PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22685291-6	2012	Interestingly, gemfibrozil induced the activation of type IA phosphatidylinositol (PI) 3-kinase and AKT.	Gemfibrozil	15-26	thymoma viral proto-oncogene 1	Mus musculus	100-103	
22685291-7	2012	Accordingly, inhibition of PI 3-kinase and AKT by chemical inhibitors abrogated gemfibrozil-mediated up-regulation of SOCS3.	Gemfibrozil	80-91	thymoma viral proto-oncogene 1	Mus musculus	43-46	
22685291-8	2012	Furthermore, we demonstrated that gemfibrozil induced the activation of Kruppel-like factor 4 (KLF4) via the PI 3-kinase-AKT pathway and that siRNA knockdown of KLF4 abrogated gemfibrozil-mediated up-regulation of SOCS3.	Gemfibrozil	34-45	thymoma viral proto-oncogene 1	Mus musculus	121-124	
22685291-10	2012	This study delineates a novel property of gemfibrozil in up-regulating SOCS3 in glial cells via PI 3-kinase-AKT-mediated activation of KLF4 and suggests that gemfibrozil may find therapeutic application in neuroinflammatory and neurodegenerative disorders.	Gemfibrozil	42-53	thymoma viral proto-oncogene 1	Mus musculus	108-111	
22685291-10	2012	This study delineates a novel property of gemfibrozil in up-regulating SOCS3 in glial cells via PI 3-kinase-AKT-mediated activation of KLF4 and suggests that gemfibrozil may find therapeutic application in neuroinflammatory and neurodegenerative disorders.	Gemfibrozil	158-169	thymoma viral proto-oncogene 1	Mus musculus	108-111	
22706077-6	2012	Activation of type IA p110alpha PI3K and Akt by gem and abrogation of gem-induced upregulation of IL-1Ra by inhibitors of PI3K and Akt indicate a role of the PI3K-Akt pathway in the upregulation of IL-1Ra.	Gemfibrozil	48-51	thymoma viral proto-oncogene 1	Mus musculus	41-44	
22706077-6	2012	Activation of type IA p110alpha PI3K and Akt by gem and abrogation of gem-induced upregulation of IL-1Ra by inhibitors of PI3K and Akt indicate a role of the PI3K-Akt pathway in the upregulation of IL-1Ra.	Gemfibrozil	70-73	thymoma viral proto-oncogene 1	Mus musculus	131-134	
22706077-6	2012	Activation of type IA p110alpha PI3K and Akt by gem and abrogation of gem-induced upregulation of IL-1Ra by inhibitors of PI3K and Akt indicate a role of the PI3K-Akt pathway in the upregulation of IL-1Ra.	Gemfibrozil	70-73	thymoma viral proto-oncogene 1	Mus musculus	131-134