PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9591925-2 1998 METHODS: Ten patients scheduled for cardiac surgery presented with pulmonary hypertension (mean pulmonary artery pressure greater than 30 mmHg) after protamine injection and were treated by infusion of 0.02 microg x kg(-1) x min(-1) prostaglandin E1. Alprostadil 233-249 CD59 molecule (CD59 blood group) Homo sapiens 225-231 16167789-4 2005 In the latter group, PGE1 was administered intravenously at a rate of 0.05 microg x kg(-1) x min(-1) during surgery. Alprostadil 21-25 CD59 molecule (CD59 blood group) Homo sapiens 93-99 11263368-4 1998 In the experimental group, PGE1(0.5 microgram/kg.min-1) was injected intravenously into the donor before the operation, and added (1 mg/L) to the flush and preservation fluid, while PGE1 was replaced by normal saline in the control group. Alprostadil 27-31 CD59 molecule (CD59 blood group) Homo sapiens 49-54 7588672-3 1995 One group received 0.05 micrograms kg-1 min-1 of PGE1, the second group received 0.1 microgram kg-1 min-1 of PGE1 just after the induction of anaesthesia, and the third group received no PGE1 during anaesthesia (control). Alprostadil 109-113 CD59 molecule (CD59 blood group) Homo sapiens 100-105 9185458-3 1997 In PGE1 group, PGE1 was infused throughout surgery at a rate of 0.02 microgram kg-1 min-1. Alprostadil 3-7 CD59 molecule (CD59 blood group) Homo sapiens 84-89 9185458-3 1997 In PGE1 group, PGE1 was infused throughout surgery at a rate of 0.02 microgram kg-1 min-1. Alprostadil 15-19 CD59 molecule (CD59 blood group) Homo sapiens 84-89 9185466-2 1997 As the vasodilator, we used PGE1 at the dose of 0.02-0.05 microgram.kg-1.min-1. Alprostadil 28-32 CD59 molecule (CD59 blood group) Homo sapiens 73-78 8847783-5 1996 Fourteen patients who received PG 0.02 micrograms.kg-1.min-1 were defined as a PG group. Alprostadil 79-81 CD59 molecule (CD59 blood group) Homo sapiens 55-60 9043849-9 1997 In an initial dose-ranging test, prostaglandin E1 was uptitrated to side effect limit (29 +/- 1 ng.kg-1.min-1). Alprostadil 33-49 CD59 molecule (CD59 blood group) Homo sapiens 104-109 9043849-13 1997 After 4 weeks in six patients in group A and in 13 patients in group B, when prostaglandin E1 had been reduced from 15 +/- 2 ng.kg-1.min-1 to 8 +/- 1 ng.kg-1 min-1 increases in cardiac index and decreases in systemic vascular resistance were sustained, and a permanent decrease in pulmonary vascular resistance index was observed in group B. Alprostadil 77-93 CD59 molecule (CD59 blood group) Homo sapiens 133-138 9043849-13 1997 After 4 weeks in six patients in group A and in 13 patients in group B, when prostaglandin E1 had been reduced from 15 +/- 2 ng.kg-1.min-1 to 8 +/- 1 ng.kg-1 min-1 increases in cardiac index and decreases in systemic vascular resistance were sustained, and a permanent decrease in pulmonary vascular resistance index was observed in group B. Alprostadil 77-93 CD59 molecule (CD59 blood group) Homo sapiens 158-163 7588672-3 1995 One group received 0.05 micrograms kg-1 min-1 of PGE1, the second group received 0.1 microgram kg-1 min-1 of PGE1 just after the induction of anaesthesia, and the third group received no PGE1 during anaesthesia (control). Alprostadil 109-113 CD59 molecule (CD59 blood group) Homo sapiens 100-105 7588672-8 1995 This result suggests that 0.05 micrograms kg-1 min-1 of PGE1 may be superior to 0.1 microgram kg-1 min-1 of PGE1 for maintaining central and peripheral temperatures during surgery and general anaesthesia. Alprostadil 56-60 CD59 molecule (CD59 blood group) Homo sapiens 47-52 8415813-2 1993 Haemodynamic and renal functional response to low dose PGE1 (0.02 microgram kg-1 min-1) (group A) or saline (group B) infusion via peripheral vein during CPB was evaluated in 20 patients who underwent cardiac surgery. Alprostadil 55-59 CD59 molecule (CD59 blood group) Homo sapiens 81-86 8164326-2 1994 The author measured blood gases, blood sugar, L/P, ATP, the deformability of red blood cell, 2,3-DPG, and P50 in patients who had intravenous administration of low dose of PGE1 (0.05-0.1 microgram.kg-1 x min-1, n = 10), NIC (1.0-5.0 micrograms.kg-1 x min-1, n = 10) and TNG (0.5-1.0 microgram.kg-1 x min-1, n = 10). Alprostadil 172-176 CD59 molecule (CD59 blood group) Homo sapiens 204-209 8164326-2 1994 The author measured blood gases, blood sugar, L/P, ATP, the deformability of red blood cell, 2,3-DPG, and P50 in patients who had intravenous administration of low dose of PGE1 (0.05-0.1 microgram.kg-1 x min-1, n = 10), NIC (1.0-5.0 micrograms.kg-1 x min-1, n = 10) and TNG (0.5-1.0 microgram.kg-1 x min-1, n = 10). Alprostadil 172-176 CD59 molecule (CD59 blood group) Homo sapiens 251-256 8164326-2 1994 The author measured blood gases, blood sugar, L/P, ATP, the deformability of red blood cell, 2,3-DPG, and P50 in patients who had intravenous administration of low dose of PGE1 (0.05-0.1 microgram.kg-1 x min-1, n = 10), NIC (1.0-5.0 micrograms.kg-1 x min-1, n = 10) and TNG (0.5-1.0 microgram.kg-1 x min-1, n = 10). Alprostadil 172-176 CD59 molecule (CD59 blood group) Homo sapiens 251-256 8164327-3 1994 PGE1 group was infused intravenously with PGE1 at a rate of 30 ng.kg-1 x min-1 during surgery and at a rate of 10-30 ng.kg-1 x min-1 after surgery. Alprostadil 0-4 CD59 molecule (CD59 blood group) Homo sapiens 73-78 8164327-3 1994 PGE1 group was infused intravenously with PGE1 at a rate of 30 ng.kg-1 x min-1 during surgery and at a rate of 10-30 ng.kg-1 x min-1 after surgery. Alprostadil 0-4 CD59 molecule (CD59 blood group) Homo sapiens 127-132 8164327-3 1994 PGE1 group was infused intravenously with PGE1 at a rate of 30 ng.kg-1 x min-1 during surgery and at a rate of 10-30 ng.kg-1 x min-1 after surgery. Alprostadil 42-46 CD59 molecule (CD59 blood group) Homo sapiens 73-78 8164328-4 1994 Seven patients (PGE1 group) were given continuous infusion of PGE1 at a rate of 50 ng.kg-1 x min-1 after first measurement (baseline). Alprostadil 16-20 CD59 molecule (CD59 blood group) Homo sapiens 93-98 8164328-4 1994 Seven patients (PGE1 group) were given continuous infusion of PGE1 at a rate of 50 ng.kg-1 x min-1 after first measurement (baseline). Alprostadil 62-66 CD59 molecule (CD59 blood group) Homo sapiens 93-98 7699829-2 1995 In control group, infusion of PGE1 at a rate of 20 ng.kg-1.min-1 decreased pulmonary arterial pressure significantly, but not in elderly patients even at a rate of 50 ng.kg-1.min-1. Alprostadil 30-34 CD59 molecule (CD59 blood group) Homo sapiens 59-64 7699829-2 1995 In control group, infusion of PGE1 at a rate of 20 ng.kg-1.min-1 decreased pulmonary arterial pressure significantly, but not in elderly patients even at a rate of 50 ng.kg-1.min-1. Alprostadil 30-34 CD59 molecule (CD59 blood group) Homo sapiens 175-180 8254878-4 1993 Continuous infusion of prostaglandin E1 0.05-0.10 microgram.kg-1 x min-1 and bolus infusion of 7.0% NaHCO3 during the operation were useful in controlling blood pressure, improving hyperkalemia and maintaining renal function. Alprostadil 23-39 CD59 molecule (CD59 blood group) Homo sapiens 67-72 8112140-2 1993 In group 1, 10 cases were treated with PGE1 at a dosage of 20ng/kg.min-1, It was found that pulmonary arterial pressure (mPAP) and pulmonary vascular resistance (PVR) decreased by 23.3% and 38.7% respectively, CI and DO2 increased significantly; blood viscosity decreased significantly, but mean arterial pressure (MAP) and PaO2 were not affected. Alprostadil 39-43 CD59 molecule (CD59 blood group) Homo sapiens 67-72 8112140-4 1993 In group 2, 8 of the 10 cases were treated with PGE1 at a dosage of 40ng/kg.min-1. Alprostadil 48-52 CD59 molecule (CD59 blood group) Homo sapiens 76-81 8112140-7 1993 These results showed that PGE1 at a dosage of 20ng/kg.min-1 is effective, well-tolerated and yields less side effects. Alprostadil 26-30 CD59 molecule (CD59 blood group) Homo sapiens 54-59 6541974-4 1984 In eight subjects given PGE1 (0.2 microgram X kg-1 X min-1, iv), blood pressure fell, whereas both heart rate and cardiac output rose. Alprostadil 24-28 CD59 molecule (CD59 blood group) Homo sapiens 53-58 2049253-7 1991 Seven randomized doses of PGE1 ranging from 0.01 to 1.3 micrograms kg-1 min-1 (2.83 to 364 pmol kg-1 min-1) were infused in an isotonic control saline solution. Alprostadil 26-30 CD59 molecule (CD59 blood group) Homo sapiens 72-77 2049253-10 1991 Whatever the dose, PGE1 induced secretion of water, Na+, K+ and Cl- which was dose-dependent and saturable, with a mean Km of congruent to 6-8 pmol kg-1 min-1, suggesting that at the pharmacological doses used, enterocytes have a saturable membrane site similar to a single class of receptor for PGE1. Alprostadil 19-23 CD59 molecule (CD59 blood group) Homo sapiens 153-158 8437352-4 1993 PGE1 increased urine output and creatinine clearance (Ccr) during hypotension in dose dependent manner, and the changes were statistically significant compared with control at the dose of 0.02 micrograms.kg-1 x min-1 (gamma). Alprostadil 0-4 CD59 molecule (CD59 blood group) Homo sapiens 211-216 1547050-3 1992 Arterial hypotension was induced with PGE1 0.1 micrograms kg-1 min-1 initially and adjusted to maintain mean arterial pressure at about 70 mm Hg. Alprostadil 38-42 CD59 molecule (CD59 blood group) Homo sapiens 63-68 1874208-8 1991 Therefore, the infusion rate of PGE1 during CPB should be 30 ng kg-1 min-1 or less in order to avoid severe hypotension. Alprostadil 32-36 CD59 molecule (CD59 blood group) Homo sapiens 69-74 6546186-9 1983 Groups V and VIII received 3-hour intra-arterial infusions of PGE1 (10(-1) micrograms/kg-1 min-1). Alprostadil 62-66 CD59 molecule (CD59 blood group) Homo sapiens 91-96 7044465-4 1982 PGE1 0.1-0.2 ng kg-1 body weight min-1 was administered. Alprostadil 0-4 CD59 molecule (CD59 blood group) Homo sapiens 33-38