PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11298499-2 2001 The effects of in vitro exposure of brain (target) and serum (biomarker) ChE to chlorpyrifos-oxon (C horizontal lineO) and azinphos-methyl-oxon (AZM horizontal lineO), the active metabolites of the insecticides chlorpyrifos and azinphos-methyl, respectively, were investigated to determine if simultaneous or sequential exposure to these two OP compounds results in purely additive effects. Chlorpyrifos 80-92 butyrylcholinesterase Homo sapiens 73-76 28467056-9 2017 The detection limits for diazinon(oxon) and chlorpyrifos(oxon) were estimated to be as low as 6 x 10-12 M and 8 x 10-12 M, respectively, after 20 min of preincubation with these irreversible inhibitors of BChE. Chlorpyrifos 44-56 butyrylcholinesterase Homo sapiens 205-209 10429680-12 1999 After a thorough review of the experimental animal literature, it was determined that the chlorpyrifos repeated-exposure RfD based on application of a 100-fold uncertainty factor on the no observed adverse effects level (NOAEL) for brain cholinesterase inhibition or on a 10-fold uncertainty factor on the NOAEL for erythrocyte cholinesterase inhibition is 0.01 mg/kg/d. Chlorpyrifos 90-102 butyrylcholinesterase Homo sapiens 238-252 10429680-12 1999 After a thorough review of the experimental animal literature, it was determined that the chlorpyrifos repeated-exposure RfD based on application of a 100-fold uncertainty factor on the no observed adverse effects level (NOAEL) for brain cholinesterase inhibition or on a 10-fold uncertainty factor on the NOAEL for erythrocyte cholinesterase inhibition is 0.01 mg/kg/d. Chlorpyrifos 90-102 butyrylcholinesterase Homo sapiens 328-342 8896566-8 1996 The insecticides parathion, chlorpyrifos and diazinon are bioactivated to potent cholinesterase inhibitors by cytochrome P-450 systems. Chlorpyrifos 28-40 butyrylcholinesterase Homo sapiens 81-95 31841723-9 2020 Acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and 3,5,6-trichloro-2-pyridinol (TCP-y), specific for Chlorpyrifos, were among the most common biomarkers identified; however, most metabolites found were non-specific. Chlorpyrifos 113-125 butyrylcholinesterase Homo sapiens 52-57 28467056-8 2017 The SPE-MnO2/MG/BChE biosensor enabled precision detection of organophosphorus pesticides (diazinon(oxon), chlorpyrifos(oxon)) in aqueous samples with minimized interference from extraneous (nonanalyte) substances (e.g., ions of heavy metals). Chlorpyrifos 107-119 butyrylcholinesterase Homo sapiens 16-20 10931542-11 2000 The validated procedures provide excellent tools for the specific assessment of occupational exposure to the organophosphorus pesticide chlorpyrifos, throughout the analysis of both human serum and urine, and it is more selective and sensitive than the current assay based on the measurement of the decrease in the cholinesterase activity. Chlorpyrifos 136-148 butyrylcholinesterase Homo sapiens 315-329 2484042-12 1989 It is suggested that a decrease in plasma cholinesterase activity occurs due to chlorpyrifos exposure. Chlorpyrifos 80-92 butyrylcholinesterase Homo sapiens 42-56 33910290-0 2021 [Factors affecting the recovery of cholinesterase activity in patients with acute chlorpyrifos poisoning]. Chlorpyrifos 82-94 butyrylcholinesterase Homo sapiens 35-49 33910290-1 2021 Objective: To investigate the related factors affecting the recovery of cholinesterase (ChE) activity in patients with acute chlorpyrifos poisoning. Chlorpyrifos 125-137 butyrylcholinesterase Homo sapiens 72-86 33910290-1 2021 Objective: To investigate the related factors affecting the recovery of cholinesterase (ChE) activity in patients with acute chlorpyrifos poisoning. Chlorpyrifos 125-137 butyrylcholinesterase Homo sapiens 88-91 33910290-7 2021 Conclusion: The recovery of serum ChE activity in patients with acute chlorpyrifos poisoning is very slow. Chlorpyrifos 70-82 butyrylcholinesterase Homo sapiens 34-37 33910290-8 2021 Hemoperfusion can quickly remove chlorpyrifos, its metabolites and inflammatory mediators in the blood, thus effectively promoting the recovery of ChE activity. Chlorpyrifos 33-45 butyrylcholinesterase Homo sapiens 147-150 29736246-4 2018 Results showed that Chlorpyrifos significantly (P < .05) reduced the levels of cholinesterase both in plasma and on red blood cells. Chlorpyrifos 20-32 butyrylcholinesterase Homo sapiens 82-96 29736246-5 2018 Red blood cells Na+/K+ ATPase and Ca2+ ATPase were also significantly (P < .05) reduced by chlorpyrifos while MgCl2 counteracted effects of chlorpyrifos with significant (P < .05) increase in the levels of cholinesterase, Na+/K+ ATPase and Ca2+ ATPase. Chlorpyrifos 94-106 butyrylcholinesterase Homo sapiens 212-226 29736246-5 2018 Red blood cells Na+/K+ ATPase and Ca2+ ATPase were also significantly (P < .05) reduced by chlorpyrifos while MgCl2 counteracted effects of chlorpyrifos with significant (P < .05) increase in the levels of cholinesterase, Na+/K+ ATPase and Ca2+ ATPase. Chlorpyrifos 143-155 butyrylcholinesterase Homo sapiens 212-226 25543108-0 2015 Derivation of human Biomonitoring Guidance Values for chlorpyrifos using a physiologically based pharmacokinetic and pharmacodynamic model of cholinesterase inhibition. Chlorpyrifos 54-66 butyrylcholinesterase Homo sapiens 142-156 24200834-7 2014 At oral doses >=0.6mg/kg of chlorpyrifos (100- to 1000-fold higher than environmental exposure levels), 6months old children are predicted to have higher levels of chlorpyrifos-oxon in blood and higher levels of red blood cell cholinesterase inhibition compared to adults from equivalent doses. Chlorpyrifos 31-43 butyrylcholinesterase Homo sapiens 230-244 24833556-3 2014 The objectives of this study are to estimate exposures to the organophosphorus pesticide, chlorpyrifos (CPF), by measuring urinary levels of 3,5,6-trichloro-2-pyridinol (TCPy), a specific CPF metabolite, and blood cholinesterase (ChE) activities and to characterize neurobehavioral performance in adolescents working as seasonal pesticide applicators and non-applicator controls. Chlorpyrifos 90-102 butyrylcholinesterase Homo sapiens 214-228 24833556-3 2014 The objectives of this study are to estimate exposures to the organophosphorus pesticide, chlorpyrifos (CPF), by measuring urinary levels of 3,5,6-trichloro-2-pyridinol (TCPy), a specific CPF metabolite, and blood cholinesterase (ChE) activities and to characterize neurobehavioral performance in adolescents working as seasonal pesticide applicators and non-applicator controls. Chlorpyrifos 90-102 butyrylcholinesterase Homo sapiens 230-233 24833556-3 2014 The objectives of this study are to estimate exposures to the organophosphorus pesticide, chlorpyrifos (CPF), by measuring urinary levels of 3,5,6-trichloro-2-pyridinol (TCPy), a specific CPF metabolite, and blood cholinesterase (ChE) activities and to characterize neurobehavioral performance in adolescents working as seasonal pesticide applicators and non-applicator controls. Chlorpyrifos 104-107 butyrylcholinesterase Homo sapiens 214-228 24833556-3 2014 The objectives of this study are to estimate exposures to the organophosphorus pesticide, chlorpyrifos (CPF), by measuring urinary levels of 3,5,6-trichloro-2-pyridinol (TCPy), a specific CPF metabolite, and blood cholinesterase (ChE) activities and to characterize neurobehavioral performance in adolescents working as seasonal pesticide applicators and non-applicator controls. Chlorpyrifos 104-107 butyrylcholinesterase Homo sapiens 230-233 22446730-1 2012 This paper evaluates new data for cholinesterase inhibition with chlorpyrifos (CPF). Chlorpyrifos 65-77 butyrylcholinesterase Homo sapiens 34-48 23524272-7 2013 Therefore, regulatory exposure limits for chlorpyrifos, which are based on cholinesterase inhibition, are sufficient to protect against potential endocrine alterations. Chlorpyrifos 42-54 butyrylcholinesterase Homo sapiens 75-89 23590812-0 2013 Chlorpyrifos is associated with slower serum cholinesterase recovery in acute organophosphate-poisoned patients. Chlorpyrifos 0-12 butyrylcholinesterase Homo sapiens 45-59 22446730-1 2012 This paper evaluates new data for cholinesterase inhibition with chlorpyrifos (CPF). Chlorpyrifos 79-82 butyrylcholinesterase Homo sapiens 34-48 18716607-0 2009 Cholinesterase inhibition in chlorpyrifos workers: Characterization of biomarkers of exposure and response in relation to urinary TCPy. Chlorpyrifos 29-41 butyrylcholinesterase Homo sapiens 0-14 21722690-2 2011 This model was used to investigate cholinesterase inhibition from dietary exposures to an insecticide (chlorpyrifos) in populations of adults and 3 year old children. Chlorpyrifos 103-115 butyrylcholinesterase Homo sapiens 35-49 20395308-7 2010 A fourth patient whose BChE activity was inhibited 60% by exposure to chlorpyrifos had no detectable adduct on albumin. Chlorpyrifos 70-82 butyrylcholinesterase Homo sapiens 23-27 18716607-1 2009 The objective of this study was to evaluate the quantitative relation between measured red blood cell acetylcholinesterase (RBC AChE) and plasma butyrylcholinesterase (BuChE) activities with exposure to chlorpyrifos (CPF) as assessed by measurement of urinary 3,5,6-trichloro-2-pyridinol (TCPy) in a study group of workers occupationally exposed in the manufacture of CPF and a referent group of chemical manufacturing workers. Chlorpyrifos 203-215 butyrylcholinesterase Homo sapiens 145-166 18716607-1 2009 The objective of this study was to evaluate the quantitative relation between measured red blood cell acetylcholinesterase (RBC AChE) and plasma butyrylcholinesterase (BuChE) activities with exposure to chlorpyrifos (CPF) as assessed by measurement of urinary 3,5,6-trichloro-2-pyridinol (TCPy) in a study group of workers occupationally exposed in the manufacture of CPF and a referent group of chemical manufacturing workers. Chlorpyrifos 203-215 butyrylcholinesterase Homo sapiens 168-173 18716607-1 2009 The objective of this study was to evaluate the quantitative relation between measured red blood cell acetylcholinesterase (RBC AChE) and plasma butyrylcholinesterase (BuChE) activities with exposure to chlorpyrifos (CPF) as assessed by measurement of urinary 3,5,6-trichloro-2-pyridinol (TCPy) in a study group of workers occupationally exposed in the manufacture of CPF and a referent group of chemical manufacturing workers. Chlorpyrifos 217-220 butyrylcholinesterase Homo sapiens 145-166 18716607-1 2009 The objective of this study was to evaluate the quantitative relation between measured red blood cell acetylcholinesterase (RBC AChE) and plasma butyrylcholinesterase (BuChE) activities with exposure to chlorpyrifos (CPF) as assessed by measurement of urinary 3,5,6-trichloro-2-pyridinol (TCPy) in a study group of workers occupationally exposed in the manufacture of CPF and a referent group of chemical manufacturing workers. Chlorpyrifos 217-220 butyrylcholinesterase Homo sapiens 168-173 18716607-1 2009 The objective of this study was to evaluate the quantitative relation between measured red blood cell acetylcholinesterase (RBC AChE) and plasma butyrylcholinesterase (BuChE) activities with exposure to chlorpyrifos (CPF) as assessed by measurement of urinary 3,5,6-trichloro-2-pyridinol (TCPy) in a study group of workers occupationally exposed in the manufacture of CPF and a referent group of chemical manufacturing workers. Chlorpyrifos 368-371 butyrylcholinesterase Homo sapiens 145-166 18716607-1 2009 The objective of this study was to evaluate the quantitative relation between measured red blood cell acetylcholinesterase (RBC AChE) and plasma butyrylcholinesterase (BuChE) activities with exposure to chlorpyrifos (CPF) as assessed by measurement of urinary 3,5,6-trichloro-2-pyridinol (TCPy) in a study group of workers occupationally exposed in the manufacture of CPF and a referent group of chemical manufacturing workers. Chlorpyrifos 368-371 butyrylcholinesterase Homo sapiens 168-173 18072155-17 2007 Using the modified electrometric method, various percentages of cholinesterase inhibitions in the plasma, erythrocytes, and whole blood were detected after in vitro addition of the organophosphate insecticides (chlorpyrifos and methidathion) and the carbamate insecticide (carbaryl) to the reaction mixtures. Chlorpyrifos 211-223 butyrylcholinesterase Homo sapiens 64-78 18375477-7 2008 RESULTS: The usefulness of a plasma BuChE activity <600 mU/ml on admission varied markedly--while highly sensitive in chlorpyrifos poisoning (sensitivity 11/11 deaths; 100%, 95% CI 71.5-100), its specificity was only 17.7% (12.6-23.7). Chlorpyrifos 121-133 butyrylcholinesterase Homo sapiens 36-41 18726789-3 2008 Current "background" (nonoccupational) levels of exposure to chlorpyrifos are several orders of magnitude lower than those required to inhibit plasma cholinesterase activity, which is a more sensitive target than nervous system cholinesterase. Chlorpyrifos 61-73 butyrylcholinesterase Homo sapiens 150-164 18617161-1 2008 Organophosphorus pesticides (e.g. chlorpyrifos, malathion, and parathion) and nerve agents (sarin, tabun, and VX) are highly toxic organophosphorus compounds with strong inhibition potency against two key enzymes in the human body-acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BuChE; EC 3.1.1.8). Chlorpyrifos 34-46 butyrylcholinesterase Homo sapiens 275-296 18617161-1 2008 Organophosphorus pesticides (e.g. chlorpyrifos, malathion, and parathion) and nerve agents (sarin, tabun, and VX) are highly toxic organophosphorus compounds with strong inhibition potency against two key enzymes in the human body-acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BuChE; EC 3.1.1.8). Chlorpyrifos 34-46 butyrylcholinesterase Homo sapiens 298-303 18155347-10 2008 Taken collectively, these results suggest that chlorpyrifos induces apoptosis in placental cells through pathways not dependent on FAS/TNF signaling, activation of caspases or inhibition of cholinesterase. Chlorpyrifos 47-59 butyrylcholinesterase Homo sapiens 190-204 15896443-1 2005 Chlorpyrifos is an irreversible inhibitor of cholinesterase (ChE), and inhibition of ChE is believed to be the most sensitive effect in all animal species evaluated and in humans. Chlorpyrifos 0-12 butyrylcholinesterase Homo sapiens 45-59 16360256-1 2006 Chlorpyrifos is an inhibitor of cholinesterase (ChE) and inhibition of ChE is believed to be the most sensitive effect in all animal species evaluated and in humans from previous evaluations. Chlorpyrifos 0-12 butyrylcholinesterase Homo sapiens 32-46 16360256-1 2006 Chlorpyrifos is an inhibitor of cholinesterase (ChE) and inhibition of ChE is believed to be the most sensitive effect in all animal species evaluated and in humans from previous evaluations. Chlorpyrifos 0-12 butyrylcholinesterase Homo sapiens 48-51 16360256-1 2006 Chlorpyrifos is an inhibitor of cholinesterase (ChE) and inhibition of ChE is believed to be the most sensitive effect in all animal species evaluated and in humans from previous evaluations. Chlorpyrifos 0-12 butyrylcholinesterase Homo sapiens 71-74 15896443-4 2005 We analyze the available information from epidemiology studies and animal studies in order to identify the relative sensitivity of decreased birth weight and inhibition of ChE from exposure to chlorpyrifos. Chlorpyrifos 193-205 butyrylcholinesterase Homo sapiens 172-175 15896443-13 2005 Moreover, the critical effect for chlorpyrifos still appears to be cholinesterase inhibition. Chlorpyrifos 34-46 butyrylcholinesterase Homo sapiens 67-81 15896443-1 2005 Chlorpyrifos is an irreversible inhibitor of cholinesterase (ChE), and inhibition of ChE is believed to be the most sensitive effect in all animal species evaluated and in humans. Chlorpyrifos 0-12 butyrylcholinesterase Homo sapiens 61-64 12242675-4 2002 Cholinesterase activity in male spiders was inhibited to 14% and 61% of control activity by Basudin and Lorsban, respectively. Chlorpyrifos 104-111 butyrylcholinesterase Homo sapiens 0-14 15802843-0 2005 Spectrophotometric determination of plasma and red blood cell cholinesterase activity of 53 fruit farm workers pre- and post-exposed chlorpyrifos for one fruit crop. Chlorpyrifos 133-145 butyrylcholinesterase Homo sapiens 62-76 15802843-1 2005 We sought to investigate the early biological effects of chlorpyrifos among 53 Thai fruit farm workers by measuring the plasma cholinesterase (PChE) and red blood cell cholinesterase (AChE) activities, a biomarker of organophosphate (OPs) pesticide during one fruit crop. Chlorpyrifos 57-69 butyrylcholinesterase Homo sapiens 127-141 14985514-4 2004 RESULTS: Chlorpyrifos and referent groups differed significantly in measures of 3,5,6 trichloro-2-pyridinol excretion and plasma butyrylcholinesterase (BuChE) activity, indicating substantially higher exposures among chlorpyrifos subjects. Chlorpyrifos 9-21 butyrylcholinesterase Homo sapiens 129-150 14985514-4 2004 RESULTS: Chlorpyrifos and referent groups differed significantly in measures of 3,5,6 trichloro-2-pyridinol excretion and plasma butyrylcholinesterase (BuChE) activity, indicating substantially higher exposures among chlorpyrifos subjects. Chlorpyrifos 9-21 butyrylcholinesterase Homo sapiens 152-157 14985514-10 2004 CONCLUSIONS: Chronic chlorpyrifos exposure during the manufacturing process sufficient to produce biological effects on BuChE activity was not associated with clinically evident or subclinical peripheral neuropathy at baseline or with measurable deterioration among chlorpyrifos subjects compared to referents after one year of additional exposure. Chlorpyrifos 21-33 butyrylcholinesterase Homo sapiens 120-125