PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16195596-2 2005 Acrolein-modified apoE in VLDL was not taken up by human hepatoma cell whereas unmodified apoE in the presence of ascorbate was taken up. Acrolein 0-8 apolipoprotein E Homo sapiens 18-22 17580963-0 2007 Modification by acrolein, a component of tobacco smoke and age-related oxidative stress, mediates functional impairment of human apolipoprotein E. Acrolein 16-24 apolipoprotein E Homo sapiens 129-145 17580963-5 2007 We investigated the effect of acrolein, an aldehydic product of endogenous lipid peroxidation and a tobacco smoke component, on the conformation and function of recombinant human apoE3-NT. Acrolein 30-38 apolipoprotein E Homo sapiens 179-184 17580963-6 2007 Acrolein caused oxidative modification of apoE3-NT as detected by Western blot with acrolein-lysine-specific antibodies, and tertiary conformational alterations. Acrolein 0-8 apolipoprotein E Homo sapiens 42-47 17580963-7 2007 Acrolein modification impairs the ability of apoE3-NT to interact with heparin and the LDL receptor. Acrolein 0-8 apolipoprotein E Homo sapiens 45-50 16195596-2 2005 Acrolein-modified apoE in VLDL was not taken up by human hepatoma cell whereas unmodified apoE in the presence of ascorbate was taken up. Acrolein 0-8 apolipoprotein E Homo sapiens 90-94