PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20208386-4 2010 Studies with HLM under-predict the ability of gemfibrozil and bupropion to cause clinically significant inhibition of CYP2C8 and CYP2D6, respectively, and over-predict the ability of ezetimibe to cause clinically significant inhibition of CYP3A4. Gemfibrozil 46-57 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 129-135 20208386-5 2010 Gemfibrozil and bupropion represent examples of glucuronidation-dependent and reduction-dependent activation to metabolites that inhibit CYP2C8 and CYP2D6, respectively, whereas ezetimibe represents an example of glucuronidation-dependent protection against metabolism-dependent inhibition of CYP3A4. Gemfibrozil 0-11 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 148-154