PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16644100-3 2006 Although the CGbeta subunit containing the CTP domain is expressed only in primates and equids, a CTP-like sequence exists in the untranslated region of the LHbeta gene of several mammalian species, including the bovine species. Cytidine Triphosphate 43-46 chorionic gonadotropin subunit beta 3 Homo sapiens 13-19 17092639-2 2007 CGbeta genes from the human being and horse have evolved from ancestral luteinizing hormone (LH) beta genes by different pathways that involve deletions that change the reading frames and yield a CTP. Cytidine Triphosphate 196-199 chorionic gonadotropin subunit beta 3 Homo sapiens 0-6 17092639-4 2007 In multiple mammalian species, simple frame-shift mutations using either the human or equine CGbeta gene as a model can be used to construct LHbeta analogs with putative CTP domains. Cytidine Triphosphate 170-173 chorionic gonadotropin subunit beta 3 Homo sapiens 93-99 17092639-5 2007 Furthermore, DNA sequences from mammalian LHbeta genes can be aligned to maximize similarity with CGbeta genes in order to devise more refined strategies for construction of CTP-bearing LHbeta analogs as exemplified in the bovine case. Cytidine Triphosphate 174-177 chorionic gonadotropin subunit beta 3 Homo sapiens 98-104 11018759-2 2000 Like the hCG beta, the equine eLH and eCG beta subunits, also possess a C-terminal extension (CTP). Cytidine Triphosphate 94-97 chorionic gonadotropin subunit beta 3 Homo sapiens 9-17 16527410-6 2006 CGbeta subunit is distinguished among the beta subunits because of the presence of a carboxyl-terminal peptide (CTP) bearing four O-linked oligosaccharide chains. Cytidine Triphosphate 112-115 chorionic gonadotropin subunit beta 3 Homo sapiens 0-6 16636974-2 2006 In tethered human (h) gonadotropins, the carboxyl terminal peptide (CTP) of the choriogonadotropin (CG) beta subunit serves as an effective linker to enhance the secretion of the analogs compared to variants lacking the CTP. Cytidine Triphosphate 68-71 chorionic gonadotropin subunit beta 3 Homo sapiens 80-108 16636974-11 2006 Thus, the hCGbeta CTP maintains pro-secretory determinants without inhibiting receptor activation when applied as a linker in tethered bovine LH, implying that these CTP features are preserved when the domain is incorporated into non-primate single chain analogs. Cytidine Triphosphate 18-21 chorionic gonadotropin subunit beta 3 Homo sapiens 10-17 16636974-11 2006 Thus, the hCGbeta CTP maintains pro-secretory determinants without inhibiting receptor activation when applied as a linker in tethered bovine LH, implying that these CTP features are preserved when the domain is incorporated into non-primate single chain analogs. Cytidine Triphosphate 166-169 chorionic gonadotropin subunit beta 3 Homo sapiens 10-17 15723833-8 2005 This deficiency was further confirmed when the boCTP domain was substituted for the natural CTP in the human CGbeta subunit. Cytidine Triphosphate 49-52 chorionic gonadotropin subunit beta 3 Homo sapiens 109-115 16011249-7 2005 We found that CTP quadrigeminum had similar secondary structure with hCGbeta, but the speciality of antigen better than that of the latter. Cytidine Triphosphate 14-17 chorionic gonadotropin subunit beta 3 Homo sapiens 69-76 15165483-10 2004 The G5M1 MAb reacts only with hCGbeta, hCGbeta-CTP and intact hCG with no detectable cross-reaction with hCGalpha or any of the other glycoprotein hormones. Cytidine Triphosphate 47-50 chorionic gonadotropin subunit beta 3 Homo sapiens 39-46 10614624-5 2000 Herein, we report the construction of a new single chain hCG analog (YhCG3) in which the C-terminus of the alpha-subunit is fused to the N-terminus of hCGbeta via a CTP (N-alpha-CTP-beta-C). Cytidine Triphosphate 165-168 chorionic gonadotropin subunit beta 3 Homo sapiens 151-158 10548880-4 1999 The CG beta subunit contains a carboxy-terminal extension (CTP) with four serine O-linked oligosaccharides, which is important for the long half-life of hCG. Cytidine Triphosphate 59-62 chorionic gonadotropin subunit beta 3 Homo sapiens 4-11 12687122-2 1999 I have detected hitherto unreported identity of HCG-beta sequence with tetrapeptides of PECAM-1, galactosyl transferase-associated protein kinase, insulin receptor-related receptor and carboxypeptidase E. A predicted potential epitope of C-terminal peptide (CTP) of HCG-beta was identical to a tetrapeptide stretch of MCSF-1. Cytidine Triphosphate 258-261 chorionic gonadotropin subunit beta 3 Homo sapiens 48-56 1379674-6 1992 The eLH/CG beta gene spans less than 1.2 kilobase-pairs and has three exons that translate a CTP-containing polypeptide identical in sequence to that previously reported for the mature equine protein. Cytidine Triphosphate 93-96 chorionic gonadotropin subunit beta 3 Homo sapiens 8-15 8961276-7 1996 Fusion of this heptapeptide to CG beta 114, i.e. CG beta lacking the CTP, decreased the amount of secreted subunit 2-fold compared with wild type human CG beta. Cytidine Triphosphate 69-72 chorionic gonadotropin subunit beta 3 Homo sapiens 31-38 8961276-7 1996 Fusion of this heptapeptide to CG beta 114, i.e. CG beta lacking the CTP, decreased the amount of secreted subunit 2-fold compared with wild type human CG beta. Cytidine Triphosphate 69-72 chorionic gonadotropin subunit beta 3 Homo sapiens 49-56 8961276-7 1996 Fusion of this heptapeptide to CG beta 114, i.e. CG beta lacking the CTP, decreased the amount of secreted subunit 2-fold compared with wild type human CG beta. Cytidine Triphosphate 69-72 chorionic gonadotropin subunit beta 3 Homo sapiens 49-56 1379674-7 1992 There is, however, little amino acid homology shown between the CTP of human or equine CG beta subunit. Cytidine Triphosphate 64-67 chorionic gonadotropin subunit beta 3 Homo sapiens 87-94 9027345-7 1996 (The CTP sequence is the last 28 amino acids of the CG beta sequence and contains four serine-linked oligosaccharides). Cytidine Triphosphate 5-8 chorionic gonadotropin subunit beta 3 Homo sapiens 52-59 7539107-1 1995 The hCG beta-subunit contains a carboxy-terminal extension bearing four serine-linked oligosaccharides [carboxy-terminal peptide (CTP)], which is important for maintaining its longer half-life compared with the other glycoprotein hormones. Cytidine Triphosphate 130-133 chorionic gonadotropin subunit beta 3 Homo sapiens 4-12 2834473-5 1988 Western blotting using anti-hCG beta-carboxy-terminal peptides (CTP) revealed a single band corresponding to hCG beta. Cytidine Triphosphate 64-67 chorionic gonadotropin subunit beta 3 Homo sapiens 28-36 2482285-7 1989 In the Western blot using anti-hCGbeta or anti-hCGbeta-CTP under reducing conditions, the urine presented a new band (CTP") with Mr 23,000 in addition to the beta-subunit, while the serum revealed a single band of the beta-subunit with or without a reducing reagent. Cytidine Triphosphate 55-58 chorionic gonadotropin subunit beta 3 Homo sapiens 47-54 2482285-7 1989 In the Western blot using anti-hCGbeta or anti-hCGbeta-CTP under reducing conditions, the urine presented a new band (CTP") with Mr 23,000 in addition to the beta-subunit, while the serum revealed a single band of the beta-subunit with or without a reducing reagent. Cytidine Triphosphate 118-121 chorionic gonadotropin subunit beta 3 Homo sapiens 31-38 2482285-7 1989 In the Western blot using anti-hCGbeta or anti-hCGbeta-CTP under reducing conditions, the urine presented a new band (CTP") with Mr 23,000 in addition to the beta-subunit, while the serum revealed a single band of the beta-subunit with or without a reducing reagent. Cytidine Triphosphate 118-121 chorionic gonadotropin subunit beta 3 Homo sapiens 47-54 2452075-16 1988 Since the sialylated peptide beta 115-141 binds poorly to it, this antiserum resembles the carbohydrate-oblivious anti-beta CTP; both require the COOH-terminal amino acids of hCG beta. Cytidine Triphosphate 124-127 chorionic gonadotropin subunit beta 3 Homo sapiens 175-183 2834473-5 1988 Western blotting using anti-hCG beta-carboxy-terminal peptides (CTP) revealed a single band corresponding to hCG beta. Cytidine Triphosphate 64-67 chorionic gonadotropin subunit beta 3 Homo sapiens 109-117 2426095-2 1986 Infusions of hCG beta, as-hCG, or intact hCG resulted in accumulation in the kidney of a large quantity of small mol wt peptides lacking the immunological determinants of the carboxy-terminal peptide (CTP) of the beta-subunit. Cytidine Triphosphate 201-204 chorionic gonadotropin subunit beta 3 Homo sapiens 13-21 2418956-3 1986 CTP-directed RIA recognized a peak of hCG beta-like immunoreactive material that eluted in the same position as standard hCG beta. Cytidine Triphosphate 0-3 chorionic gonadotropin subunit beta 3 Homo sapiens 38-46 2418956-3 1986 CTP-directed RIA recognized a peak of hCG beta-like immunoreactive material that eluted in the same position as standard hCG beta. Cytidine Triphosphate 0-3 chorionic gonadotropin subunit beta 3 Homo sapiens 121-129