PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7910781-13 1993 The addition of an exogenous source of recombinant IL-2 (rIL-2) to T cells stimulated in the presence of DEX and PGE2 completely reversed the synergistic antiproliferative effect of these two compounds. Dinoprostone 113-117 interleukin 2 Rattus norvegicus 57-62 12353920-1 2002 PGE2 is known to suppress T cell proliferation and IL-2 production in many inflammatory conditions. Dinoprostone 0-4 interleukin 2 Rattus norvegicus 51-55 12353920-7 2002 The treatments of burn-injured animals with PGE2 synthesis blocker indomethacin prevented both the decrease in NFAT and AP-1 binding to IL-2 sequences. Dinoprostone 44-48 interleukin 2 Rattus norvegicus 136-140 12353920-9 2002 These results suggested that the suppression of T cell IL-2 production could result from PGE2-mediated alterations in the T cell signaling molecule p59fyn and NFAT/AP-1. Dinoprostone 89-93 interleukin 2 Rattus norvegicus 55-59 9551931-1 1998 Prostaglandin E2 (PGE2) has been implicated in the suppression of T cell IL-2 production and proliferation during burn and sepsis. Dinoprostone 0-16 interleukin 2 Rattus norvegicus 73-77 9551931-1 1998 Prostaglandin E2 (PGE2) has been implicated in the suppression of T cell IL-2 production and proliferation during burn and sepsis. Dinoprostone 18-22 interleukin 2 Rattus norvegicus 73-77 8649180-4 1996 This effect correlated with ability of IL-2 to enhance PGE2 production by 3T3 fibroblasts. Dinoprostone 55-59 interleukin 2 Rattus norvegicus 39-43 10232394-0 1999 Prostaglandin E2 down-regulation of T cell IL-2 production is independent of IL-10 during gram-negative sepsis. Dinoprostone 0-16 interleukin 2 Rattus norvegicus 43-47 10232394-1 1999 The present study ascertained the role of PGE2 in sepsis associated modulation of IL-2 and IL-10 production by T cells. Dinoprostone 42-46 interleukin 2 Rattus norvegicus 82-86 10232394-9 1999 These data suggest that although PGE2 released during sepsis can cause T cell IL-2 down-regulation, it may not mediate the T cell IL-10 upregulation. Dinoprostone 33-37 interleukin 2 Rattus norvegicus 78-82 7531117-2 1995 In support, this study shows that PGE2 inhibited myelin basic protein (MBP)-specific responses of proliferation and IL-2 production by continuously propagated lines of T-helper cells. Dinoprostone 34-38 interleukin 2 Rattus norvegicus 116-120 7531117-5 1995 PGE2 did not block other measures of MBP-dependent activation, including induction of postactivation refractoriness in IL-2 production pathways, activation-dependent decreases in MBP reactivity, and activation-dependent increases in PGE2 sensitivity. Dinoprostone 0-4 interleukin 2 Rattus norvegicus 119-123 7531117-7 1995 PGE2-mediated anergy was manifest as an intrinsic deficit rather than an acquired suppressive activity and was associated with reduced mitogenic responsiveness and a block in IL-2 production pathways. Dinoprostone 0-4 interleukin 2 Rattus norvegicus 175-179 8198981-4 1994 During rIL-2 infusion, responders developed high circulating levels of IL-6 and had low constant levels of prostaglandin E2 (PGE2). Dinoprostone 107-123 interleukin 2 Rattus norvegicus 7-12 8198981-4 1994 During rIL-2 infusion, responders developed high circulating levels of IL-6 and had low constant levels of prostaglandin E2 (PGE2). Dinoprostone 125-129 interleukin 2 Rattus norvegicus 7-12 1477603-5 1992 Further studies on the inhibitory mechanism clarified that PGE2 from the contaminated macrophages suppressed the formation and release of interleukin-2 (IL-2), whereas the expression of IL-2 receptors on thymic lymphocyte with Con A stimulation was not affected. Dinoprostone 59-63 interleukin 2 Rattus norvegicus 138-151 1477603-5 1992 Further studies on the inhibitory mechanism clarified that PGE2 from the contaminated macrophages suppressed the formation and release of interleukin-2 (IL-2), whereas the expression of IL-2 receptors on thymic lymphocyte with Con A stimulation was not affected. Dinoprostone 59-63 interleukin 2 Rattus norvegicus 153-157 1846109-7 1991 Corticosterone production stimulated by IL-1 alpha or IL-2 was accompanied by intracellular and extracellular cAMP and PGE2 accumulation. Dinoprostone 119-123 interleukin 2 Rattus norvegicus 54-58 1846109-11 1991 Submaximal doses of IL-1 alpha and IL-2 synergistically stimulated PGE2 production, but did not have even additional effects on cAMP and corticosterone levels. Dinoprostone 67-71 interleukin 2 Rattus norvegicus 35-39 2470519-5 1989 Conversely, PGE2 inhibited both GPMBP- and IL-2-stimulated proliferation of MBP-sensitized lymphocytes. Dinoprostone 12-16 interleukin 2 Rattus norvegicus 43-47 2785152-2 1989 We examined the effect of recombinant (rIL-2) on the in vitro production of IL-1 beta and PGE2 by unstimulated and LPS-activated human blood mononuclear cells (PBMC). Dinoprostone 90-94 interleukin 2 Rattus norvegicus 39-44