PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32526913-1 2020 The Transient Receptor Potential Ankyrin 1 (TRPA1) cation channel expressed on capsaicin-sensitive afferents, immune and endothelial cells is activated by inflammatory mediators and exogenous irritants, e.g., endotoxins, nicotine, crotonaldehyde and acrolein. Acrolein 250-258 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 4-42 32526913-1 2020 The Transient Receptor Potential Ankyrin 1 (TRPA1) cation channel expressed on capsaicin-sensitive afferents, immune and endothelial cells is activated by inflammatory mediators and exogenous irritants, e.g., endotoxins, nicotine, crotonaldehyde and acrolein. Acrolein 250-258 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 44-49 29627347-2 2018 We previously showed that a single exposure to acrolein, a ubiquitous gaseous component of air pollution, not only causes autonomic imbalance, but also increases arrhythmia through transient receptor potential A1 (TRPA1) cation channels. Acrolein 47-55 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 181-212 30735434-2 2019 The transient receptor potential ankyrin 1 (TRPA1) mediates pain signaling and is activated by unsaturated aldehydes, including acrolein and 4-hydroxynonenal. Acrolein 128-136 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 4-42 30735434-2 2019 The transient receptor potential ankyrin 1 (TRPA1) mediates pain signaling and is activated by unsaturated aldehydes, including acrolein and 4-hydroxynonenal. Acrolein 128-136 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 44-49 30735434-8 2019 A role of TRPA1 in cardiomyocyte toxicity was demonstrated in isolated cardiomyocytes exposed to acrolein, an I/R-associated toxin that induces Ca2+ accumulation and hypercontraction, effects significantly blunted by HC-030031, a TRPA1 antagonist. Acrolein 97-105 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 10-15 30735434-8 2019 A role of TRPA1 in cardiomyocyte toxicity was demonstrated in isolated cardiomyocytes exposed to acrolein, an I/R-associated toxin that induces Ca2+ accumulation and hypercontraction, effects significantly blunted by HC-030031, a TRPA1 antagonist. Acrolein 97-105 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 230-235 30735434-13 2019 Functional TRPA1 in cardiomyocytes was enriched in intercalated disks and contributed to acrolein-induced Ca2+ overload and hypercontraction. Acrolein 89-97 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 11-16 30351402-0 2019 Ambient Particulate Matter and Acrolein Co-Exposure Increases Myocardial Dyssynchrony in Mice via TRPA1. Acrolein 31-39 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 98-103 29627347-2 2018 We previously showed that a single exposure to acrolein, a ubiquitous gaseous component of air pollution, not only causes autonomic imbalance, but also increases arrhythmia through transient receptor potential A1 (TRPA1) cation channels. Acrolein 47-55 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 214-219 29627347-3 2018 Thus, the goal of this study was to characterize acrolein-induced autonomic changes in both normal and TRPA1-knockout mice (KO). Acrolein 49-57 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 103-108 27592100-0 2017 Role of TRPA1 in acute cardiopulmonary toxicity of inhaled acrolein. Acrolein 59-67 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 8-13 27746315-13 2017 These data demonstrate that a single exposure to acrolein causes cardiac dysfunction through TRPA1 activation and autonomic imbalance characterized by a shift toward parasympathetic modulation. Acrolein 49-57 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 93-98 27592100-2 2017 Because the transient receptor potential ankyrin 1 (TRPA1) channel mediates tobacco smoke-induced lung injury, we assessed its role in high-level acrolein-induced toxicity in mice. Acrolein 146-154 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 52-57 27592100-5 2017 Both male and female TRPA1-null mice were more sensitive to acrolein-induced mortality than age- and sex-matched WT mice. Acrolein 60-68 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 21-26 27592100-6 2017 Acrolein exposure increased lung weight:body weight ratios and lung albumin and decreased plasma albumin to a greater extent in TRPA1-null than in WT mice. Acrolein 0-8 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 128-133 27592100-11 2017 These data show TRPA1 protects against high-level acrolein-induced toxicity in a sex-dependent manner. Acrolein 50-58 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 16-21 27592100-12 2017 Post-exposure TRPA1 antagonism also protected against acrolein-induced mortality attesting to a complex role of TRPA1 in cardiopulmonary injury. Acrolein 54-62 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 14-19 27592100-12 2017 Post-exposure TRPA1 antagonism also protected against acrolein-induced mortality attesting to a complex role of TRPA1 in cardiopulmonary injury. Acrolein 54-62 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 112-117 27746315-0 2017 TRPA1 mediates changes in heart rate variability and cardiac mechanical function in mice exposed to acrolein. Acrolein 100-108 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 0-5 27746315-4 2017 Thus, this study examines the role of TRPA1, an irritant sensory receptor found in the airways, in the cardiac response of mice to acrolein and ozone. Acrolein 131-139 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 38-43 24561178-12 2014 Pharmacologic studies indicate that acrolein-induced relaxation likely involves interplay between TRPA1-expressing airway sensory C-fibres, NK1 receptor-expressing epithelial cells, and EP2-receptor expressing airway smooth muscle cells. Acrolein 36-44 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 98-103 26472811-6 2015 In contrast, the gas phase acted like a sheer TRPA1 agonist, consistent with its composition, among other compounds, of volatile reactive carbonyls like formaldehyde and acrolein. Acrolein 170-178 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 46-51 24561178-0 2014 Acrolein relaxes mouse isolated tracheal smooth muscle via a TRPA1-dependent mechanism. Acrolein 0-8 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 61-66 24561178-2 2014 TRPA1 likely plays an intermediary role in eliciting a range of effects induced by acrolein including cough and neurogenic inflammation. Acrolein 83-91 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 0-5 24561178-3 2014 Currently, it is not known whether acrolein-induced activation of TRPA1 produces other airway effects including relaxation of mouse airway smooth muscle. Acrolein 35-43 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 66-71 24172941-3 2013 Using behavioral testing, we found that TRPA1 knockout mice failed to avoid entering a chamber filled with vapor of formalin, allyl isothiocyanate, and acrolein. Acrolein 152-160 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 40-45 21903934-5 2011 Menthol, at a concentration (16 ppm) lower than in smoke of mentholated cigarettes, immediately abolished the irritation response to acrolein, an agonist of TRPA1, as did eucalyptol (460 ppm), another TRPM8 agonist. Acrolein 133-141 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 157-162 19371406-6 2009 RESULTS: Morphine induced release of calcitonin gene-related peptide and sensitized the release evoked by heat or the TRPA1 agonist acrolein. Acrolein 132-140 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 118-123 18322093-1 2008 Transient receptor potential A1 (TRPA1) is expressed in a subset of nociceptive sensory neurons where it acts as a sensor for environmental irritants, including acrolein, and some pungent plant ingredients such as allyl isothiocyanate and cinnamaldehyde. Acrolein 161-169 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 33-38 16564016-4 2006 TRPA1 is also targeted by environmental irritants, such as acrolein, that account for toxic and inflammatory actions of tear gas, vehicle exhaust, and metabolic byproducts of chemotherapeutic agents. Acrolein 59-67 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 0-5 34271065-0 2021 Acrolein but not its metabolite, 3-Hydroxypropylmercapturic acid (3HPMA), activates vascular transient receptor potential Ankyrin-1 (TRPA1): Physiological to toxicological implications. Acrolein 0-8 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 93-131 34271065-0 2021 Acrolein but not its metabolite, 3-Hydroxypropylmercapturic acid (3HPMA), activates vascular transient receptor potential Ankyrin-1 (TRPA1): Physiological to toxicological implications. Acrolein 0-8 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 133-138 34271065-3 2021 The hypothesis of this study is the direct effects of acrolein in isolated murine blood vessels (aorta and superior mesenteric artery, SMA) are transient receptor potential ankyrin-1 (TRPA1) dependent. Acrolein 54-62 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 144-182 34271065-3 2021 The hypothesis of this study is the direct effects of acrolein in isolated murine blood vessels (aorta and superior mesenteric artery, SMA) are transient receptor potential ankyrin-1 (TRPA1) dependent. Acrolein 54-62 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 184-189 34271065-8 2021 The potency of acrolein-induced relaxation was inhibited significantly by: 1) mechanically-impaired endothelium; 2) Nomega-Nitro-L-arginine methyl ester hydrochloride (L-NAME); 3) guanylyl cyclase (GC) inhibitor (ODQ); and, 4) a TRPA1 antagonist (A967079). Acrolein 15-23 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 229-234 34271065-10 2021 Compared with other known TRPA1 agonists, including allyl isothiocyanate (AITC), cinnamaldehyde, crotonaldehyde, and formaldehyde, acrolein stimulated a more potent TRPA1-dependent relaxation. Acrolein 131-139 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 26-31 34271065-10 2021 Compared with other known TRPA1 agonists, including allyl isothiocyanate (AITC), cinnamaldehyde, crotonaldehyde, and formaldehyde, acrolein stimulated a more potent TRPA1-dependent relaxation. Acrolein 131-139 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 165-170 21868092-8 2011 Acrolein and mustard oil (MO)--at muM concentrations--induced a TRPA1-dependent iCGRP release; however, millimolar concentrations of mustard oil (>1mM) evoked iCGRP release by activating TRPV1, confirming recent evidence for TRPV1 agonism of high mustard oil concentrations. Acrolein 0-8 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 64-69 20601631-7 2010 TRPA1, a TRP ion channel expressed in chemosensory C-fibers, is activated by almost all oxidizing and electrophilic chemicals, including chlorine, acrolein, tear gas agents, and methyl isocyanate, the highly noxious chemical released in the Bhopal disaster. Acrolein 147-155 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 0-5