PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22528839-4	2012	This study underlines the importance of PPARbeta/delta in mediating the anti-inflammatory effect of gemfibrozil, an FDA-approved lipid-lowering drug, in primary human microglia.	Gemfibrozil	100-111	peroxisome proliferator activated receptor delta	Homo sapiens	40-48	
22879602-0	2012	Gemfibrozil, a lipid-lowering drug, increases myelin genes in human oligodendrocytes via peroxisome proliferator-activated receptor-beta.	Gemfibrozil	0-11	peroxisome proliferator activated receptor delta	Homo sapiens	89-136	
22879602-5	2012	On the other hand, gemfibrozil markedly increased the expression of PPAR-beta but not PPAR-gamma.	Gemfibrozil	19-30	peroxisome proliferator activated receptor delta	Homo sapiens	68-77	
22879602-6	2012	Consistently, antisense knockdown of PPAR-beta, but not PPAR-gamma, abrogated the stimulatory effect of gemfibrozil on myelin genes in human oligodendrocytes.	Gemfibrozil	104-115	peroxisome proliferator activated receptor delta	Homo sapiens	37-46	
22879602-8	2012	Chromatin immunoprecipitation analysis showed that gemfibrozil induced the recruitment of PPAR-beta to the promoter of PLP and myelin oligodendrocyte glycoprotein genes in human oligodendrocytes.	Gemfibrozil	51-62	peroxisome proliferator activated receptor delta	Homo sapiens	90-99	
22879602-10	2012	These results suggest that gemfibrozil stimulates the expression of myelin genes via PPAR-beta and that gemfibrozil, a prescribed drug for humans, may find further therapeutic use in demyelinating diseases.	Gemfibrozil	27-38	peroxisome proliferator activated receptor delta	Homo sapiens	85-94	
22528839-8	2012	Interestingly, either antisense knockdown of PPAR-beta or antagonism of PPAR-beta by a specific chemical antagonist abrogated gemfibrozil-mediated inhibition of microglial activation.	Gemfibrozil	126-137	peroxisome proliferator activated receptor delta	Homo sapiens	45-54	
22528839-8	2012	Interestingly, either antisense knockdown of PPAR-beta or antagonism of PPAR-beta by a specific chemical antagonist abrogated gemfibrozil-mediated inhibition of microglial activation.	Gemfibrozil	126-137	peroxisome proliferator activated receptor delta	Homo sapiens	72-81	
22528839-10	2012	These results highlight the fact that gemfibrozil regulates microglial activation by inhibiting inflammatory gene expression in a PPAR-beta dependent pathway and further reinforce its therapeutic application in several neuroinflammatory and neurodegenerative diseases.	Gemfibrozil	38-49	peroxisome proliferator activated receptor delta	Homo sapiens	130-139	
18356690-5	2008	While fenofibrate and LY518674 showed exclusive dependency on PPARalpha for these activities, bezafibrate and gemfibrozil exhibited dependency on PPARbeta/delta and PPARgamma as well.	Gemfibrozil	110-121	peroxisome proliferator activated receptor delta	Homo sapiens	146-154