PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9884322-0	1999	Inhibition of human aldehyde dehydrogenase 1 by the 4-hydroxycyclophosphamide degradation product acrolein.	Acrolein	98-106	aldehyde dehydrogenase 1 family member A1	Homo sapiens	20-44	
9884322-8	1999	The percentage of inhibition of ALDH1 activity in vivo by acrolein in patients receiving CY was calculated based on the in vitro Ki of acrolein, the in vitro Km of HCY, and the in vivo peak blood concentrations of HCY and acrolein.	Acrolein	135-143	aldehyde dehydrogenase 1 family member A1	Homo sapiens	32-37	
22339434-2	2012	In this work, it was determined that, among the three most studied human ALDH isoforms, ALDH2 showed the highest catalytic efficiency for oxidation of acrolein, 4-hydroxy-2-nonenal (4-HNE), and malondialdehyde.	Acrolein	151-159	aldehyde dehydrogenase 1 family member A1	Homo sapiens	73-77	
22339434-6	2012	Formation of adducts of ALDH1A1 and ALDH2 with acrolein increased their K(d) values for NAD(+) by 2- and 3-fold, respectively.	Acrolein	47-55	aldehyde dehydrogenase 1 family member A1	Homo sapiens	24-31	
9884322-4	1999	In human liver cytosol incubations, HCY inhibited ALDH activity mainly through its degradation product acrolein, whereas carboxyethylphosphoramide mustard inhibited ALDH activity only at supraclinical concentrations.	Acrolein	103-111	aldehyde dehydrogenase 1 family member A1	Homo sapiens	50-54	
9884322-6	1999	The inhibition of ALDH1 activity by acrolein in incubations with human erythrocyte ALDH1 was competitive with a Ki of 0.646 microM.	Acrolein	36-44	aldehyde dehydrogenase 1 family member A1	Homo sapiens	18-23	
9884322-6	1999	The inhibition of ALDH1 activity by acrolein in incubations with human erythrocyte ALDH1 was competitive with a Ki of 0.646 microM.	Acrolein	36-44	aldehyde dehydrogenase 1 family member A1	Homo sapiens	83-88	
9884322-8	1999	The percentage of inhibition of ALDH1 activity in vivo by acrolein in patients receiving CY was calculated based on the in vitro Ki of acrolein, the in vitro Km of HCY, and the in vivo peak blood concentrations of HCY and acrolein.	Acrolein	58-66	aldehyde dehydrogenase 1 family member A1	Homo sapiens	32-37	
9884322-8	1999	The percentage of inhibition of ALDH1 activity in vivo by acrolein in patients receiving CY was calculated based on the in vitro Ki of acrolein, the in vitro Km of HCY, and the in vivo peak blood concentrations of HCY and acrolein.	Acrolein	135-143	aldehyde dehydrogenase 1 family member A1	Homo sapiens	32-37	
9698086-5	1998	We found that both ALDH isozymes were inhibited by acrolein, with IC50 values of 35 and 144 microM for ALDH-1 or ALDH-3, respectively.	Acrolein	51-59	aldehyde dehydrogenase 1 family member A1	Homo sapiens	103-109	
9698086-7	1998	In contrast, thiol conjugates of acrolein did not inhibit ALDH-3 activity, but were substrates only for ALDH-1.	Acrolein	33-41	aldehyde dehydrogenase 1 family member A1	Homo sapiens	104-110