PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12640218-0 2003 The role of cytochrome P450 2C19 activity in flunitrazepam metabolism in vivo. Flunitrazepam 45-58 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 12-32 12640218-2 2003 In vitro studies have shown that the metabolism of flunitrazepam to desmethylflunitrazepam and 3-hydroxyflunitrazepam is mediated in part by the polymorphic enzyme CYP2C19. Flunitrazepam 51-64 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 164-171 12640218-3 2003 The objective was to examine the role of CYP2C19 activity in determining flunitrazepam kinetics in vivo. Flunitrazepam 73-86 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 41-48 12640218-8 2003 With increasing OMR (decreasing CYP2C19 activity), the ratio of flunitrazepam to both desmethylflunitrazepam and 3-hydroxyflunitrazepam AUCs increased ( r = 0.55, p = 0.03 and r = 0.65, p = 0.01, respectively). Flunitrazepam 64-77 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 32-39 12640218-10 2003 The authors conclude that CYP2C19 contributes to the metabolism of flunitrazepam to desmethylflunitrazepam and 3-hydroxyflunitrazepam in vivo, but these data suggest that its role is minor and that differences in CYP2C19 activity do not likely substantially influence its clinical effects. Flunitrazepam 67-80 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 26-33 12640218-10 2003 The authors conclude that CYP2C19 contributes to the metabolism of flunitrazepam to desmethylflunitrazepam and 3-hydroxyflunitrazepam in vivo, but these data suggest that its role is minor and that differences in CYP2C19 activity do not likely substantially influence its clinical effects. Flunitrazepam 67-80 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 213-220 11259331-1 2001 We have identified CYP2C19 and CYP3A4 as the principal cytochrome P450s involved in the metabolism of flunitrazepam to its major metabolites desmethylflunitrazepam and 3-hydroxyflunitrazepam. Flunitrazepam 102-115 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 19-26 11259331-8 2001 We estimate that the relative contributions of CYP2C19 and CYP3A4 to the formation of desmethylflunitrazepam in vivo are 63 and 37%, respectively, at therapeutic flunitrazepam concentrations (0.03 microM). Flunitrazepam 95-108 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 47-54 11259331-9 2001 We conclude that the polymorphic enzyme CYP2C19 importantly mediates flunitrazepam demethylation, which may alter the efficacy and safety of the drug, while CYP3A4 catalyzes the formation of 3-hydroxyflunitrazepam. Flunitrazepam 69-82 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 40-47 10911933-6 2000 Using in vitro studies, we have identified drugs of abuse that are substrates of the polymorphic enzymes CYP2D6 (codeine, amphetamines, dextromethorphan), CYP2A6 (nicotine) and CYP2C19 (flunitrazepam). Flunitrazepam 186-199 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 177-184 10574680-0 1999 Flunitrazepam oxidative metabolism in human liver microsomes: involvement of CYP2C19 and CYP3A4. Flunitrazepam 0-13 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 77-84