PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28270124-0	2017	Cyproterone acetate enhances TRAIL-induced androgen-independent prostate cancer cell apoptosis via up-regulation of death receptor 5.	Cyproterone Acetate	0-19	TNF receptor superfamily member 10b	Homo sapiens	116-132	
28270124-9	2017	Further investigation of the TRAIL-induced apoptosis pathway revealed that cyproterone acetate exerted its effect by selectively increasing death receptor 5 (DR5) mRNA and protein expression.	Cyproterone Acetate	75-94	TNF receptor superfamily member 10b	Homo sapiens	140-156	
28270124-9	2017	Further investigation of the TRAIL-induced apoptosis pathway revealed that cyproterone acetate exerted its effect by selectively increasing death receptor 5 (DR5) mRNA and protein expression.	Cyproterone Acetate	75-94	TNF receptor superfamily member 10b	Homo sapiens	158-161	
28270124-10	2017	Cyproterone acetate treatment also increased DR5 gene promoter activity, which could be abolished by mutation of a consensus binding domain of transcription factor CCAAT-enhancer-binding protein homologous protein (CHOP) in the DR5 gene promoter.	Cyproterone Acetate	0-19	TNF receptor superfamily member 10b	Homo sapiens	45-48	
28270124-10	2017	Cyproterone acetate treatment also increased DR5 gene promoter activity, which could be abolished by mutation of a consensus binding domain of transcription factor CCAAT-enhancer-binding protein homologous protein (CHOP) in the DR5 gene promoter.	Cyproterone Acetate	0-19	TNF receptor superfamily member 10b	Homo sapiens	228-231	
28270124-11	2017	Cyproterone acetate increases CHOP expression in a concentration and time-dependent manner and endoplasmic reticulum stress reducer 4-phenylbutyrate could block cyproterone acetate-induced CHOP and DR5 up-regulation.	Cyproterone Acetate	0-19	TNF receptor superfamily member 10b	Homo sapiens	198-201	
28270124-11	2017	Cyproterone acetate increases CHOP expression in a concentration and time-dependent manner and endoplasmic reticulum stress reducer 4-phenylbutyrate could block cyproterone acetate-induced CHOP and DR5 up-regulation.	Cyproterone Acetate	161-180	TNF receptor superfamily member 10b	Homo sapiens	198-201	
28270124-12	2017	More importantly, siRNA silencing of CHOP significantly reduced cyproterone acetate-induced DR5 up-regulation and TRAIL sensitivity in prostate cancer cells.	Cyproterone Acetate	64-83	TNF receptor superfamily member 10b	Homo sapiens	92-95