PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12487375-6	2002	Furthermore, exposure to acrolein results in activation of members of the mitogen-activated protein kinase (MAPK) family and protein tyrosine kinases.	Acrolein	25-33	mitogen activated protein kinase 3	Rattus norvegicus	108-112	
12487375-7	2002	The extracellular signal-regulated kinases 1 and 2 (ERK1/2), stress-activated protein kinases/c-jun NH2-terminal kinases (SAPK/JNK) and p38MAPK are effectively and transiently activated by acrolein in a concentration and time-dependent fashion.	Acrolein	189-197	mitogen activated protein kinase 3	Rattus norvegicus	4-50	
12487375-7	2002	The extracellular signal-regulated kinases 1 and 2 (ERK1/2), stress-activated protein kinases/c-jun NH2-terminal kinases (SAPK/JNK) and p38MAPK are effectively and transiently activated by acrolein in a concentration and time-dependent fashion.	Acrolein	189-197	mitogen activated protein kinase 3	Rattus norvegicus	52-58	
12487375-8	2002	While all three MAPKs exhibit significant activation within 5 min of exposure to acrolein, maximum activation (ERK1/2 and p38MAPK) or close to maximum activation (SAPK/JNK) occurs on exposure to 5 microg/ml acrolein for 2 h. Acrolein-induced activation of MAPKs is further substantiated by the activation of transcription factors, c-jun and activator transcription factor-2 (ATF-2), by acrolein-activated SAPK/JNK and p38MAPK, respectively.	Acrolein	207-215	mitogen activated protein kinase 3	Rattus norvegicus	111-117	
12487375-16	2002	These results provide the first evidence that the activation of both growth-regulated (ERK1/2) and stress-regulated (SAPK/JNK and p38MAPK) MAPKs as well as tyrosine kinases are involved in the mediation of acrolein-induced effects on VSMC, which may play a crucial role in vascular pathogenesis due to environmentally and endogenously produced acrolein.	Acrolein	206-214	mitogen activated protein kinase 3	Rattus norvegicus	87-93	
12487375-16	2002	These results provide the first evidence that the activation of both growth-regulated (ERK1/2) and stress-regulated (SAPK/JNK and p38MAPK) MAPKs as well as tyrosine kinases are involved in the mediation of acrolein-induced effects on VSMC, which may play a crucial role in vascular pathogenesis due to environmentally and endogenously produced acrolein.	Acrolein	344-352	mitogen activated protein kinase 3	Rattus norvegicus	87-93	
21422526-10	2011	Acrolein also induced the phosphorylation of p66shc and of ERK1/2 after 30 min of treatment.	Acrolein	0-8	mitogen activated protein kinase 3	Rattus norvegicus	59-65