PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
3761316-0	1986	Binding requirements of phenolic phenylethylamines in the benzonorbornene skeleton at the active site of phenylethanolamine N-methyltransferase.	Phenethylamines	33-50	phenylethanolamine N-methyltransferase	Homo sapiens	105-143	
3172133-1	1988	Phenylethylamines and phenylethanolamines represent two major classes of ligands for the epinephrine synthesizing enzyme, phenylethanolamine N-methyltransferase (PNMT;EC 2.1.1.28).	Phenethylamines	0-17	phenylethanolamine N-methyltransferase	Homo sapiens	122-160	
3172133-1	1988	Phenylethylamines and phenylethanolamines represent two major classes of ligands for the epinephrine synthesizing enzyme, phenylethanolamine N-methyltransferase (PNMT;EC 2.1.1.28).	Phenethylamines	0-17	phenylethanolamine N-methyltransferase	Homo sapiens	162-166	
2913308-2	1989	In addition, these analogues provided information about the effects of conformational flexibility on active-site interaction of the aminoethyl side chain in phenolic phenylethylamines that may aid in learning the manner in which norepinephrine binds at the active site of PNMT.	Phenethylamines	166-183	phenylethanolamine N-methyltransferase	Homo sapiens	272-276	
2913486-0	1989	Conformational and steric aspects of phenylethanolamine and phenylethylamine analogues as substrates or inhibitors of phenylethanolamine N-methyltransferase.	Phenethylamines	60-76	phenylethanolamine N-methyltransferase	Homo sapiens	118-156	
2913486-1	1989	The conformational and steric aspects of binding to phenylethanolamine N-methyltransferase (PNMT; EC 2.1.1.28) for phenylethanolamine substrates and phenylethylamine inhibitors were probed with three conformationally defined analogues (11, 12, and 13) of phenylethylamine (1) and phenylethanolamine (6) containing the benzobicyclo[3.2.1]octane skeleton.	Phenethylamines	149-165	phenylethanolamine N-methyltransferase	Homo sapiens	92-96	
2913486-1	1989	The conformational and steric aspects of binding to phenylethanolamine N-methyltransferase (PNMT; EC 2.1.1.28) for phenylethanolamine substrates and phenylethylamine inhibitors were probed with three conformationally defined analogues (11, 12, and 13) of phenylethylamine (1) and phenylethanolamine (6) containing the benzobicyclo[3.2.1]octane skeleton.	Phenethylamines	255-271	phenylethanolamine N-methyltransferase	Homo sapiens	52-90	
2913486-1	1989	The conformational and steric aspects of binding to phenylethanolamine N-methyltransferase (PNMT; EC 2.1.1.28) for phenylethanolamine substrates and phenylethylamine inhibitors were probed with three conformationally defined analogues (11, 12, and 13) of phenylethylamine (1) and phenylethanolamine (6) containing the benzobicyclo[3.2.1]octane skeleton.	Phenethylamines	255-271	phenylethanolamine N-methyltransferase	Homo sapiens	92-96	
2913486-5	1989	This is consistent with previous findings that a fully extended conformation for the aminoethyl side chain of phenylethylamine inhibitors is optimal for PNMT binding.	Phenethylamines	110-126	phenylethanolamine N-methyltransferase	Homo sapiens	153-157	
3172133-7	1988	These stereochemical requirements derived from the norephedrines (7 and 8), the norpseudoephedrines (9 and 10), and the 2-amino-1-tetralols (13-16) complement those for phenylethylamines (1-4) and for phenylethanolamines (5 and 6) and strongly suggest that phenylethylamine inhibitors bind to PNMT in the same orientation as do phenylethanolamine substrates.	Phenethylamines	169-186	phenylethanolamine N-methyltransferase	Homo sapiens	293-297	
3172133-7	1988	These stereochemical requirements derived from the norephedrines (7 and 8), the norpseudoephedrines (9 and 10), and the 2-amino-1-tetralols (13-16) complement those for phenylethylamines (1-4) and for phenylethanolamines (5 and 6) and strongly suggest that phenylethylamine inhibitors bind to PNMT in the same orientation as do phenylethanolamine substrates.	Phenethylamines	169-185	phenylethanolamine N-methyltransferase	Homo sapiens	293-297	
7121446-0	1982	The remarkable substrate activity for phenylethanolamine N-methyltransferase of some conformationally defined phenylethylamines lacking a side-chain hydroxyl group.	Phenethylamines	110-127	phenylethanolamine N-methyltransferase	Homo sapiens	38-76