PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8388709-1 1993 The allosteric modulation of the progesterone metabolite 3 alpha- hydroxy-5 alpha-pregnan-20-one (DHP) on [3H]Flunitrazepam and [35S]t-butylbicyclophosphorothionate (TBPS) binding was investigated on a soluble receptor preparation. Flunitrazepam 106-123 dihydropyrimidinase Homo sapiens 98-101 8388709-3 1993 We found that DHP was able to enhance [3H]Flunitrazepam binding in the presence of Cl- ions, while [35S]TBPS binding was inhibited by DHP. Flunitrazepam 42-55 dihydropyrimidinase Homo sapiens 14-17 8388709-4 1993 Scatchard analysis of specific [35S]TBPS and [3H]Flunitrazepam binding yielded in a single straight line both in the controls and in the presence of the hormone; DHP increased the apparent affinity of [3H]Flunitrazepam binding without altering the apparent Bmax value. Flunitrazepam 49-62 dihydropyrimidinase Homo sapiens 162-165