PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
2501305-0	1989	Chemical modification of carbonic anhydrase II with acrolein.	Acrolein	52-60	carbonic anhydrase 2	Homo sapiens	25-46	
2501305-1	1989	We have reacted acrolein with human carbonic anhydrase II using conditions reported to result in maximal formylethylation of exposed histidine and lysine residues (Pocker, Y., and Janjic, N. (1988) J. Biol.	Acrolein	16-24	carbonic anhydrase 2	Homo sapiens	36-57	
2501305-7	1989	The 18O-exchange kinetics catalyzed by the acrolein-modified carbonic anhydrase II was similar to that catalyzed by a mutant human carbonic anhydrase II in which histidine at residue 64 was replaced with alanine.	Acrolein	43-51	carbonic anhydrase 2	Homo sapiens	61-82	
2501305-7	1989	The 18O-exchange kinetics catalyzed by the acrolein-modified carbonic anhydrase II was similar to that catalyzed by a mutant human carbonic anhydrase II in which histidine at residue 64 was replaced with alanine.	Acrolein	43-51	carbonic anhydrase 2	Homo sapiens	131-152	
2501305-8	1989	Moreover, modification of this mutant carbonic anhydrase II with acrolein did not alter to a significant extent its 18O-exchange pattern.	Acrolein	65-73	carbonic anhydrase 2	Homo sapiens	38-59	
3129421-1	1988	Incubation of carbonic anhydrase II with acrolein results in a rapid, time-dependent loss of all but approximately 3-6% of the original catalytic activity toward CO2 hydration and HCO3- dehydration, with the inactivation rate being first-order in both acrolein and the enzyme.	Acrolein	41-49	carbonic anhydrase 2	Homo sapiens	14-35	
3129421-1	1988	Incubation of carbonic anhydrase II with acrolein results in a rapid, time-dependent loss of all but approximately 3-6% of the original catalytic activity toward CO2 hydration and HCO3- dehydration, with the inactivation rate being first-order in both acrolein and the enzyme.	Acrolein	252-260	carbonic anhydrase 2	Homo sapiens	14-35	
3129421-3	1988	The amount of residual CO2 hydratase activity is proportional to the molar excess of acrolein over carbonic anhydrase II with 5 histidyl and 3 lysyl residues being subject to alkylation under conditions where [acrolein] to [carbonic anhydrase II] ratio is greater than 100.	Acrolein	85-93	carbonic anhydrase 2	Homo sapiens	224-245