PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24513447-4 2014 Depending on the exposure window, TBT promoted subsequent adipogenesis independently and dependently from PPARgamma. tributyltin 34-37 peroxisome proliferator activated receptor gamma Mus musculus 106-115 28977589-4 2017 Mesenchymal stem cells (MSCs) from these mice are biased toward the adipose lineage at the expense of the osteoblast lineage, and MSCs exposed to TBT in vitro are shunted toward the adipose fate in a PPARgamma-dependent fashion. tributyltin 146-149 peroxisome proliferator activated receptor gamma Mus musculus 200-209 26243053-2 2015 Evidence implicates various EDCs as being proadipogenic, including tributyltin (TBT), which activates the peroxisome proliferator activated receptor-gamma (PPARgamma). tributyltin 80-83 peroxisome proliferator activated receptor gamma Mus musculus 106-154 26243053-2 2015 Evidence implicates various EDCs as being proadipogenic, including tributyltin (TBT), which activates the peroxisome proliferator activated receptor-gamma (PPARgamma). tributyltin 80-83 peroxisome proliferator activated receptor gamma Mus musculus 156-165 24513447-2 2014 Although prenatal TBT exposure has been shown to induce obesity, the underlying mechanisms and the role of the transcription factor PPARgamma are not clarified yet. tributyltin 18-21 peroxisome proliferator activated receptor gamma Mus musculus 132-141 24513447-5 2014 In undifferentiated MSC, TBT exposure induced a transcriptional PPARgamma-independent repression of Pref-1 and SOX9, which are both suppressors of adipogenic cell fate commitment. tributyltin 25-28 peroxisome proliferator activated receptor gamma Mus musculus 64-73 24513447-6 2014 During hormonal induction TBT additionally enhanced adipogenic differentiation by PPARgamma signaling. tributyltin 26-29 peroxisome proliferator activated receptor gamma Mus musculus 82-91 23322813-1 2013 BACKGROUND: We have previously shown that exposure to tributyltin (TBT) modulates critical steps of adipogenesis through RXR/PPARgamma and that prenatal TBT exposure predisposes multipotent mesenchymal stem cells (MSCs) to become adipocytes by epigenetic imprinting into the memory of the MSC compartment. tributyltin 54-65 peroxisome proliferator activated receptor gamma Mus musculus 125-134 23322813-1 2013 BACKGROUND: We have previously shown that exposure to tributyltin (TBT) modulates critical steps of adipogenesis through RXR/PPARgamma and that prenatal TBT exposure predisposes multipotent mesenchymal stem cells (MSCs) to become adipocytes by epigenetic imprinting into the memory of the MSC compartment. tributyltin 67-70 peroxisome proliferator activated receptor gamma Mus musculus 125-134 21397693-0 2011 The environmental obesogen tributyltin chloride acts via peroxisome proliferator activated receptor gamma to induce adipogenesis in murine 3T3-L1 preadipocytes. tributyltin 27-47 peroxisome proliferator activated receptor gamma Mus musculus 57-105 21397693-3 2011 While it is known that TBT acts through peroxisome proliferator activated receptor gamma to induce adipogenesis in MSCs, the data in 3T3-L1 preadipocytes are controversial. tributyltin 23-26 peroxisome proliferator activated receptor gamma Mus musculus 40-88 21397693-4 2011 Here we show that TBT can activate the RXR-PPARgamma heterodimer even in the presence of the PPARgamma antagonist GW9662. tributyltin 18-21 peroxisome proliferator activated receptor gamma Mus musculus 43-52 21397693-4 2011 Here we show that TBT can activate the RXR-PPARgamma heterodimer even in the presence of the PPARgamma antagonist GW9662. tributyltin 18-21 peroxisome proliferator activated receptor gamma Mus musculus 93-102 21397693-6 2011 When the culture conditions are adjusted to compensate for the short half-life of GW9662, we found that TBT induces adipogenesis, triglyceride storage and the expression of adipogenic marker genes in 3T3-L1 cells in a PPARgamma-dependent manner. tributyltin 104-107 peroxisome proliferator activated receptor gamma Mus musculus 218-227 20160124-2 2010 Tributyltin (TBT) is an agonist of both retinoid X receptor (RXR) and peroxisome proliferator-activated receptor gamma (PPARgamma). tributyltin 0-11 peroxisome proliferator activated receptor gamma Mus musculus 70-118 21219878-2 2011 TBTC has been shown to activate nuclear receptor retinoid X receptor (RXR)/PPARgamma signaling by interacting with RXR to modulate adipogenesis. tributyltin 0-4 peroxisome proliferator activated receptor gamma Mus musculus 75-84 20160124-2 2010 Tributyltin (TBT) is an agonist of both retinoid X receptor (RXR) and peroxisome proliferator-activated receptor gamma (PPARgamma). tributyltin 0-11 peroxisome proliferator activated receptor gamma Mus musculus 120-129 20160124-2 2010 Tributyltin (TBT) is an agonist of both retinoid X receptor (RXR) and peroxisome proliferator-activated receptor gamma (PPARgamma). tributyltin 13-16 peroxisome proliferator activated receptor gamma Mus musculus 70-118 20160124-2 2010 Tributyltin (TBT) is an agonist of both retinoid X receptor (RXR) and peroxisome proliferator-activated receptor gamma (PPARgamma). tributyltin 13-16 peroxisome proliferator activated receptor gamma Mus musculus 120-129 20160124-6 2010 The adipogenic effects of TBT and rosiglitazone were blocked by the addition of PPARgamma antagonists, suggesting that activation of PPARgamma mediates the effect of both compounds on adipogenesis. tributyltin 26-29 peroxisome proliferator activated receptor gamma Mus musculus 80-89 20160124-6 2010 The adipogenic effects of TBT and rosiglitazone were blocked by the addition of PPARgamma antagonists, suggesting that activation of PPARgamma mediates the effect of both compounds on adipogenesis. tributyltin 26-29 peroxisome proliferator activated receptor gamma Mus musculus 133-142 20160124-8 2010 ADSCs retrieved from animals exposed to TBT in utero showed increased expression of PPARgamma target genes such as the early adipogenic differentiation gene marker fatty acid-binding protein 4 and hypomethylation of the promoter/enhancer region of the fatty acid-binding protein 4 locus. tributyltin 40-43 peroxisome proliferator activated receptor gamma Mus musculus 84-93 18248399-9 2008 TBT promotes adipogenesis in the murine 3T3-L1 cell model and perturbs key regulators of adipogenesis and lipogenic pathways in vivo, primarily through activation of RXRalpha and PPARgamma. tributyltin 0-3 peroxisome proliferator activated receptor gamma Mus musculus 179-188 18501494-3 2008 Recently, it has been shown that tri-butyltin (TBT) interacts with nuclear receptors PPAR gamma (peroxisome proliferator-activated receptor gamma) and RXR (retinoid x receptor) leading to adipocyte differentiation in the 3T3 cell line. tributyltin 33-45 peroxisome proliferator activated receptor gamma Mus musculus 85-145 18501494-3 2008 Recently, it has been shown that tri-butyltin (TBT) interacts with nuclear receptors PPAR gamma (peroxisome proliferator-activated receptor gamma) and RXR (retinoid x receptor) leading to adipocyte differentiation in the 3T3 cell line. tributyltin 47-50 peroxisome proliferator activated receptor gamma Mus musculus 85-145 16613991-5 2006 TBT is a dual, nanomolar affinity ligand for both the retinoid X receptor (RXR) and the peroxisome proliferator-activated receptor gamma (PPARgamma). tributyltin 0-3 peroxisome proliferator activated receptor gamma Mus musculus 88-136 16613991-5 2006 TBT is a dual, nanomolar affinity ligand for both the retinoid X receptor (RXR) and the peroxisome proliferator-activated receptor gamma (PPARgamma). tributyltin 0-3 peroxisome proliferator activated receptor gamma Mus musculus 138-147 16613991-9 2006 TBT represents, to our knowledge, the first example of an environmental endocrine disrupter that promotes adipogenesis through RXR and PPARgamma activation. tributyltin 0-3 peroxisome proliferator activated receptor gamma Mus musculus 135-144 29675927-1 2018 Tributyltin (TBT), a proven environmental obesogen, functions as a nanomolar agonist of the peroxisome proliferator activated receptor-gamma (PPARgamma). tributyltin 0-11 peroxisome proliferator activated receptor gamma Mus musculus 92-140 34619157-2 2021 We previously reported that the PPARgamma and retinoid X receptor dual ligand, tributyltin (TBT), repressed periosteal bone formation but enhanced trabecular bone formation in vivo. tributyltin 79-90 peroxisome proliferator activated receptor gamma Mus musculus 32-41 34619157-2 2021 We previously reported that the PPARgamma and retinoid X receptor dual ligand, tributyltin (TBT), repressed periosteal bone formation but enhanced trabecular bone formation in vivo. tributyltin 92-95 peroxisome proliferator activated receptor gamma Mus musculus 32-41 33383419-7 2021 And the in vivo results were consistent with cellular assays, confirming the induction of PPARgamma and the increased expression of lipogenesis-regulating and lipid metabolism-related genes by TBT in vivo. tributyltin 193-196 peroxisome proliferator activated receptor gamma Mus musculus 90-99 29380368-2 2018 Tributyltin (TBT) is an environmental contaminant that is a dual RXRalpha/beta and PPARgamma agonist. tributyltin 0-11 peroxisome proliferator activated receptor gamma Mus musculus 83-92 29380368-2 2018 Tributyltin (TBT) is an environmental contaminant that is a dual RXRalpha/beta and PPARgamma agonist. tributyltin 13-16 peroxisome proliferator activated receptor gamma Mus musculus 83-92 29380368-3 2018 TBT induces RXR, PPARgamma, and LXR-mediated gene transcription and suppresses osteoblast differentiation in vitro. tributyltin 0-3 peroxisome proliferator activated receptor gamma Mus musculus 17-26 29675927-1 2018 Tributyltin (TBT), a proven environmental obesogen, functions as a nanomolar agonist of the peroxisome proliferator activated receptor-gamma (PPARgamma). tributyltin 0-11 peroxisome proliferator activated receptor gamma Mus musculus 142-151 29675927-1 2018 Tributyltin (TBT), a proven environmental obesogen, functions as a nanomolar agonist of the peroxisome proliferator activated receptor-gamma (PPARgamma). tributyltin 13-16 peroxisome proliferator activated receptor gamma Mus musculus 92-140 29675927-1 2018 Tributyltin (TBT), a proven environmental obesogen, functions as a nanomolar agonist of the peroxisome proliferator activated receptor-gamma (PPARgamma). tributyltin 13-16 peroxisome proliferator activated receptor gamma Mus musculus 142-151