PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23026831-7	2012	Acrolein exposure rapidly and dramatically decreased intracellular glutathione and overall antioxidant capacity, and activated the stress-signaling MAP-kinases JNK, p42/44 and p38.	Acrolein	0-8	mitogen-activated protein kinase 14	Homo sapiens	176-179	
24024160-6	2013	Acrolein exposure of HBE1 cells induced dose-dependent activation of the MAP kinases, extracellular regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38, and activation of JNK was markedly enhanced after selenite-mediated induction of TrxR1, and was associated with increased alkylation of TrxR1.	Acrolein	0-8	mitogen-activated protein kinase 14	Homo sapiens	159-162	
21812108-7	2011	ASK1 promotes MAP kinase activation, and p38 activation contributes to apoptosis and a number of other acrolein-induced stress responses.	Acrolein	103-111	mitogen-activated protein kinase 14	Homo sapiens	41-44	
23792774-10	2013	Inhibition of p38 MAPK by SB203580 abolished acrolein-induced muscle catabolism.	Acrolein	45-53	mitogen-activated protein kinase 14	Homo sapiens	14-17	
24558308-0	2014	Korean Red Ginseng water extract inhibits COX-2 expression by suppressing p38 in acrolein-treated human endothelial cells.	Acrolein	81-89	mitogen-activated protein kinase 14	Homo sapiens	74-77	
24558308-5	2014	Acrolein-induced COX-2 expression was accompanied by increased levels of phosphorylated p38 in HUVECs and KRG inhibited COX-2 expression in HUVECs.	Acrolein	0-8	mitogen-activated protein kinase 14	Homo sapiens	88-91	
24558308-6	2014	These results suggest that KRG suppresses acrolein-induced COX-2 expression via inhibition of the p38 mitogen-activated protein kinase signaling pathway.	Acrolein	42-50	mitogen-activated protein kinase 14	Homo sapiens	98-101	
23792774-9	2013	However, exposure to acrolein caused increased generation of free radicals, activation of p38 MAPK, upregulation of the muscle-specific E3 ligases atrogin-1 and MuRF1, degradation of myosin heavy chain, and atrophy of myotubes.	Acrolein	21-29	mitogen-activated protein kinase 14	Homo sapiens	90-93