PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8114674-5 1994 The major prostanoid products formed by microsomes from COS-7 cells containing either recombinant hPGHS-1 or hPGHS-2 after incubation with arachidonic acid were prostaglandin D2 and E2, with lower levels of prostaglandin F2 alpha and 6-keto-prostaglandin F1 alpha. Prostaglandin D2 161-177 prostaglandin-endoperoxide synthase 1 Homo sapiens 98-105 21392725-2 2011 These side effects have been attributed to release of the vasodilating prostaglandin D2, generated in a reaction catalyzed by cyclooxygenase-1. Prostaglandin D2 71-87 prostaglandin-endoperoxide synthase 1 Homo sapiens 126-142 11298331-5 2001 In addition, among the peptides examined, only hBD-2 significantly induced PGD(2) production, which was abolished by indomethacin (cyclooxygenase-1/-2 inhibitor) but not NS-398 (cyclooxygenase-2 inhibitor), suggesting that hBD-2-induced PGD(2) production is mediated by cyclooxygenase-1. Prostaglandin D2 75-81 prostaglandin-endoperoxide synthase 1 Homo sapiens 131-150 11298331-5 2001 In addition, among the peptides examined, only hBD-2 significantly induced PGD(2) production, which was abolished by indomethacin (cyclooxygenase-1/-2 inhibitor) but not NS-398 (cyclooxygenase-2 inhibitor), suggesting that hBD-2-induced PGD(2) production is mediated by cyclooxygenase-1. Prostaglandin D2 75-81 prostaglandin-endoperoxide synthase 1 Homo sapiens 131-147 9836494-14 1998 Prostaglandin D2 production appeared to be variably produced by cyclooxygenase-1 or cyclooxygenase-2, depending on the stimulus. Prostaglandin D2 0-16 prostaglandin-endoperoxide synthase 1 Homo sapiens 64-80