. Dinoprostone 160-164 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 76-80 33192558-12 2020 In conclusion, high-salt environment could induce GAG production of DFs in a COX-2/PGE2-dependent manner. Dinoprostone 83-87 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 77-82 33192558-4 2020 A link between the COX-2/PGE2 system and GAG synthesis was also suggested. Dinoprostone 25-29 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 19-24 33192558-5 2020 We hypothesized that in dermal fibroblasts (DFs) high-sodium concentration activates the COX-2/PGE2 pathway and also that PGE2 increases the production of HA. Dinoprostone 95-99 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 89-94 32162076-3 2020 Therefore, the present study was conducted to explore whether inhibition of cyclooxygenase-2 (COX-2)-derived PGE2 by celecoxib and blocking of TXA2 action by seratrodast could alter the progression of liver regeneration after 70% partial hepatectomy (PHx) in rats. Dinoprostone 109-113 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 76-92 32162076-3 2020 Therefore, the present study was conducted to explore whether inhibition of cyclooxygenase-2 (COX-2)-derived PGE2 by celecoxib and blocking of TXA2 action by seratrodast could alter the progression of liver regeneration after 70% partial hepatectomy (PHx) in rats. Dinoprostone 109-113 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 94-99 32913950-0 2020 COX-2/PGE2 axis regulates hippocampal BDNF/TrkB signaling via EP2 receptor after prolonged seizures. Dinoprostone 6-10 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 0-5 32913950-5 2020 Blocking COX-2 activity by selective inhibitor SC-58125 prevented BDNF elevation in the hippocampus following SE; prostaglandin E2 (PGE2), a major product of COX-2 in the brain, was sufficient to stimulate hippocampal cells to secrete BDNF, suggesting that a PGE2 signaling pathway might be directly involved in hippocampal BDNF production. Dinoprostone 132-136 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 158-163 32913950-5 2020 Blocking COX-2 activity by selective inhibitor SC-58125 prevented BDNF elevation in the hippocampus following SE; prostaglandin E2 (PGE2), a major product of COX-2 in the brain, was sufficient to stimulate hippocampal cells to secrete BDNF, suggesting that a PGE2 signaling pathway might be directly involved in hippocampal BDNF production. Dinoprostone 259-263 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 9-14 32913950-8 2020 Our findings suggest that COX-2 via the PGE2/EP2 pathway regulates hippocampal BDNF/TrkB activity following prolonged seizures. Dinoprostone 40-44 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 26-31 32183879-12 2020 However, MSCs had little effect on alleviating fibrosis when the fibroblasts were pretreated with cyclooxygenase-2 (COX-2) inhibitors, which also inhibited PGE2 secretion. Dinoprostone 156-160 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 98-114 31705786-15 2020 DISCUSSION: The concomitant decrease of Stra8 expression, Cox2 expression and PGE2 and PGF2a production in gonocytes co-treated with RA suggests that Cox2 plays a role in PND3 gonocyte differentiation. Dinoprostone 78-82 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 150-154 32183879-12 2020 However, MSCs had little effect on alleviating fibrosis when the fibroblasts were pretreated with cyclooxygenase-2 (COX-2) inhibitors, which also inhibited PGE2 secretion. Dinoprostone 156-160 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 116-121 31841472-14 2019 The combined effect of ionizing radiation and the COX-2 inhibitor (meloxivet) affects the level of PGE-2, VEGF, ie, the slowing of angiogenesis. Dinoprostone 99-104 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 50-55 31454071-8 2020 Cyclooxygenase 2, a key enzyme of PGE2 synthesis, was highly expressed in the granulosa cells of rats and women with the syndrome, and PGE2 concentration was increased in the follicular fluid. Dinoprostone 34-38 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 0-16 31841472-0 2019 INFLUENCE OF COMBINED ACTION OF X-RADIATION AND CYCLOOXYGENASE-2 - MELOXIVET INHIBITOR ON VEGF AND PGE-2 CONTENT IN BLOOD OF RAT-TUMOR CARRIERS. Dinoprostone 99-104 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 48-64 28119480-9 2017 Inhibition of the key signaling components in the cyclooxygenase-2 (COX-2)/prostaglandin E2 signaling cascade (phospholipase A2, COX-2, multidrug resistance protein 4, and G-protein-coupled prostaglandin E2 receptors 1 and 2), abolished P-glycoprotein induction by C1P. Dinoprostone 75-91 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 50-66 31841472-1 2019 OBJECTIVE: The objective of this work was to study the effect of the combined action of X-radiation and the cyclooxygenase-2 (COX-2) inhibitor on the level of vascular endothelial growth factor (VEGF) and prostaglandin E2 (PGE-2) in blood serum of rat-tumor carriers at irradiation in different doses. Dinoprostone 205-221 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 108-124 31841472-1 2019 OBJECTIVE: The objective of this work was to study the effect of the combined action of X-radiation and the cyclooxygenase-2 (COX-2) inhibitor on the level of vascular endothelial growth factor (VEGF) and prostaglandin E2 (PGE-2) in blood serum of rat-tumor carriers at irradiation in different doses. Dinoprostone 205-221 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 126-131 31841472-1 2019 OBJECTIVE: The objective of this work was to study the effect of the combined action of X-radiation and the cyclooxygenase-2 (COX-2) inhibitor on the level of vascular endothelial growth factor (VEGF) and prostaglandin E2 (PGE-2) in blood serum of rat-tumor carriers at irradiation in different doses. Dinoprostone 223-228 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 108-124 31841472-1 2019 OBJECTIVE: The objective of this work was to study the effect of the combined action of X-radiation and the cyclooxygenase-2 (COX-2) inhibitor on the level of vascular endothelial growth factor (VEGF) and prostaglandin E2 (PGE-2) in blood serum of rat-tumor carriers at irradiation in different doses. Dinoprostone 223-228 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 126-131 31841472-9 2019 At the same time, the level of PGE-2 also decreased with respect to iso- lated exposure by 1.5 times, indicating COX-2 inhibition. Dinoprostone 31-36 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 113-118 29678208-14 2018 CONCLUSIONS: Glial IL-1beta upregulated neuronal Nav1.7 expression via the crosstalk between signaling pathways of the glial IL-1beta/COX-2/PGE2 and the neuronal EP2/PKA/CREB/Nav1.7 in TG contributing to TMJ inflammatory hypernociception. Dinoprostone 140-144 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 134-139 29311938-1 2017 Prostaglandin E2 (PGE2) is an important bioactive lipid that accumulates after tissue damage or inflammation due to the rapid expression of cyclooxygenase 2. Dinoprostone 0-16 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 140-156 29311938-1 2017 Prostaglandin E2 (PGE2) is an important bioactive lipid that accumulates after tissue damage or inflammation due to the rapid expression of cyclooxygenase 2. Dinoprostone 18-22 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 140-156 28174214-3 2017 Previously, we demonstrated that initial burst productions of PGD2, PGE2, and PGF2alpha are produced by cyclooxygenase-2 (COX-2) in the hippocampus following a single systemic kainic acid (KA) administration. Dinoprostone 68-72 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 104-120 28174214-3 2017 Previously, we demonstrated that initial burst productions of PGD2, PGE2, and PGF2alpha are produced by cyclooxygenase-2 (COX-2) in the hippocampus following a single systemic kainic acid (KA) administration. Dinoprostone 68-72 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 122-127 28123635-5 2017 An ELISA showed that the increased inflammatory factors, such as nitrite, prostaglandin E-2 (PGE-2), IL-6 and cyclooxygenase-2 (COX-2), were decreased by the BMSC co-culture. Dinoprostone 93-98 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 128-133 28352129-11 2017 An imbalance in the cortical COX2-PGE2-cAMP/PKA-CREB-BDNF signalling pathway participates in the pathogenic mechanism of depression. Dinoprostone 34-38 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 29-33 26165557-12 2016 A detailed analysis revealed decreased proliferation and increased apoptosis of chondrocytes in the growth plate, indicating that COX-2 is responsible for PGE2 production in growth plate chondrocytes. Dinoprostone 155-159 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 130-135 27627895-5 2017 CONCLUSION: Preconditioning of MSCs with AdipoRon prior to transplantation could enhance cell survival, angiogenesis and migration via activating the COX-2/PGE2/HIF-1 pathway and other contributing factors. Dinoprostone 156-160 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 150-155 27465993-5 2016 Sulprostone decreased expression of cyclooxygenase 2 (COX-2) expression by ~75% in TAL tubules from rats given 1% NaCl concomitant with a ~60% inhibition of COX-2-dependent PGE2 levels in the kidney. Dinoprostone 173-177 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 157-162 27056726-4 2016 COX-2/prostaglandin E2 (PGE2)/EP-2/p-ERK integrated signal pathways regulated the expressions of intestinal zonula occludens-1 (ZO-1) and E-cadherin, which maintain the function of intestinal epithelial barrier. Dinoprostone 6-22 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 0-5 27056726-4 2016 COX-2/prostaglandin E2 (PGE2)/EP-2/p-ERK integrated signal pathways regulated the expressions of intestinal zonula occludens-1 (ZO-1) and E-cadherin, which maintain the function of intestinal epithelial barrier. Dinoprostone 24-28 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 0-5 26051129-10 2015 In conclusion, LPS induces COX-2 to produce PGE2, which initially activates EP2 and/or EP4 on smooth muscle cells to inhibit the contractility in early phase of LPS exposure. Dinoprostone 44-48 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 27-32 26735056-9 2015 CONCLUSION: The enhanced COX-2/ prostaglandin E2 involves in the hemorrhagic shock induced intestinal dysmotility. Dinoprostone 32-48 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 25-30 25912457-6 2015 RESULTS: Meloxicam reduced by 75% the production of prostaglandin E2 (bioproduct of COX-2) in irradiated brains validating its anti-inflammatory effect. Dinoprostone 52-68 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 84-89 26311764-0 2015 COX-2-Derived Prostaglandin E2 Produced by Pyramidal Neurons Contributes to Neurovascular Coupling in the Rodent Cerebral Cortex. Dinoprostone 14-30 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 0-5 24962643-6 2015 Moreover, LPS-induced expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) was inhibited by ALA pretreatment, and consequently, the secretion levels of their respective enzymatic products prostaglandin E2 (PGE2) and nitric oxide (NO) were significantly decreased. Dinoprostone 217-233 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 36-52 25648833-9 2015 Transcript levels of Ptgs2 and prostaglandin (PG)E2 production were increased by treatment with the Rev-erbalpha antagonist, suggesting the contribution of the nuclear receptor Rev-erbalpha to Ptgs2 expression. Dinoprostone 31-51 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 193-198 24962643-6 2015 Moreover, LPS-induced expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) was inhibited by ALA pretreatment, and consequently, the secretion levels of their respective enzymatic products prostaglandin E2 (PGE2) and nitric oxide (NO) were significantly decreased. Dinoprostone 217-233 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 54-59 24962643-6 2015 Moreover, LPS-induced expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) was inhibited by ALA pretreatment, and consequently, the secretion levels of their respective enzymatic products prostaglandin E2 (PGE2) and nitric oxide (NO) were significantly decreased. Dinoprostone 235-239 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 36-52 24962643-6 2015 Moreover, LPS-induced expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) was inhibited by ALA pretreatment, and consequently, the secretion levels of their respective enzymatic products prostaglandin E2 (PGE2) and nitric oxide (NO) were significantly decreased. Dinoprostone 235-239 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 54-59 25736434-5 2015 Here we show that MSC administration alleviated airway inflammation and emphysema through the down-regulation of cyclooxygenase-2 (COX-2) and COX-2-mediated prostaglandin E2 (PGE2) production, possibly through the effect on alveolar macrophages. Dinoprostone 157-173 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 142-147 25736434-5 2015 Here we show that MSC administration alleviated airway inflammation and emphysema through the down-regulation of cyclooxygenase-2 (COX-2) and COX-2-mediated prostaglandin E2 (PGE2) production, possibly through the effect on alveolar macrophages. Dinoprostone 175-179 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 142-147 25736434-6 2015 In vitro co-culture experiments provided evidence that MSCs down-regulated COX-2/PGE2 in macrophages through inhibition of the activation-associated phosphorylation of p38 MAPK and ERK. Dinoprostone 81-85 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 75-80 25171787-6 2014 LPS stimulated prostaglandin E2 (PGE2) production from DRG glial cells in a TLR4- and COX-2-dependent manner. Dinoprostone 15-31 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 86-91 24915969-2 2015 The deleterious effects of BK on brain astrocytes may aggravate brain inflammation mediated through the upregulation of cytosolic phospholipase A2 (cPLA2)/cyclooxygenase-2 (COX-2)-derived prostaglandin E2 (PGE2) production. Dinoprostone 188-204 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 155-171 24915969-2 2015 The deleterious effects of BK on brain astrocytes may aggravate brain inflammation mediated through the upregulation of cytosolic phospholipase A2 (cPLA2)/cyclooxygenase-2 (COX-2)-derived prostaglandin E2 (PGE2) production. Dinoprostone 206-210 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 155-171 25620059-7 2015 Genistein pre-treatment significantly inhibited the increased protein levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), thereby reducing nitric oxide (NO) and prostaglandin-E2 (PGE) levels, respectively. Dinoprostone 188-204 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 141-146 25620059-7 2015 Genistein pre-treatment significantly inhibited the increased protein levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), thereby reducing nitric oxide (NO) and prostaglandin-E2 (PGE) levels, respectively. Dinoprostone 206-209 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 141-146 25171787-6 2014 LPS stimulated prostaglandin E2 (PGE2) production from DRG glial cells in a TLR4- and COX-2-dependent manner. Dinoprostone 33-37 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 86-91 25171787-7 2014 In addition, exogenous PGE2 potentiated LPS-stimulated COX-2 mRNA while inhibiting TNFalpha mRNA expression by DRG cells, suggestive of a complex regulatory system to control inflammation within the DRG. Dinoprostone 23-27 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 55-60 24773364-2 2014 In macrophages, PGE2 production is regulated by arachidonic acid release and cyclooxygenase-2 (COX-2) expression. Dinoprostone 16-20 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 77-93 24773364-2 2014 In macrophages, PGE2 production is regulated by arachidonic acid release and cyclooxygenase-2 (COX-2) expression. Dinoprostone 16-20 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 95-100 25324681-0 2014 ERK1/2/COX-2/PGE2 signaling pathway mediates GPR91-dependent VEGF release in streptozotocin-induced diabetes. Dinoprostone 13-17 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 7-12 24668417-1 2014 Previous studies in rats have demonstrated that microsomal prostaglandin E synthase-1 (mPGES-1) is induced in brain vascular cells that also express inducible cyclooxygenase-2, suggesting that such cells are the source of the increased PGE2 levels that are seen in the brain following peripheral immune stimulation, and that are associated with sickness responses such as fever, anorexia, and stress hormone release. Dinoprostone 236-240 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 159-175 25047516-0 2014 Cyclooxygenase 2 inhibitor celecoxib inhibits glutamate release by attenuating the PGE2/EP2 pathway in rat cerebral cortex endings. Dinoprostone 83-87 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 0-16 25047516-3 2014 In this study, we investigated the effect of celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor that reduces the level of prostaglandin E2 (PGE2), on endogenous glutamate release in rat cerebral cortex nerve terminals (synaptosomes). Dinoprostone 129-145 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 86-91 25047516-3 2014 In this study, we investigated the effect of celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor that reduces the level of prostaglandin E2 (PGE2), on endogenous glutamate release in rat cerebral cortex nerve terminals (synaptosomes). Dinoprostone 147-151 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 68-84 25047516-3 2014 In this study, we investigated the effect of celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor that reduces the level of prostaglandin E2 (PGE2), on endogenous glutamate release in rat cerebral cortex nerve terminals (synaptosomes). Dinoprostone 147-151 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 86-91 24866147-2 2014 Our recent study provided evidence for involvement of cyclooxygenase-2-prostaglandin E2 pathway in Ang II-dependent stimulation of PRR expression in the collecting duct. Dinoprostone 71-87 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 54-70 25324681-13 2014 Meanwhile, COX-2, PGE2, and VEGF expression was inhibited by ERK1/2 inhibitor U0126 and COX-2 inhibitor NS-398. Dinoprostone 18-22 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 88-93 24475143-2 2014 AEGT concentration-dependently inhibited the elevated RNA and protein levels of inducible nitric oxide synthase and cyclooxygenase-2, thereby reducing nitric oxide and prostaglandin E2 levels, respectively. Dinoprostone 168-184 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 116-132 22975359-9 2013 These data suggest that COX-2-derived vasodilator prostanoids, PGI2 and PGE2, produced during endotoxemia increase iNOS protein expression and activity as well as peroxynitrite formation resulting in decreased CYP4A1 protein expression and 20-HETE synthesis. Dinoprostone 72-76 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 24-29 24136226-9 2013 The COX-2-derived 2-AG metabolite, prostaglandin E2 glyceryl ester (PGE2-G), exacerbated neurotoxicity, and this effect was antagonized by the blockade of PGE2-G action with AGN220675. Dinoprostone 68-72 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 4-9 23790320-2 2013 Previously, we observed that lysophosphatidic acid (LPA) increases cyclooxygenase-2 derived - prostaglandin E2 production during implantation in the rat uterus and that it augments the expression of decidualization (IGFBP-1) and vascularization (IL-10) markers. Dinoprostone 94-110 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 67-83 23790320-8 2013 Inducible NOS activity participated in the induction of cyclooxygenase-2/prostaglandin E2 increase stimulated by LPA. Dinoprostone 73-89 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 56-72 23652412-8 2013 Taken together, our results demonstrate that C. obtusa essential oil exerts anti-inflammatory effects by regulating the production of PGE2 and TNFalpha gene expression through the COX-2 pathway. Dinoprostone 134-138 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 180-185 23799821-7 2013 The levels of serum prostaglandin E2 and nitric oxide productions were decreased via suppression of the production of cyclooxygenase-2 and inducible nitric oxide synthase, respectively. Dinoprostone 20-36 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 118-170 22975359-1 2013 We have previously demonstrated that inhibition of vasodilator prostanoids, PGI2 and PGE2, and nitric oxide (NO) synthesis by a selective cyclooxygenase-2 (COX-2) inhibitor, NS-398, restores blood pressure as a result of increased systemic and renal levels of 20-hydroxyeicosatetraenoic acid (20-HETE) in endotoxemic rats. Dinoprostone 85-89 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 138-154 22975359-1 2013 We have previously demonstrated that inhibition of vasodilator prostanoids, PGI2 and PGE2, and nitric oxide (NO) synthesis by a selective cyclooxygenase-2 (COX-2) inhibitor, NS-398, restores blood pressure as a result of increased systemic and renal levels of 20-hydroxyeicosatetraenoic acid (20-HETE) in endotoxemic rats. Dinoprostone 85-89 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 156-161 23404506-4 2013 Real time PCR showed that PGE2 had no effect on expression of CXCL10, TGF-beta1, and IL-11 and exacerbated the rapid up-regulation of mRNAs encoding cyclooxygenase-2, inducible NOS, IL-6, and IL-1beta but blunted the production of mRNAs encoding TNF-alpha, IL-10, CCL3, and CCL4. Dinoprostone 26-30 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 149-165 23818898-12 2013 Moreover, Elk-1, the transcriptional regulator of COX-2 expression, will be a potential target for the prevention of beta -cell dysfunction mediated by PGE2. Dinoprostone 152-156 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 50-55 23818898-2 2013 Prostaglandin E2 (PGE2) production, as a consequence of COX-2 gene induction, has been reported to impair beta -cell function. Dinoprostone 0-16 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 56-61 23261362-5 2013 CHP1002 reduced the production of iNOS-derived nitric oxide (NO) and COX-2-derived prostaglandin E2 (PGE2). Dinoprostone 83-99 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 69-74 23261362-5 2013 CHP1002 reduced the production of iNOS-derived nitric oxide (NO) and COX-2-derived prostaglandin E2 (PGE2). Dinoprostone 101-105 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 69-74 23276664-10 2013 PGE(2) production in response to bradykinin was COX-2-dependent in control animals. Dinoprostone 0-6 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 48-53 23818898-2 2013 Prostaglandin E2 (PGE2) production, as a consequence of COX-2 gene induction, has been reported to impair beta -cell function. Dinoprostone 18-22 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 56-61 22519838-8 2012 Targeting COX2/PGE2/EP signaling in injured nerves through local administration could open a novel therapeutic avenue to treat this debilitating disease. Dinoprostone 15-19 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 10-14 22959208-13 2012 Parecoxib inhibited hippocampal IL-1beta and TNF-alpha expression through downregulation of the COX-2/PGE2 pathway. Dinoprostone 102-106 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 96-101 22713546-7 2012 Leptin also increased the expression of cyclooxygenase-2 (COX-2) and its product, prostaglandin E(2) (PGE(2)), in a dose-dependent manner. Dinoprostone 82-100 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 40-56 22713546-7 2012 Leptin also increased the expression of cyclooxygenase-2 (COX-2) and its product, prostaglandin E(2) (PGE(2)), in a dose-dependent manner. Dinoprostone 82-100 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 58-63 23029388-8 2012 The incubation of LPA with indomethacin or NS-398 reversed the increment in PGE2 production, suggesting that cyclooxygenase-2 was the isoform involved in LPA effect. Dinoprostone 76-80 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 109-125 22089194-4 2012 In LPS-treated microglia, paeonol attenuated the overexpression of inducible nitric oxide synthase and cyclooxygenase 2, leading to the decrease in nitric oxide and prostaglandin E2 production, respectively. Dinoprostone 165-181 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 103-119 22165968-1 2012 UNLABELLED: Accumulating evidence indicates that the cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2) pathway plays a key role in esophageal carcinogenesis. Dinoprostone 78-94 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 53-69 22165968-1 2012 UNLABELLED: Accumulating evidence indicates that the cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2) pathway plays a key role in esophageal carcinogenesis. Dinoprostone 78-94 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 71-76 22165968-1 2012 UNLABELLED: Accumulating evidence indicates that the cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2) pathway plays a key role in esophageal carcinogenesis. Dinoprostone 96-100 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 53-69 22165968-1 2012 UNLABELLED: Accumulating evidence indicates that the cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2) pathway plays a key role in esophageal carcinogenesis. Dinoprostone 96-100 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 71-76 23029388-11 2012 Besides, we also observed that endocannabinoids mediated the stimulatory effect of LPA on cyclooxygenase-2 derived PGE2 production, as the incubation of LPA with AM251 or AM630 completely reversed LPA effect. Dinoprostone 115-119 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 90-106 21371033-6 2011 Perineural injection of a selective cyclooxygenase 2 inhibitor or a selective EP4 receptor antagonist significantly suppressed the up-regulation of IL-6 in DRG, suggesting that injured nerve derived PGE2 contributes to the de novo synthesis of IL-6 in DRG neurons through EP4 receptors. Dinoprostone 199-203 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 36-52 21873648-3 2011 The action of SO(2) on elevating COX-2 ultimately appeared to be dependent on the increased production of arachidonic acid-derived prostaglandins, mainly prostaglandin E(2) (PGE(2)), and functioning of its EP2/4 receptors. Dinoprostone 154-172 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 33-38 21527272-3 2011 Activation of inducible cyclooxygenase-2 (COX-2) in blood-brain-barrier endothelial cells and subsequent release of prostaglandins (e.g., prostaglandin E2, PGE2) may be involved. Dinoprostone 138-154 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 24-40 21527272-3 2011 Activation of inducible cyclooxygenase-2 (COX-2) in blood-brain-barrier endothelial cells and subsequent release of prostaglandins (e.g., prostaglandin E2, PGE2) may be involved. Dinoprostone 138-154 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 42-47 21527272-3 2011 Activation of inducible cyclooxygenase-2 (COX-2) in blood-brain-barrier endothelial cells and subsequent release of prostaglandins (e.g., prostaglandin E2, PGE2) may be involved. Dinoprostone 156-160 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 24-40 21527272-3 2011 Activation of inducible cyclooxygenase-2 (COX-2) in blood-brain-barrier endothelial cells and subsequent release of prostaglandins (e.g., prostaglandin E2, PGE2) may be involved. Dinoprostone 156-160 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 42-47 18786748-3 2010 Injured nerve derived cyclooxygenase 2/prostaglandin E2 (COX2/PGE2) contributes to the genesis of NeP at the early stage in young rats. Dinoprostone 62-66 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 22-55 21328464-1 2011 Proteinase-activated receptor-1 (PAR1), upon activation, exerts prostanoid-dependent gastroprotection, and increases prostaglandin E(2) (PGE(2)) release through cyclooxygenase-2 (COX-2) upregulation in rat gastric mucosal epithelial RGM1 cells. Dinoprostone 137-143 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 161-177 20142564-3 2010 COX-2 generates prostaglandin E(2), which may enter the brain and increase sympathetic nerve activity. Dinoprostone 16-34 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 0-5 20027123-8 2010 Tempol, apocynin [NAD(P)H oxidase inhibitor], SB203580 and NS398 (cyclooxygenase-2 inhibitor) all reduced cerebrospinal fluid prostaglandin E2 and the sympathoexcitatory response to LPS. Dinoprostone 126-142 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 66-82 19352545-13 2009 Our results suggested that DIDS is beneficial in rat model of gastric injury through mechanisms that involve inhibiting inflammatory cell infiltration and lipid peroxidation and up-regulating the COX-2/PGE2 pathway. Dinoprostone 202-206 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 196-201 19679653-6 2009 Our data indicate that in R2C cells the COX-2-derived prostaglandin E2 (PGE2) binds the PGE2 receptor EP4 and activates protein kinase A (PKA) and ultimately CREB. Dinoprostone 54-70 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 40-45 19679653-6 2009 Our data indicate that in R2C cells the COX-2-derived prostaglandin E2 (PGE2) binds the PGE2 receptor EP4 and activates protein kinase A (PKA) and ultimately CREB. Dinoprostone 72-76 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 40-45 19679653-8 2009 The COX-2/PGE2/PKA pathway also seems to be involved in aromatase post-translational activation, an observation that requires further studies. Dinoprostone 10-14 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 4-9 18522674-9 2009 These data indicate that celecoxib reduces intratesticular activity of COX-2 (as indicated by PGE(2) levels) and inhibits IF formation in the testis, but has no appreciable effect on steroidogenesis or spermatogenesis, at least in the short term. Dinoprostone 94-100 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 71-76 19583997-5 2009 Parallel to the decreases in NO and PGE(2) production was a reduction in the expression of inducible NO synthase (iNOS) and cyclooxygenase 2 (COX-2) as measured by mRNA and protein levels. Dinoprostone 36-42 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 124-140 19583997-5 2009 Parallel to the decreases in NO and PGE(2) production was a reduction in the expression of inducible NO synthase (iNOS) and cyclooxygenase 2 (COX-2) as measured by mRNA and protein levels. Dinoprostone 36-42 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 142-147 19826189-11 2009 PGE(2) production in stomach corresponded to the COX-2 expression. Dinoprostone 0-6 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 49-54 19145780-5 2009 Angiotensin II-induced prostaglandin E2 production was reduced by valsartan and the COX-2 inhibitor NS398 (1 micromol/l). Dinoprostone 23-39 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 84-89 18567640-2 2008 In ventricular cardiomyocytes, prostaglandin E(2) (PGE(2)), a major COX-2 product, leads to adaptive growth via Stat3 activation, but whether this transcription factor acts as a signalling molecule in PGE(2)-induced cell survival is unknown. Dinoprostone 31-49 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 68-73 18567640-2 2008 In ventricular cardiomyocytes, prostaglandin E(2) (PGE(2)), a major COX-2 product, leads to adaptive growth via Stat3 activation, but whether this transcription factor acts as a signalling molecule in PGE(2)-induced cell survival is unknown. Dinoprostone 51-57 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 68-73 18183617-0 2008 Retinoic acid enhances prostaglandin E2 production through increased expression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 in rat brain microglia. Dinoprostone 23-39 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 83-99 18782027-3 2008 These compounds inhibit the induction of cyclooxygenase-2 (COX-2), thus inhibiting PGE2 production. Dinoprostone 83-87 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 41-57 18782027-3 2008 These compounds inhibit the induction of cyclooxygenase-2 (COX-2), thus inhibiting PGE2 production. Dinoprostone 83-87 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 59-64 18782027-4 2008 The chemically synthesized chalcone derivative, 2"-hydroxy-4"-methoxychalcone, also inhibits PGE2 production by suppressing COX-2 induction. Dinoprostone 93-97 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 124-129 18782027-5 2008 In contrast, taiwanin C isolated from the roots of Acanthopanax chiisanensis inhibited PGE2 production by direct inhibition of COX-1 and COX-2. Dinoprostone 87-91 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 137-142 18481165-4 2008 Induction of COX-2 expression was accompanied by a significant increase (two- to threefold, p < 0.001) in prostanglandin E2 (PGE2) synthesis in vulnerable regions at symptomatic stages of TD. Dinoprostone 128-132 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 13-18 18481165-6 2008 Administration of nimesulide, a highly specific COX-2 inhibitor, significantly reduced PGE-2 levels in vulnerable regions but, rather than being neuroprotective, precipitated encephalopathy and exacerbated neuronal cell death due to TD. Dinoprostone 87-92 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 48-53 17704286-10 2007 PGE(2) content (but not COX-2 protein) was further increased by the combination of both interventions, suggesting that postconditioning increases the activity of COX-2 induced by late PC. Dinoprostone 0-6 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 162-167 18297109-12 2008 Taken together, these findings demonstrate that 2-AG is oxygenated in vivo by COX-2 producing PGE2-G, which plays a role in pain and immunomodulation. Dinoprostone 94-98 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 78-83 18174279-3 2008 These changes are accompanied by an induced production of IL-1beta and IL-1 receptor type 1 as well as cyclooxygenase-2 and microsomal prostaglandin E synthase-1 in these cells, implying local cytokine-mediated prostaglandin E(2) production in the adrenals, which also displayed prostaglandin E(2) receptors of subtypes 1 and 3 in the cortex and medulla. Dinoprostone 211-229 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 103-119 24459504-1 2007 This study aimed to examine whether the expression of major prostaglandin E2 (PGE2) synthesis enzyme, cyclooxygenase-2 (COX-2), is changed in the kidneys of the rats with lithium-induced nephrogenic diabetes insipidus (Li-NDI). Dinoprostone 60-76 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 102-118 24459504-1 2007 This study aimed to examine whether the expression of major prostaglandin E2 (PGE2) synthesis enzyme, cyclooxygenase-2 (COX-2), is changed in the kidneys of the rats with lithium-induced nephrogenic diabetes insipidus (Li-NDI). Dinoprostone 60-76 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 120-125 24459504-1 2007 This study aimed to examine whether the expression of major prostaglandin E2 (PGE2) synthesis enzyme, cyclooxygenase-2 (COX-2), is changed in the kidneys of the rats with lithium-induced nephrogenic diabetes insipidus (Li-NDI). Dinoprostone 78-82 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 102-118 24459504-1 2007 This study aimed to examine whether the expression of major prostaglandin E2 (PGE2) synthesis enzyme, cyclooxygenase-2 (COX-2), is changed in the kidneys of the rats with lithium-induced nephrogenic diabetes insipidus (Li-NDI). Dinoprostone 78-82 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 120-125 17868147-2 2007 Prostaglandin E(2) (PGE(2)) is one of the key products of COX-2 activity and PGE(2) production is increased in PD. Dinoprostone 0-18 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 58-63 17868147-2 2007 Prostaglandin E(2) (PGE(2)) is one of the key products of COX-2 activity and PGE(2) production is increased in PD. Dinoprostone 20-26 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 58-63 17943254-2 2007 In addition, prostaglandin E2 (PGE2), derived from cyclooxygenase-2, stimulates VEGF release in gastric fibroblasts. Dinoprostone 13-29 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 51-67 17943254-2 2007 In addition, prostaglandin E2 (PGE2), derived from cyclooxygenase-2, stimulates VEGF release in gastric fibroblasts. Dinoprostone 31-35 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 51-67 16754782-6 2006 It is suggested that TNF-alpha-induced increases of PKA expression and cAMP levels are mediated by releasing PGE2 and PGI2, the activation products of COX-2. Dinoprostone 109-113 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 151-156 17537981-6 2007 Kidney disease was associated with elevated renal COX-1 and COX-2 enzyme activities, and NS-398 blunted the increase in COX-2 enzyme activity (as indicated by 21 and 28% lower renal thromboxane B2 and PGE2 levels, respectively). Dinoprostone 201-205 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 120-125 17505916-2 2007 Prostaglandin E2 (PGE2) production, as a consequence of COX-2 gene induction, has been reported to impair beta-cell function. Dinoprostone 0-16 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 56-61 17505916-2 2007 Prostaglandin E2 (PGE2) production, as a consequence of COX-2 gene induction, has been reported to impair beta-cell function. Dinoprostone 18-22 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 56-61 17505916-10 2007 Moreover, these transcriptional regulators of COX-2 expression will be potential targets for the prevention of beta-cell damage mediated by PGE2. Dinoprostone 140-144 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 46-51 17234396-5 2007 Supplementation with FO resulted in significantly lower tumor weight, greater tumor cell apoptosis, lower ex vivo tumor cell proliferation, a higher tumor content of lipid peroxides, lower expression of cyclooxygenase-2 (COX-2) in tumor tissue and a lower plasma concentration of prostaglandin E2 than observed in rats fed regular chow or supplemented with coconut oil. Dinoprostone 280-296 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 221-226 17331331-4 2006 Western blot and reverse transcriptase-polymerase chain reaction analyses have shown that the inhibition of PGE(2) production by these synthetic derivatives was mediated at least in part by COX-2 inhibition, but not by COX-2 down-regulation. Dinoprostone 108-114 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 190-195 16809483-7 2006 Interestingly, nuclear signal transducer and activator of transcription (STAT)3-positive cells colocalized with COX-2-IR, signifying that IL-6-activated cells are directly involved in PGE2 production. Dinoprostone 184-188 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 112-117 17251525-0 2007 Constitutive expression of prostaglandin-endoperoxide synthase 2 by somatic and spermatogenic cells is responsible for prostaglandin E2 production in the adult rat testis. Dinoprostone 119-135 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 27-64 16616432-6 2006 Indomethacin, the prostaglandin synthesis inhibitor, efficiently blocked lipopolysaccharide-induced enhancement of spike-wave discharge genesis suggesting that the spike-wave discharge facilitating effect of lipopolysaccharides involves induction of cyclooxygenase 2 and subsequent synthesis and actions of prostaglandin E2. Dinoprostone 307-323 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 250-266 16322109-10 2006 Similarly, prostaglandin E(2) levels were markedly lower, indicating strong inhibition of COX-2 activity (p<0.003). Dinoprostone 11-29 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 90-95 16580130-0 2006 The long-term exposure of rat cultured dorsal root ganglion cells to bradykinin induced the release of prostaglandin E2 by the activation of cyclooxygenase-2. Dinoprostone 103-119 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 141-157 16427196-0 2006 Peripheral inflammation modifies the effect of intrathecal IL-1beta on spinal PGE2 production mainly through cyclooxygenase-2 activity. Dinoprostone 78-82 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 109-125 16309709-4 2006 We therefore studied whether the COX-2 reaction product PGE2 affects glutamate receptor-mediated cell death in cultured rat cortical cells. Dinoprostone 56-60 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 33-38 16680021-13 2006 LPS treatment also stimulated the levels of cyclooxygenase-2 and the production of downstream metabolites, specifically PGE2 and 15deoxyDelta12-14PGJ2 (15dPGJ2). Dinoprostone 120-124 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 44-60 16210398-8 2006 COX-2 inhibitors significantly inhibited the increase in PGE2 synthesis in oesophageal lesions on both days 3 and 21. Dinoprostone 57-61 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 0-5 16210398-11 2006 CONCLUSION: PGE2 derived from COX-2 and mPGES-1 plays a significant role in the pathogenesis of chronic acid reflux oesophagitis, and possibly in basal hyperplasia and persistent inflammatory cell infiltration. Dinoprostone 12-16 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 30-35 15979590-7 2005 Hippocampal PGE2 levels were increased at 24 h following seizures, and treatment with the selective COX-2 inhibitor SC58125, 3 mg/kg p.o., attenuated the increase in PGE2 concentration. Dinoprostone 166-170 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 100-105 16912428-4 2006 As the stimulated synthesis of PGE2 originates from the preferential coupling of inducible enzymes, cyclooxygenase-2 (COX-2) and membrane PGE synthase-1 (mPGES-1), we investigated the potency of 15d-PGJ2 to regulate prostaglandins synthesis in rat chondrocytes stimulated with interleukin-1beta (IL-1beta). Dinoprostone 31-35 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 100-116 16912428-4 2006 As the stimulated synthesis of PGE2 originates from the preferential coupling of inducible enzymes, cyclooxygenase-2 (COX-2) and membrane PGE synthase-1 (mPGES-1), we investigated the potency of 15d-PGJ2 to regulate prostaglandins synthesis in rat chondrocytes stimulated with interleukin-1beta (IL-1beta). Dinoprostone 31-35 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 118-123 16006544-10 2005 Production of PGE2, a principal COX-2-derived prostaglandin end product, was also greatest in cerebral vessels isolated from ORXT rats. Dinoprostone 14-18 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 32-37 16300746-10 2005 Our work supports a role for PAR2 as a defence mechanism aimed to preserve bronchial functionality under systemic inflammatory conditions; both COX-2-derived PGE2 and CGRP are involved in this effect. Dinoprostone 158-162 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 144-149 16023763-9 2005 CONCLUSIONS: This is the first demonstration that a specific COX-2 inhibitor, celecoxib, possesses striking chemopreventive activity, inhibiting preneoplastic lesions during hepatocarcinogenesis in vivo, suggesting that celecoxib effects are mediated by PGE2-independent mechanisms. Dinoprostone 254-258 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 61-66 16000148-8 2005 These results suggest that the activation of microglia contributes to PGE2 production through the concerted de novo synthesis of mPGES-1 and COX-2 at sites of inflammation of the brain parenchyma. Dinoprostone 70-74 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 141-146 15525691-8 2005 Furthermore, the cell death was prevented by PGE2 treatment, suggesting that 2,2",4,6,6"-PeCB-induced apoptosis is restricted by prostaglandin upregulation by COX-2. Dinoprostone 45-49 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 159-164 15964567-4 2005 In the present study, we determined if prostaglandin E(2) (PGE(2)) is responsible for this cyclooxygenase-2-mediated effect. Dinoprostone 39-57 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 91-107 15964567-4 2005 In the present study, we determined if prostaglandin E(2) (PGE(2)) is responsible for this cyclooxygenase-2-mediated effect. Dinoprostone 59-65 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 91-107 15652766-9 2005 Together, this study confirms the role played by COX-2 enzyme in the resolution of acute and chronic gastric inflammatory process, PGE(2) being the principal product. Dinoprostone 131-137 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 49-54 15591708-5 2005 In addition, the inhibitory effect of NIM on endotoxin-induced elevation in plasma and hypothalamic levels of PGE2 was noteworthy, and this may suggest that the large amounts of PGE2 observed during endotoxemia are mainly produced via COX-2. Dinoprostone 178-182 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 235-240 15670336-10 2005 By contrast, nicotine enhances the expression of cyclooxygenase-2 and the synthesis of one of its major products, prostaglandin E2. Dinoprostone 114-130 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 49-65 15591708-5 2005 In addition, the inhibitory effect of NIM on endotoxin-induced elevation in plasma and hypothalamic levels of PGE2 was noteworthy, and this may suggest that the large amounts of PGE2 observed during endotoxemia are mainly produced via COX-2. Dinoprostone 110-114 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 235-240 16032457-13 2005 COX-2 inhibitor attenuated the impairment of oxygenation 8 h after instillation but not after 1 h. Intratracheal HCl caused an increase in PGE2 concentration. Dinoprostone 139-143 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 0-5 16032457-14 2005 COX-2 inhibitor attenuated an increase in PGE2 concentration 8 h after instillation but not after 1 h. The results show that COX-2 inhibitor attenuates the oxygenation impairment and the increase in alveolar PGE2 concentration during the inflammatory phase of acid aspiration-induced lung injury in rats. Dinoprostone 42-46 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 0-5 16032457-14 2005 COX-2 inhibitor attenuated an increase in PGE2 concentration 8 h after instillation but not after 1 h. The results show that COX-2 inhibitor attenuates the oxygenation impairment and the increase in alveolar PGE2 concentration during the inflammatory phase of acid aspiration-induced lung injury in rats. Dinoprostone 42-46 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 125-130 16032457-14 2005 COX-2 inhibitor attenuated an increase in PGE2 concentration 8 h after instillation but not after 1 h. The results show that COX-2 inhibitor attenuates the oxygenation impairment and the increase in alveolar PGE2 concentration during the inflammatory phase of acid aspiration-induced lung injury in rats. Dinoprostone 208-212 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 0-5 16032457-14 2005 COX-2 inhibitor attenuated an increase in PGE2 concentration 8 h after instillation but not after 1 h. The results show that COX-2 inhibitor attenuates the oxygenation impairment and the increase in alveolar PGE2 concentration during the inflammatory phase of acid aspiration-induced lung injury in rats. Dinoprostone 208-212 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 125-130 15830643-1 2005 BACKGROUND: The present study was planned to evaluate the individual and combined effects of selective cyclooxygenase-2 (COX-2) inhibitor, celecoxib, and omega-3 fatty acid on the gingival tissue levels of prostaglandin E2 (PGE2), prostaglandin F2alpha (PGF2alpha), leukotriene B4 (LTB4), and platelet activating factor (PAF) in endotoxin-induced periodontitis in rats. Dinoprostone 206-222 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 103-119 15501994-4 2005 A recent study demonstrated cyclooxygenase-2-dependent, prostaglandin E(2) (PGE(2))-mediated regulation of mdr1b expression in primary rat hepatocyte cultures. Dinoprostone 56-74 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 28-44 15501994-4 2005 A recent study demonstrated cyclooxygenase-2-dependent, prostaglandin E(2) (PGE(2))-mediated regulation of mdr1b expression in primary rat hepatocyte cultures. Dinoprostone 76-82 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 28-44 15113870-9 2004 CONCLUSIONS: These results suggest that COX-2 suppresses the expression of alpha(v) integrins by an increased production of PGE(2) activating its EP(3) receptor in glomerulonephritis. Dinoprostone 124-130 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 40-45 15575215-6 2004 RESULT: The data showed that Sin down-regulated the expression of COX-2 mRNA and protein, and reduced the production of PGE2 in the LPS-stimulated PC-12 cells which correlated with Sin"s concentrations positively. Dinoprostone 120-124 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 66-71 15156148-3 2004 Here we report that increases in prostaglandin-E(2) (PGE(2)), resulting from changes in cyclooxygenase-2 (COX-2) regulation induced by perinatal exposure to estradiol, are necessary and sufficient to organize the crucial neural substrate that mediates male sexual behavior. Dinoprostone 33-51 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 88-104 15156148-3 2004 Here we report that increases in prostaglandin-E(2) (PGE(2)), resulting from changes in cyclooxygenase-2 (COX-2) regulation induced by perinatal exposure to estradiol, are necessary and sufficient to organize the crucial neural substrate that mediates male sexual behavior. Dinoprostone 33-51 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 106-111 15156148-3 2004 Here we report that increases in prostaglandin-E(2) (PGE(2)), resulting from changes in cyclooxygenase-2 (COX-2) regulation induced by perinatal exposure to estradiol, are necessary and sufficient to organize the crucial neural substrate that mediates male sexual behavior. Dinoprostone 53-59 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 88-104 15156148-3 2004 Here we report that increases in prostaglandin-E(2) (PGE(2)), resulting from changes in cyclooxygenase-2 (COX-2) regulation induced by perinatal exposure to estradiol, are necessary and sufficient to organize the crucial neural substrate that mediates male sexual behavior. Dinoprostone 53-59 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 106-111 15292051-1 2004 Induction of cyclooxygenase-2 (COX-2) in the renal pelvic wall increases prostaglandin E(2) (PGE(2)) leading to stimulation of cAMP production, which results in substance P (SP) release and activation of renal mechanosensory nerves. Dinoprostone 73-91 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 13-29 15292051-1 2004 Induction of cyclooxygenase-2 (COX-2) in the renal pelvic wall increases prostaglandin E(2) (PGE(2)) leading to stimulation of cAMP production, which results in substance P (SP) release and activation of renal mechanosensory nerves. Dinoprostone 73-91 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 31-36 15364005-0 2004 Inhibition of cyclooxygenase-2, but not cyclooxygenase-1, reduces prostaglandin E2 secretion from diabetic rat retinas. Dinoprostone 66-82 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 14-30 15364005-3 2004 In this ex vivo study, we tested whether cyclooxygenase-1 or cyclooxygenase-2 is responsible for diabetes-induced secretion of prostaglandin E2 from isolated rat retinas. Dinoprostone 127-143 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 61-77 15364005-5 2004 These results suggests that the enzymatic activity of cyclooxygenase-2, but not cyclooxygenase-1, results in prostaglandin E2 secretion under diabetic conditions. Dinoprostone 109-125 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 54-70 15249543-9 2004 Prostaglandin E2 production increased when these cells were challenged with bradykinin for 4 hours, indicating that COX-2 was enzymatically active. Dinoprostone 0-16 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 116-121 15044444-10 2004 The data also indicate that the up-regulation of mPGES-1 contributes to COX-2-mediated PGE(2) production in the CNS during peripheral inflammation. Dinoprostone 87-93 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 72-77 15273422-8 2004 Regardless of these increases, the intrarenal COX-2 inhibition caused comparable decreases in glomerular filtration rate, in absolute and fractional sodium excretion, as well as in urinary PGE2 excretion in TGR and HanSD rats kept on the LS diet. Dinoprostone 189-193 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 46-51 14751415-14 2004 Administration of HGF without induction of acute pancreatitis increased pancreatic prostaglandin E(2) generation and plasma interleukin-10, and this effect was abolished by the cyclooxygenase-2 inhibitor, rofecoxib. Dinoprostone 83-101 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 177-193 15057907-3 2004 Celecoxib and another COX-2 inhibitor, rofecoxib, at 5 microM were almost equally effective in inhibiting prostaglandin E(2) (PGE(2)) production by these cells, but at this low concentration, neither inhibitor suppressed growth or induced apoptosis. Dinoprostone 106-124 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 22-27 15057907-3 2004 Celecoxib and another COX-2 inhibitor, rofecoxib, at 5 microM were almost equally effective in inhibiting prostaglandin E(2) (PGE(2)) production by these cells, but at this low concentration, neither inhibitor suppressed growth or induced apoptosis. Dinoprostone 126-132 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 22-27 15090964-0 2004 Burn injury enhances brain prostaglandin E2 production through induction of cyclooxygenase-2 and microsomal prostaglandin E synthase in cerebral vascular endothelial cells in rats. Dinoprostone 27-43 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 76-92 15090964-7 2004 MEASUREMENTS AND MAIN RESULTS: The prostaglandin E2 concentration in the cerebrospinal fluid was significantly elevated in the injured rats, and this elevation was suppressed by a cyclooxygenase-2-specific inhibitor, NS398. Dinoprostone 35-51 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 180-196 14643689-0 2004 The cyclooxygenase-2 product prostaglandin E2 modulates cardiac contractile function in adult rat ventricular cardiomyocytes. Dinoprostone 29-45 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 4-20 14643689-1 2004 Prostaglandin E(2) (PGE(2)), a product of the cyclooxygenase-2 pathway, has been shown to increase cardiac output and modulate cardiac contractile function. Dinoprostone 0-18 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 46-62 14555660-3 2003 The inducible prostaglandin E2 (PGE2) biosynthetic enzymes cyclooxygenase-2 (COX-2) and mPGES-1 are up-regulated in many cancers. Dinoprostone 14-30 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 59-75 14555660-3 2003 The inducible prostaglandin E2 (PGE2) biosynthetic enzymes cyclooxygenase-2 (COX-2) and mPGES-1 are up-regulated in many cancers. Dinoprostone 14-30 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 77-82 14555660-3 2003 The inducible prostaglandin E2 (PGE2) biosynthetic enzymes cyclooxygenase-2 (COX-2) and mPGES-1 are up-regulated in many cancers. Dinoprostone 32-36 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 59-75 14555660-3 2003 The inducible prostaglandin E2 (PGE2) biosynthetic enzymes cyclooxygenase-2 (COX-2) and mPGES-1 are up-regulated in many cancers. Dinoprostone 32-36 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 77-82 14561156-3 2003 In the pharmacological experiments, prostaglandin G/H synthase (PGHS)-2-dependent PGE(2) production was inhibited by 10 muM of AF. Dinoprostone 82-88 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 36-71