PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31639409-4	2020	It was found that acrolein increased the levels of NLRP3 and cleaved caspase-1, which led to the maturation of interleukin-1beta (IL-1beta).	Acrolein	18-26	NLR family pyrin domain containing 3	Homo sapiens	51-56	
31639409-8	2020	Furthermore, we found that acrolein activated p38 MAPK and NF-kappaB p65, while pretreatment with p38 MAPK inhibitor, SB203580 and GI 254023X inhibited NF-kappaB p65 activation and NLRP3 inflammasome.	Acrolein	27-35	NLR family pyrin domain containing 3	Homo sapiens	181-186	
31639409-11	2020	In conclusion, we demonstrate that acrolein induces astrocytic inflammation through NLRP3 inflammasome, which is regulated by ADAM10 and attributed to p38 MAPK-activated NF-kappaB p65 activity.	Acrolein	35-43	NLR family pyrin domain containing 3	Homo sapiens	84-89	
30205151-0	2018	Acrolein induces NLRP3 inflammasome-mediated pyroptosis and suppresses migration via ROS-dependent autophagy in vascular endothelial cells.	Acrolein	0-8	NLR family pyrin domain containing 3	Homo sapiens	17-22	
30205151-4	2018	In addition, exposure to acrolein resulted in NLRP3 inflammasome activation as evidenced by cleavage of caspase-1 and downstream mature interleukin (IL)-1beta and IL-18 secretion.	Acrolein	25-33	NLR family pyrin domain containing 3	Homo sapiens	46-51	
30205151-5	2018	Knockdown of NLRP3 by small interfering RNA remarkably suppressed acrolein-induced pyroptosis and increased cell migration.	Acrolein	66-74	NLR family pyrin domain containing 3	Homo sapiens	13-18	
30205151-9	2018	Besides, we found damaged mitochondrion accentuated NLRP3 inflammasome and pyroptosis in acrolein-treated cells.	Acrolein	89-97	NLR family pyrin domain containing 3	Homo sapiens	52-57	
34238121-4	2021	Additionally, acrolein induces EAhy926 cells inflammatory response and pyroptosis by activating NOD-like receptor protein 3 (NLRP3) inflammasome.	Acrolein	14-22	NLR family pyrin domain containing 3	Homo sapiens	96-123	
34238121-4	2021	Additionally, acrolein induces EAhy926 cells inflammatory response and pyroptosis by activating NOD-like receptor protein 3 (NLRP3) inflammasome.	Acrolein	14-22	NLR family pyrin domain containing 3	Homo sapiens	125-130	
34238121-7	2021	Notably, the present study also indicates that autophagy inhibited by inhibitor 3-methyladenine (3MA) and siAtg7 exacerbate acrolein-induced NLRP3 inflammasome activation and pyroptosis.	Acrolein	124-132	NLR family pyrin domain containing 3	Homo sapiens	141-146	
34238121-8	2021	In summary, acrolein induced cytotoxicity by ROS-mediated NLRP3 inflammasome activation, and ROS upregulates the level of autophagy to inhibit the NLRP3 inflammasome excessive activation, indicating the bidirectional role of ROS in acrolein-induced cellular inflammation.	Acrolein	12-20	NLR family pyrin domain containing 3	Homo sapiens	58-63	
34238121-8	2021	In summary, acrolein induced cytotoxicity by ROS-mediated NLRP3 inflammasome activation, and ROS upregulates the level of autophagy to inhibit the NLRP3 inflammasome excessive activation, indicating the bidirectional role of ROS in acrolein-induced cellular inflammation.	Acrolein	232-240	NLR family pyrin domain containing 3	Homo sapiens	147-152