PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22185819-4	2012	Concurrent with the cell cycle arrest of MCF7 cells, artemisinin selectively downregulated the transcript and protein levels of the CDK2 and CDK4 cyclin-dependent kinases, cyclin E, cyclin D1, and the E2F1 transcription factor.	artemisinin	53-64	cyclin dependent kinase 2	Homo sapiens	132-136	
24296733-2	2014	Artemisinin induced a G1 cell cycle arrest in cultured human Ishikawa endometrial cancer cells and downregulated cyclin-dependent kinase-2 (CDK2) and CDK4 transcript and protein levels.	artemisinin	0-11	cyclin dependent kinase 2	Homo sapiens	113-138	
24296733-2	2014	Artemisinin induced a G1 cell cycle arrest in cultured human Ishikawa endometrial cancer cells and downregulated cyclin-dependent kinase-2 (CDK2) and CDK4 transcript and protein levels.	artemisinin	0-11	cyclin dependent kinase 2	Homo sapiens	140-144	
22185819-5	2012	Analysis of CDK2 promoter-luciferase reporter constructs showed that the artemisinin ablation of CDK2 gene expression was accounted for by the loss of CDK2 promoter activity.	artemisinin	73-84	cyclin dependent kinase 2	Homo sapiens	12-16	
22185819-5	2012	Analysis of CDK2 promoter-luciferase reporter constructs showed that the artemisinin ablation of CDK2 gene expression was accounted for by the loss of CDK2 promoter activity.	artemisinin	73-84	cyclin dependent kinase 2	Homo sapiens	97-101	
22185819-5	2012	Analysis of CDK2 promoter-luciferase reporter constructs showed that the artemisinin ablation of CDK2 gene expression was accounted for by the loss of CDK2 promoter activity.	artemisinin	73-84	cyclin dependent kinase 2	Homo sapiens	97-101	
22185819-6	2012	Chromatin immunoprecipitation revealed that artemisinin inhibited E2F1 interactions with the endogenous MCF7 cell CDK2 and cyclin E promoters.	artemisinin	44-55	cyclin dependent kinase 2	Homo sapiens	114-118	
19017637-2	2009	We have observed that artemisinin treatment triggers a stringent G1 cell cycle arrest of LNCaP (lymph node carcinoma of the prostate) human prostate cancer cells that is accompanied by a rapid down-regulation of CDK2 and CDK4 protein and transcript levels.	artemisinin	22-33	cyclin dependent kinase 2	Homo sapiens	212-216	
19017637-3	2009	Transient transfection with promoter-linked luciferase reporter plasmids revealed that artemisinin strongly inhibits CDK2 and CDK4 promoter activity.	artemisinin	87-98	cyclin dependent kinase 2	Homo sapiens	117-121