PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18006877-7	2008	Acrolein increased hMMP9 transcripts in human airway cells, which was inhibited by an MMP inhibitor, EGFR-neutralizing antibody, or a mitogen-activated protein kinase (MAPK) 3/2 inhibitor.	Acrolein	0-8	epidermal growth factor receptor	Homo sapiens	101-105	
11329622-0	2001	Acrolein induces activation of the epidermal growth factor receptor of human keratinocytes for cell death.	Acrolein	0-8	epidermal growth factor receptor	Homo sapiens	35-67	
15531749-9	2005	Together, these data suggest that acrolein induces MUC5AC expression via an initial ligand-dependent activation of EGFR mediated by ADAM17 and MMP9.	Acrolein	34-42	epidermal growth factor receptor	Homo sapiens	115-119	
11329622-3	2001	Incubation of human keratinocytes with a relatively low concentration (50 microM) of acrolein caused a prompt and selective induction of tyrosine phosphorylation of the epidermal growth factor receptor (EGFR) as a 180-kDa molecule during the period from 5-30 min after the start of incubation.	Acrolein	85-93	epidermal growth factor receptor	Homo sapiens	169-201	
11329622-3	2001	Incubation of human keratinocytes with a relatively low concentration (50 microM) of acrolein caused a prompt and selective induction of tyrosine phosphorylation of the epidermal growth factor receptor (EGFR) as a 180-kDa molecule during the period from 5-30 min after the start of incubation.	Acrolein	85-93	epidermal growth factor receptor	Homo sapiens	203-207	
11329622-7	2001	Selective prompt phosphorylation/activation of EGFR followed by phosphorylation of MAP family kinases and c-Jun and their blockade by a specific EGFR inhibitor, AG1478, suggested that activation of EGFR is the major, and possibly single, cell surface element for intracellular signal transduction in acrolein-treated cells.	Acrolein	300-308	epidermal growth factor receptor	Homo sapiens	47-51	
11329622-7	2001	Selective prompt phosphorylation/activation of EGFR followed by phosphorylation of MAP family kinases and c-Jun and their blockade by a specific EGFR inhibitor, AG1478, suggested that activation of EGFR is the major, and possibly single, cell surface element for intracellular signal transduction in acrolein-treated cells.	Acrolein	300-308	epidermal growth factor receptor	Homo sapiens	145-149	
11329622-7	2001	Selective prompt phosphorylation/activation of EGFR followed by phosphorylation of MAP family kinases and c-Jun and their blockade by a specific EGFR inhibitor, AG1478, suggested that activation of EGFR is the major, and possibly single, cell surface element for intracellular signal transduction in acrolein-treated cells.	Acrolein	300-308	epidermal growth factor receptor	Homo sapiens	145-149	
34298758-0	2021	Cigarette Smoke Containing Acrolein Upregulates EGFR Signaling Contributing to Oral Tumorigenesis In Vitro and In Vivo.	Acrolein	27-35	epidermal growth factor receptor	Homo sapiens	48-52	
34298758-11	2021	Furthermore, by examining tissue sample from patients, we found an increased EGFR copy number was positively associated with acrolein-induced DNA damages in OSCC patients.	Acrolein	125-133	epidermal growth factor receptor	Homo sapiens	77-81	
34298758-12	2021	Taken together, our results indicate that acrolein is important in tumorigenic transformation through amplification of EGFR and activating the downstream signaling pathway, contributing to oral carcinogenesis.	Acrolein	42-50	epidermal growth factor receptor	Homo sapiens	119-123	
34298758-13	2021	This is the first study to provide molecular evidence showing that CS containing acrolein contributes to EGFR amplification in OSCC.	Acrolein	81-89	epidermal growth factor receptor	Homo sapiens	105-109