PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31883408-2	2020	The aim of this study was to investigate the role of farnesoid X receptor (FXR) in 1-deoxysphingolipid de novo synthesis and degradation.	amphetaminil	83-102	nuclear receptor subfamily 1, group H, member 4	Mus musculus	53-73	
31883408-2	2020	The aim of this study was to investigate the role of farnesoid X receptor (FXR) in 1-deoxysphingolipid de novo synthesis and degradation.	amphetaminil	83-102	nuclear receptor subfamily 1, group H, member 4	Mus musculus	75-78	
31883408-8	2020	FXR activation by OCA protected the liver against oxidative stress, apoptosis, and reduced 1-deoxysphingolipid levels, both in a HFD-induced mouse model of obesity and in 1-deoxysphinganine-treated mice.	amphetaminil	91-110	nuclear receptor subfamily 1, group H, member 4	Mus musculus	0-3	
31883408-9	2020	In vitro, FXR activation lowered intracellular 1-deoxysphingolipid levels by inducing Cyp4f -mediated degradation, but not by inhibiting de novo synthesis, thereby protecting hepatocytes against doxSA-induced cytotoxicity, mitochondrial damage, and apoptosis.	amphetaminil	47-66	nuclear receptor subfamily 1, group H, member 4	Mus musculus	10-13	
31883408-11	2020	Treatment with the Cyp4f pan-inhibitor HET0016 or FXR knockdown fully abolished the protective effect of OCA, indicating that OCA-mediated 1-deoxysphingolipid degradation is FXR- and Cyp4f-dependent.	amphetaminil	139-158	nuclear receptor subfamily 1, group H, member 4	Mus musculus	50-53	
31883408-11	2020	Treatment with the Cyp4f pan-inhibitor HET0016 or FXR knockdown fully abolished the protective effect of OCA, indicating that OCA-mediated 1-deoxysphingolipid degradation is FXR- and Cyp4f-dependent.	amphetaminil	139-158	nuclear receptor subfamily 1, group H, member 4	Mus musculus	174-177	
31883408-12	2020	CONCLUSIONS: Our study identifies FXR-Cyp4f as a novel regulatory pathway for 1-deoxysphingolipid metabolism.	amphetaminil	78-97	nuclear receptor subfamily 1, group H, member 4	Mus musculus	34-37