PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23770200-8	2013	Further, fidarestat inhibited acrolein-induced translocation of the proapoptotic proteins Bax and Bad from the cytosol to the mitochondria and that of Bcl2 and BclXL from the mitochondria to the cytosol.	Acrolein	30-38	BCL2 apoptosis regulator	Homo sapiens	151-155	
24376112-8	2015	However, the acrolein-induced cardiomyocyte contractile and intracellular Ca(2+) anomalies, as well as apoptosis (as evidenced by Bcl-2, Bax, FasL, Caspase-3 and -8), were negated by the reactive oxygen species (ROS) scavenger glutathione or the TRPV1 antagonist capsazepine.	Acrolein	13-21	BCL2 apoptosis regulator	Homo sapiens	130-135	
31864078-6	2020	Acrolein exposure reduced survival rate of VSMCs, and raised apoptosis percentage through upregulating the expression of Bax, Cytochrome c and Cleaved caspase-3 and downregulating Bcl-2.	Acrolein	0-8	BCL2 apoptosis regulator	Homo sapiens	180-185	
21854768-0	2011	Acrolein sensitizes human renal cancer Caki cells to TRAIL-induced apoptosis via ROS-mediated up-regulation of death receptor-5 (DR5) and down-regulation of Bcl-2.	Acrolein	0-8	BCL2 apoptosis regulator	Homo sapiens	157-162	
21854768-6	2011	We found that acrolein down-regulated the protein level of Bcl-2 and Bcl-2 overexpression inhibited the cell death induced by the combined treatment with acrolein and TRAIL.	Acrolein	14-22	BCL2 apoptosis regulator	Homo sapiens	59-64	
21854768-6	2011	We found that acrolein down-regulated the protein level of Bcl-2 and Bcl-2 overexpression inhibited the cell death induced by the combined treatment with acrolein and TRAIL.	Acrolein	14-22	BCL2 apoptosis regulator	Homo sapiens	69-74	
21854768-9	2011	Taken together, our results demonstrated that acrolein enhances TRAIL-induced apoptosis in Caki cells through down-regulation of Bcl-2 and ROS dependent up-regulation of DR5.	Acrolein	46-54	BCL2 apoptosis regulator	Homo sapiens	129-134