PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12640218-0	2003	The role of cytochrome P450 2C19 activity in flunitrazepam metabolism in vivo.	Flunitrazepam	45-58	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	12-32	
12640218-2	2003	In vitro studies have shown that the metabolism of flunitrazepam to desmethylflunitrazepam and 3-hydroxyflunitrazepam is mediated in part by the polymorphic enzyme CYP2C19.	Flunitrazepam	51-64	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	164-171	
12640218-3	2003	The objective was to examine the role of CYP2C19 activity in determining flunitrazepam kinetics in vivo.	Flunitrazepam	73-86	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	41-48	
12640218-8	2003	With increasing OMR (decreasing CYP2C19 activity), the ratio of flunitrazepam to both desmethylflunitrazepam and 3-hydroxyflunitrazepam AUCs increased ( r = 0.55, p = 0.03 and r = 0.65, p = 0.01, respectively).	Flunitrazepam	64-77	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	32-39	
12640218-10	2003	The authors conclude that CYP2C19 contributes to the metabolism of flunitrazepam to desmethylflunitrazepam and 3-hydroxyflunitrazepam in vivo, but these data suggest that its role is minor and that differences in CYP2C19 activity do not likely substantially influence its clinical effects.	Flunitrazepam	67-80	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	26-33	
12640218-10	2003	The authors conclude that CYP2C19 contributes to the metabolism of flunitrazepam to desmethylflunitrazepam and 3-hydroxyflunitrazepam in vivo, but these data suggest that its role is minor and that differences in CYP2C19 activity do not likely substantially influence its clinical effects.	Flunitrazepam	67-80	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	213-220	
11259331-1	2001	We have identified CYP2C19 and CYP3A4 as the principal cytochrome P450s involved in the metabolism of flunitrazepam to its major metabolites desmethylflunitrazepam and 3-hydroxyflunitrazepam.	Flunitrazepam	102-115	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	19-26	
11259331-8	2001	We estimate that the relative contributions of CYP2C19 and CYP3A4 to the formation of desmethylflunitrazepam in vivo are 63 and 37%, respectively, at therapeutic flunitrazepam concentrations (0.03 microM).	Flunitrazepam	95-108	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	47-54	
11259331-9	2001	We conclude that the polymorphic enzyme CYP2C19 importantly mediates flunitrazepam demethylation, which may alter the efficacy and safety of the drug, while CYP3A4 catalyzes the formation of 3-hydroxyflunitrazepam.	Flunitrazepam	69-82	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	40-47	
10911933-6	2000	Using in vitro studies, we have identified drugs of abuse that are substrates of the polymorphic enzymes CYP2D6 (codeine, amphetamines, dextromethorphan), CYP2A6 (nicotine) and CYP2C19 (flunitrazepam).	Flunitrazepam	186-199	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	177-184	
10574680-0	1999	Flunitrazepam oxidative metabolism in human liver microsomes: involvement of CYP2C19 and CYP3A4.	Flunitrazepam	0-13	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	77-84