PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1849060-1 1991 Heptanol blocks sodium current (INa) in nerve, but its effects on cardiac INa have not been well characterized. Heptanol 0-8 internexin neuronal intermediate filament protein alpha Canis lupus familiaris 32-35 1849060-1 1991 Heptanol blocks sodium current (INa) in nerve, but its effects on cardiac INa have not been well characterized. Heptanol 0-8 internexin neuronal intermediate filament protein alpha Canis lupus familiaris 74-77 1849060-2 1991 Block of INa by heptanol was studied in 16 internally perfused voltage-clamped cardiac Purkinje cells at reduced Na+ (45 mM outside, 0 mM inside). Heptanol 16-24 internexin neuronal intermediate filament protein alpha Canis lupus familiaris 9-12 1849060-4 1991 With 1.5 mM heptanol, block increased slightly by 0.7%/degrees C from 10 degrees C to 27 degrees C. With 3.0 mM heptanol, steady-state availability shifted by 9.4 +/- 1.3 mV (n = 6) in the hyperpolarizing direction, and steady-state activation shifted by 8.3 +/- 2.2 mV (n = 5) in the depolarizing direction, thus closing off the INa "window current." Heptanol 112-120 internexin neuronal intermediate filament protein alpha Canis lupus familiaris 330-333 1849060-5 1991 Heptanol also decreased the time to peak and accelerated the decay of INa. Heptanol 0-8 internexin neuronal intermediate filament protein alpha Canis lupus familiaris 70-73