PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11159802-0	2001	CYP3A4 is the major CYP isoform mediating the in vitro hydroxylation and demethylation of flunitrazepam.	Flunitrazepam	90-103	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	0-6	
19005028-5	2009	By exposure to 100 microM flunitrazepam, nimetazepam, or nitrazepam, the cell viability in the presence of CYP3A4 decreased more than 25% compared with that of the control.	Flunitrazepam	26-39	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	107-113	
19005028-7	2009	These results suggested that nitrobenzodiazepines such as flunitrazepam, nimetazepam, and nitrazepam were metabolically activated by CYP3A4, which resulted in cytotoxicity.	Flunitrazepam	58-71	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	133-139	
11259331-1	2001	We have identified CYP2C19 and CYP3A4 as the principal cytochrome P450s involved in the metabolism of flunitrazepam to its major metabolites desmethylflunitrazepam and 3-hydroxyflunitrazepam.	Flunitrazepam	102-115	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	31-37	
11259331-8	2001	We estimate that the relative contributions of CYP2C19 and CYP3A4 to the formation of desmethylflunitrazepam in vivo are 63 and 37%, respectively, at therapeutic flunitrazepam concentrations (0.03 microM).	Flunitrazepam	95-108	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	59-65	
10873929-8	2000	Projected in vivo inhibition of CYP3A4-mediated metabolism of flunitrazepam by buprenorphine is 0.	Flunitrazepam	62-75	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	32-38	
10574680-0	1999	Flunitrazepam oxidative metabolism in human liver microsomes: involvement of CYP2C19 and CYP3A4.	Flunitrazepam	0-13	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	89-95