PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1847384-4 1991 Flunitrazepam, a benzodiazepine which binds to MBR with high nanomolar affinity, inhibited the steroidogenic activity of these hormones, or the activation by 1 mM dibutyryl cAMP, in both cell lines by 30-60% with an IC50 of 500-1000 nM. Flunitrazepam 0-13 translocator protein Homo sapiens 47-50 1847384-5 1991 Scatchard analysis in both cell lines revealed one class of specific binding sites for [3H] flunitrazepam verified as being MBR by displacement studies with a series of MBR ligands. Flunitrazepam 92-105 translocator protein Homo sapiens 124-127 1847384-5 1991 Scatchard analysis in both cell lines revealed one class of specific binding sites for [3H] flunitrazepam verified as being MBR by displacement studies with a series of MBR ligands. Flunitrazepam 92-105 translocator protein Homo sapiens 169-172 1847384-6 1991 The potencies of these ligands to compete against the antagonism of hormone-stimulated steroidogenesis by flunitrazepam correlated significantly with their abilities to compete against [3H]flunitrazepam binding to MBR (r = 0.99). Flunitrazepam 106-119 translocator protein Homo sapiens 214-217 1847384-8 1991 These observations provide unequivocal evidence that the antagonistic action of flunitrazepam is mediated through its interaction with MBR demonstrating that these drug recognition sites are coupled to steroid biosynthesis activated by tropic hormones. Flunitrazepam 80-93 translocator protein Homo sapiens 135-138 24814875-6 2014 Ligation of TSPO (using PK11195, FGIN-1-27 and flunitrazepam) triggered increases in [3H]cholesterol efflux, an effect that was amplified in TSPO-overexpressing macrophages. Flunitrazepam 47-60 translocator protein Homo sapiens 12-16 24814875-6 2014 Ligation of TSPO (using PK11195, FGIN-1-27 and flunitrazepam) triggered increases in [3H]cholesterol efflux, an effect that was amplified in TSPO-overexpressing macrophages. Flunitrazepam 47-60 translocator protein Homo sapiens 141-145