PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28199020-5 2017 Therefore, we administered gemfibrozil (gem), an food and drug administration (FDA)-approved lipid-lowering drug, which has been shown to stimulate lysosomal biogenesis and induce anti-inflammation, orally, at a dose of 7.5 mg/kg body wt/day to Cln2(-/-) mice. Gemfibrozil 27-38 tripeptidyl peptidase I Mus musculus 245-249 28199020-6 2017 We observed that gem-fed Cln2(-/-) mice lived longer by more than 10 weeks and had better motor activity compared to vehicle (0.1% Methyl cellulose) treatment. Gemfibrozil 17-20 tripeptidyl peptidase I Mus musculus 25-29 22989886-0 2012 Gemfibrozil and fenofibrate, Food and Drug Administration-approved lipid-lowering drugs, up-regulate tripeptidyl-peptidase 1 in brain cells via peroxisome proliferator-activated receptor alpha: implications for late infantile Batten disease therapy. Gemfibrozil 0-11 tripeptidyl peptidase I Mus musculus 101-124 22989886-4 2012 This study reveals a novel use of gemfibrozil and fenofibrate, Food and Drug Administration-approved lipid-lowering drugs, in up-regulating TPP1 in brain cells. Gemfibrozil 34-45 tripeptidyl peptidase I Mus musculus 140-144 22989886-5 2012 Both gemfibrozil and fenofibrate up-regulated mRNA, protein, and enzymatic activity of TPP1 in primary mouse neurons and astrocytes as well as human astrocytes and neuronal cells. Gemfibrozil 5-16 tripeptidyl peptidase I Mus musculus 87-91 22989886-8 2012 Accordingly, all-trans-retinoic acid, alone or together with gemfibrozil, up-regulated TPP1. Gemfibrozil 61-72 tripeptidyl peptidase I Mus musculus 87-91