PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30383537-7 2018 As the natural dehydrated product of PGD2, 15d-PGJ2 exerts inhibitory effects on the expression of APH-1alpha/1beta and PS1 in a peroxisome proliferator-activated receptor (PPAR) gamma-dependent manner. Prostaglandin D2 37-41 peroxisome proliferator activated receptor gamma Mus musculus 129-184 32290308-9 2020 GW9662, a peroxisome proliferator-activated receptor-gamma (PPARgamma) antagonist, suppressed PGD2-induced neurite outgrowth. Prostaglandin D2 94-98 peroxisome proliferator activated receptor gamma Mus musculus 10-58 32290308-9 2020 GW9662, a peroxisome proliferator-activated receptor-gamma (PPARgamma) antagonist, suppressed PGD2-induced neurite outgrowth. Prostaglandin D2 94-98 peroxisome proliferator activated receptor gamma Mus musculus 60-69 32290308-11 2020 These results suggest that PGD2 induces neuritogenesis in NSC-34 cells and that PGD2-induced neurite outgrowth was mediated by the activation of PPARgamma through the metabolite 15d-PGJ2. Prostaglandin D2 80-84 peroxisome proliferator activated receptor gamma Mus musculus 145-154 31704099-1 2019 The prostaglandin D2 metabolite, 15-deoxy-Delta12,14-Prostaglandin J2 (15d-PGJ2), exerts an anti-inflammatory effect through peroxisome proliferator-activated receptor gamma (PPARgamma)-dependent and -independent anti-inflammatory actions. Prostaglandin D2 4-20 peroxisome proliferator activated receptor gamma Mus musculus 125-173 31704099-1 2019 The prostaglandin D2 metabolite, 15-deoxy-Delta12,14-Prostaglandin J2 (15d-PGJ2), exerts an anti-inflammatory effect through peroxisome proliferator-activated receptor gamma (PPARgamma)-dependent and -independent anti-inflammatory actions. Prostaglandin D2 4-20 peroxisome proliferator activated receptor gamma Mus musculus 175-184 24917395-2 2014 It metabolizes PGD2 to 9alpha11beta-PGF2 , diverting the spontaneous conversion of PGD2 to the PPARgamma agonist, 15-Deoxy-Delta-12, 14-prostaglandin J2 (15d-PGJ2 ). Prostaglandin D2 15-19 peroxisome proliferator activated receptor gamma Mus musculus 95-104 24729479-4 2014 PGD2 metabolites bind to peroxisome proliferator-activated receptor gamma (PPARG). Prostaglandin D2 0-4 peroxisome proliferator activated receptor gamma Mus musculus 25-73 24729479-4 2014 PGD2 metabolites bind to peroxisome proliferator-activated receptor gamma (PPARG). Prostaglandin D2 0-4 peroxisome proliferator activated receptor gamma Mus musculus 75-80 24729479-5 2014 We hypothesized that Ptgdr or Pparg knockouts may raise numbers of tumors, if these receptors take part in tumor suppression by PGD2. Prostaglandin D2 128-132 peroxisome proliferator activated receptor gamma Mus musculus 30-35 24917395-2 2014 It metabolizes PGD2 to 9alpha11beta-PGF2 , diverting the spontaneous conversion of PGD2 to the PPARgamma agonist, 15-Deoxy-Delta-12, 14-prostaglandin J2 (15d-PGJ2 ). Prostaglandin D2 83-87 peroxisome proliferator activated receptor gamma Mus musculus 95-104 24917395-7 2014 Although attenuating AKR1C3 expression in SCC cells by siRNA did not affect growth, treatment with PGD2 and its dehydration metabolite, 15d-PGJ2 , decreased SCC proliferation in a PPARgamma-dependent manner. Prostaglandin D2 99-103 peroxisome proliferator activated receptor gamma Mus musculus 180-189 24917395-11 2014 This work suggests that PGD2 and its metabolite 15d-PGJ2 attenuate SCC proliferation in a PPARgamma-dependent manner, therefore activation of PPARgamma by agonists such as pioglitazone may benefit those at high risk of SCC. Prostaglandin D2 24-28 peroxisome proliferator activated receptor gamma Mus musculus 90-99 24917395-11 2014 This work suggests that PGD2 and its metabolite 15d-PGJ2 attenuate SCC proliferation in a PPARgamma-dependent manner, therefore activation of PPARgamma by agonists such as pioglitazone may benefit those at high risk of SCC. Prostaglandin D2 24-28 peroxisome proliferator activated receptor gamma Mus musculus 142-151 18628687-2 2008 Recent evidence also suggests that the cyclopentenone prostaglandin 15-deoxy-DeltaPGJ2 (15d-PGJ2), which is a metabolite of the prostaglandin D2, functions as an endogenous ligand for PPAR-gamma We postulated that 15d-PGJ2 would attenuate inflammation, investigating the effects on the degree of experimental spinal cord trauma induced by the application of vascular clips (force of 24 g) to the dura via a four-level T5-T8 laminectomy. Prostaglandin D2 128-144 peroxisome proliferator activated receptor gamma Mus musculus 184-194 24101662-8 2014 PGD(2) acted through its metabolite 15-deoxy-Delta12,14-PGJ(2) in the heart as evidenced by the glucocorticoid-mediated activation of peroxisome proliferator-activated receptor-gamma. Prostaglandin D2 0-6 peroxisome proliferator activated receptor gamma Mus musculus 134-182 24101662-11 2014 In addition, we propose activation of peroxisome proliferator-activated receptor-gamma by the dehydrated metabolite of PGD(2) (15-deoxy-Delta12,14-PGJ(2)) as another mechanism by which glucocorticoids induce cardioprotection. Prostaglandin D2 119-125 peroxisome proliferator activated receptor gamma Mus musculus 38-86 12543809-5 2003 However, PGD2 is chemically unstable, being converted first to PGJ2 and then stepwise to 15-deoxy-Delta(12,14)-prostaglandin J2(15Delta-PGJ2), a natural ligand for the peroxisome proliferator-activated receptor-gamma (PPARgamma). Prostaglandin D2 9-13 peroxisome proliferator activated receptor gamma Mus musculus 168-216 17239574-7 2007 PGD2 and its degradation products are known to mediate their anti-inflammatory effects by binding to peroxisome proliferators-activated receptor gamma (PPARgamma). Prostaglandin D2 0-4 peroxisome proliferator activated receptor gamma Mus musculus 101-150 17239574-7 2007 PGD2 and its degradation products are known to mediate their anti-inflammatory effects by binding to peroxisome proliferators-activated receptor gamma (PPARgamma). Prostaglandin D2 0-4 peroxisome proliferator activated receptor gamma Mus musculus 152-161 17239574-8 2007 In this study, we show that PPARgamma is upregulated during the resolution phase of wound repair concomitant with the shift to PGD2, and may be responsible for initiating endogenous mechanism resulting in healing/resolution. Prostaglandin D2 127-131 peroxisome proliferator activated receptor gamma Mus musculus 28-37 12573447-0 2003 Novel prostaglandin D(2)-derived activators of peroxisome proliferator-activated receptor-gamma are formed in macrophage cell cultures. Prostaglandin D2 6-24 peroxisome proliferator activated receptor gamma Mus musculus 47-95 15556157-6 2004 The order of the inhibitory activities of these prostaglandin D2 metabolites depended on affinity of the prostanoid DP1 receptor but not on the DP2 receptor (chemoattractant receptor-homologous molecule expressed on T helper2 cells, CRTH2) and PPAR-gamma receptors. Prostaglandin D2 48-64 peroxisome proliferator activated receptor gamma Mus musculus 244-254 12826907-1 2003 INTRODUCTION: The prostaglandin D2 metabolite, 15d-PGJ2, a potent natural ligand for peroxisome proliferator-activated receptor gamma (PPARgamma), exerts antiinflammatory effects by inhibiting the induction of inflammatory response genes and NF-kappaB-dependent transcription. Prostaglandin D2 18-34 peroxisome proliferator activated receptor gamma Mus musculus 85-133 12826907-1 2003 INTRODUCTION: The prostaglandin D2 metabolite, 15d-PGJ2, a potent natural ligand for peroxisome proliferator-activated receptor gamma (PPARgamma), exerts antiinflammatory effects by inhibiting the induction of inflammatory response genes and NF-kappaB-dependent transcription. Prostaglandin D2 18-34 peroxisome proliferator activated receptor gamma Mus musculus 135-144 12543809-5 2003 However, PGD2 is chemically unstable, being converted first to PGJ2 and then stepwise to 15-deoxy-Delta(12,14)-prostaglandin J2(15Delta-PGJ2), a natural ligand for the peroxisome proliferator-activated receptor-gamma (PPARgamma). Prostaglandin D2 9-13 peroxisome proliferator activated receptor gamma Mus musculus 218-227 10818446-4 2000 PGD2 undergoes dehydration to the biologically active prostaglandin 15-deoxy-delta 12,14-PGJ2 (15d-PGJ2) that binds to the nuclear receptor known as peroxisome proliferator-activated receptor gamma (PPAR-gamma). Prostaglandin D2 0-4 peroxisome proliferator activated receptor gamma Mus musculus 149-197 10818446-4 2000 PGD2 undergoes dehydration to the biologically active prostaglandin 15-deoxy-delta 12,14-PGJ2 (15d-PGJ2) that binds to the nuclear receptor known as peroxisome proliferator-activated receptor gamma (PPAR-gamma). Prostaglandin D2 0-4 peroxisome proliferator activated receptor gamma Mus musculus 199-209 33220278-4 2021 The cyclooxygenase (COX) cascade synthesizes prostaglandins (PGs) and plays a key role in inflammation, but is known to also have anti-inflammatory properties through an alternative route of a PGD2 metabolite, 15-deoxy-delta-12,14-prostaglandin J2 (15d-PGJ2), and its receptor, peroxisome proliferator-activated receptor gamma (PPARgamma). Prostaglandin D2 193-197 peroxisome proliferator activated receptor gamma Mus musculus 278-326 33220278-4 2021 The cyclooxygenase (COX) cascade synthesizes prostaglandins (PGs) and plays a key role in inflammation, but is known to also have anti-inflammatory properties through an alternative route of a PGD2 metabolite, 15-deoxy-delta-12,14-prostaglandin J2 (15d-PGJ2), and its receptor, peroxisome proliferator-activated receptor gamma (PPARgamma). Prostaglandin D2 193-197 peroxisome proliferator activated receptor gamma Mus musculus 328-337