PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27581370-6	2016	Furthermore, we also found that bumetanide (BU), an inhibitor of NKCC1, inhibited trauma-induced AQP4 upregulation (p < 0.05).	Bumetanide	32-42	aquaporin 4	Mus musculus	97-101	
27581370-6	2016	Furthermore, we also found that bumetanide (BU), an inhibitor of NKCC1, inhibited trauma-induced AQP4 upregulation (p < 0.05).	Bumetanide	44-46	aquaporin 4	Mus musculus	97-101	
20458553-4	2010	We tested the hypothesis that the perivascular pool of AQP4 plays a significant role in the anti-edema effect of bumetanide by utilizing wild-type (WT) mice as well as mice with targeted disruption of alpha-syntrophin (alpha-Syn(-/-)) that lack the perivascular pool of AQP4.	Bumetanide	113-123	aquaporin 4	Mus musculus	55-59	
20458553-10	2010	Bumetanide-treated WT mice had a significant attenuation of AQP4 protein expression at 48 h post-MCAO compared to vehicle-treated WT mice.	Bumetanide	0-10	aquaporin 4	Mus musculus	60-64	
20458553-11	2010	CONCLUSIONS: These data suggest that bumetanide exerts its neuroprotective and anti-edema effects partly via blockade of the perivascular pool of AQP4 and may have therapeutic potential for ischemic stroke in the clinical setting.	Bumetanide	37-47	aquaporin 4	Mus musculus	146-150