PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15239129-4 2004 MTT assays showed that after overexpressing caveolin-1, the drug resistance of Hs578T/Doxo cells to doxorubicin and cisplatin was reduced from 25.4 +/- 1.5 and 65.3 +/- 2.5 microg/ml to 0.8 +/- 0.15 and 23.2 +/- 2.1 microg/ml, respectively (i.e. reduced by 97% and 64%, respectively). Cisplatin 116-125 caveolin 1 Homo sapiens 44-54 31270811-0 2020 Caveolin-1 knockdown increases the therapeutic sensitivity of lung cancer to cisplatin-induced apoptosis by repressing Parkin-related mitophagy and activating the ROCK1 pathway. Cisplatin 77-86 caveolin 1 Homo sapiens 0-10 35622184-5 2022 Cav-1 overexpression enhanced sensitivity to cisplatin (CDDP) treatment, whereas Cav-1 deficiency promoted chemoresistance in OCCC cells. Cisplatin 45-54 caveolin 1 Homo sapiens 0-5 32117718-0 2020 Caveolin-1 Promotes Chemoresistance of Gastric Cancer Cells to Cisplatin by Activating WNT/beta-Catenin Pathway. Cisplatin 63-72 caveolin 1 Homo sapiens 0-10 32117718-3 2020 In this research, we showed that the survival rate of GC cells to cisplatin (CDDP) increased in the presence of Cav-1. Cisplatin 66-75 caveolin 1 Homo sapiens 112-117 32117718-3 2020 In this research, we showed that the survival rate of GC cells to cisplatin (CDDP) increased in the presence of Cav-1. Cisplatin 77-81 caveolin 1 Homo sapiens 112-117 32117718-4 2020 Moreover, Cav-1 overexpression inhibited cisplatin-induced apoptosis and improved the survival rate of GC cells. Cisplatin 41-50 caveolin 1 Homo sapiens 10-15 32117718-7 2020 Moreover, our results demonstrated that the expression of Cav-1 and Met were positively associated with the resistance of GC cells to cisplatin. Cisplatin 134-143 caveolin 1 Homo sapiens 58-63 32117718-8 2020 Collectively, Cav-1 enhances the cisplatin-resistance of GC cells by activating the WNT signaling pathway and Met-HER2 crosstalk. Cisplatin 33-42 caveolin 1 Homo sapiens 14-19 31270811-4 2020 Results in this study demonstrated that Cav-1 levels were markedly inhibited in A549 lung cancer cells after exposure to cisplatin. Cisplatin 121-130 caveolin 1 Homo sapiens 40-45 31270811-6 2020 The functional investigation demonstrated that Cav-1 inhibition amplified the mitochondrial stress signaling induced by cisplatin, as evidenced by the mitochondrial reactive oxygen species burst, cellular metabolic disruption, mitochondrial membrane potential reduction, and mitochondrial caspase-9-related apoptosis activation. Cisplatin 120-129 caveolin 1 Homo sapiens 47-52 31270811-7 2020 At the molecular level, cav-1 augmented cisplatin-mediated mitochondrial damage by inhibiting Parkin-related mitochondrial autophagy. Cisplatin 40-49 caveolin 1 Homo sapiens 24-29 31270811-10 2020 Taken together, our results provide ample data illuminate the necessary action exerted by Cav-1 on affecting cisplatin-related therapeutic resistance. Cisplatin 109-118 caveolin 1 Homo sapiens 90-95 31270811-11 2020 Silencing of Cav-1 inhibited Parkin-related mitophagy, thus amplifying cisplatin-mediated mitochondrial apoptotic signaling. Cisplatin 71-80 caveolin 1 Homo sapiens 13-18 31270811-12 2020 This finding identifies the Cav-1/ROCK1/Parkin/mitophagy axis as a potential target to overcome cisplatin-related resistance in lung cancer cells. Cisplatin 96-105 caveolin 1 Homo sapiens 28-33 30901662-0 2019 Chrysotobibenzyl inhibition of lung cancer cell migration through Caveolin-1-dependent mediation of the integrin switch and the sensitization of lung cancer cells to cisplatin-mediated apoptosis. Cisplatin 166-175 caveolin 1 Homo sapiens 66-76 30981205-0 2019 MiR-204 reduces cisplatin resistance in non-small cell lung cancer through suppression of the caveolin-1/AKT/Bad pathway. Cisplatin 16-25 caveolin 1 Homo sapiens 94-104 30981205-6 2019 Furthermore, we demonstrated that the downregulation of miR-204 expression was responsible for CAV-1 overexpression in these cisplatin-resistant NSCLC cells. Cisplatin 125-134 caveolin 1 Homo sapiens 95-100 30981205-7 2019 We then found that enforced expression of miR-204 can resensitize CR-A549 and CR-PC9 cells to cisplatin-induced mitochondrial apoptosis through suppression of the caveolin-1/AKT/Bad pathway. Cisplatin 94-103 caveolin 1 Homo sapiens 163-173 30554070-5 2019 Among them, complex 3 with a leaving group PPh3 was found to be the most efficacious complex against certain cell lines, especially for cisplatin-resistant A549cisR cells. Cisplatin 136-145 caveolin 1 Homo sapiens 43-47 26503358-0 2015 Caveolin-1 mediates chemoresistance in cisplatin-resistant ovarian cancer cells by targeting apoptosis through the Notch-1/Akt/NF-kappaB pathway. Cisplatin 39-48 caveolin 1 Homo sapiens 0-10 29914219-0 2018 Poly(alkylidenimine) Dendrimers Functionalized with the Organometallic Moiety [Ru(eta5-C5H5)(PPh3)2]+ as Promising Drugs Against Cisplatin-Resistant Cancer Cells and Human Mesenchymal Stem Cells. Cisplatin 129-138 caveolin 1 Homo sapiens 93-97 29914219-2 2018 Importantly, both the RuCp and the dendrimers functionalized with [Ru(eta5-C5H5)(PPh3)2]+ fragments present remarkable toxicity towards a wide set of cancer cells (Caco-2, MCF-7, CAL-72, and A2780 cells), including cisplatin-resistant human ovarian carcinoma cell lines (A2780cisR cells). Cisplatin 215-224 caveolin 1 Homo sapiens 81-85 26503358-7 2015 Knockdown of Cav-1 significantly decreased the IC50 value in cisplatin-resistant cells. Cisplatin 61-70 caveolin 1 Homo sapiens 13-18 26503358-9 2015 The apoptotic ratio induced by cisplatin in normal ovarian cancer cells was higher than cisplatin-resistant ovarian cancer cells, and knockdown of Cav-1 could significantly enhance cisplatin induced cell apoptosis. Cisplatin 31-40 caveolin 1 Homo sapiens 147-152 26503358-9 2015 The apoptotic ratio induced by cisplatin in normal ovarian cancer cells was higher than cisplatin-resistant ovarian cancer cells, and knockdown of Cav-1 could significantly enhance cisplatin induced cell apoptosis. Cisplatin 88-97 caveolin 1 Homo sapiens 147-152 26503358-9 2015 The apoptotic ratio induced by cisplatin in normal ovarian cancer cells was higher than cisplatin-resistant ovarian cancer cells, and knockdown of Cav-1 could significantly enhance cisplatin induced cell apoptosis. Cisplatin 88-97 caveolin 1 Homo sapiens 147-152 26503358-10 2015 Furthermore, knockdown of Cav-1 was also able to significantly downregulate the protein expression level of Notch-1, p-Akt and p-NF-kappaB p65 in cisplatin-resistant ovarian cancer cells. Cisplatin 146-155 caveolin 1 Homo sapiens 26-31 22593444-7 2012 Exposure to cisplatin induced superoxide anion and hydrogen peroxide generation; however, only hydrogen peroxide was found to be responsible for the CAV1 elevation. Cisplatin 12-21 caveolin 1 Homo sapiens 149-153 24935091-4 2014 The results show that the substitution of the PPh3 ligand by PEt3 is particularly effective in increasing the cytotoxicity of the dinuclear [(AuPR3)2(xspa)] complexes, giving rise to compounds that are significantly more active than cisplatin against the aforementioned cell lines. Cisplatin 233-242 caveolin 1 Homo sapiens 46-50 22545709-4 2012 We demonstrate that higher expression of Caveolin-1 leads to inhibition of cisplatin and Ultraviolet Radiation (UVR)-induced apoptosis in SCLC cells; and also could decrease caspase-3 activity and increase the stability of Bcl-2 at the protein level. Cisplatin 75-84 caveolin 1 Homo sapiens 41-51 22593444-0 2012 Sub-toxic cisplatin mediates anoikis resistance through hydrogen peroxide-induced caveolin-1 up-regulation in non-small cell lung cancer cells. Cisplatin 10-19 caveolin 1 Homo sapiens 82-92 22593444-8 2012 CONCLUSION: Exposure to cisplatin at sub-toxic concentrations induced hydrogen peroxide generation and the subsequent increase of ROS further regulated CAV1 levels and anoikis resistance. Cisplatin 24-33 caveolin 1 Homo sapiens 152-156 21761200-0 2011 Caveolin-1 sensitizes cisplatin-induced lung cancer cell apoptosis via superoxide anion-dependent mechanism. Cisplatin 22-31 caveolin 1 Homo sapiens 0-10 21761200-2 2011 This study reveals for the first time that Cav-1 sensitizes cisplatin-induced lung carcinoma cell death by the mechanism involving oxidative stress modulation. Cisplatin 60-69 caveolin 1 Homo sapiens 43-48 21761200-5 2011 Inhibitory study revealed that superoxide anion inhibitor MnTBAP could inhibit cisplatin-mediated toxicity only in H460/Cav-1 cells while had no effect on H460 cells. Cisplatin 79-88 caveolin 1 Homo sapiens 120-125 21761200-6 2011 Further, superoxide anion detected by DHE probe indicated that H460/Cav-1 cells generated significantly higher superoxide anion level in response to cisplatin than that of control cells. Cisplatin 149-158 caveolin 1 Homo sapiens 68-73 21761200-7 2011 The role of Cav-1 in regulating cisplatin sensitivity was confirmed in shRNA-mediated Cav-1 down-regulated (H460/shCav-1) cells and the cells exhibited decreased cisplatin susceptibility and superoxide generation. Cisplatin 32-41 caveolin 1 Homo sapiens 12-17 21761200-7 2011 The role of Cav-1 in regulating cisplatin sensitivity was confirmed in shRNA-mediated Cav-1 down-regulated (H460/shCav-1) cells and the cells exhibited decreased cisplatin susceptibility and superoxide generation. Cisplatin 32-41 caveolin 1 Homo sapiens 86-91 21761200-7 2011 The role of Cav-1 in regulating cisplatin sensitivity was confirmed in shRNA-mediated Cav-1 down-regulated (H460/shCav-1) cells and the cells exhibited decreased cisplatin susceptibility and superoxide generation. Cisplatin 162-171 caveolin 1 Homo sapiens 12-17 21761200-7 2011 The role of Cav-1 in regulating cisplatin sensitivity was confirmed in shRNA-mediated Cav-1 down-regulated (H460/shCav-1) cells and the cells exhibited decreased cisplatin susceptibility and superoxide generation. Cisplatin 162-171 caveolin 1 Homo sapiens 86-91 21761200-8 2011 In summary, these findings reveal novel aspects regarding role of Cav-1 in modulating oxidative stress induced by cisplatin, possibly providing new insights for cancer biology and cisplatin-based chemotherapy. Cisplatin 114-123 caveolin 1 Homo sapiens 66-71 21761200-8 2011 In summary, these findings reveal novel aspects regarding role of Cav-1 in modulating oxidative stress induced by cisplatin, possibly providing new insights for cancer biology and cisplatin-based chemotherapy. Cisplatin 180-189 caveolin 1 Homo sapiens 66-71 19228729-11 2009 CONCLUSIONS: The high cytotoxicity of cisplatin nanocapsules requires caveolin-1-dependent endocytosis that is followed by release of the drug from a late endosomal/lysosomal compartment and cisplatin-DNA-adduct formation. Cisplatin 38-47 caveolin 1 Homo sapiens 70-80 19609943-6 2010 Moreover, results from antisense- and shRNA-mediated gene expression knockdown and protein re-expression experiments demonstrated that CAV1 increases the resistance of ESFT cells to doxorubicin (Dox)- and cisplatin (Cp)-induced apoptosis by a mechanism involving the activating phosphorylation of PKCalpha. Cisplatin 205-214 caveolin 1 Homo sapiens 135-139 15856296-0 2005 Expression of caveolin-1 and its correlation with cisplatin sensitivity in oral squamous cell carcinoma. Cisplatin 50-59 caveolin 1 Homo sapiens 14-24 15856296-12 2005 Positive immunohistochemical staining of caveolin-1 correlated positively with chemosensitivity to CDDP-based combination chemotherapy (P=0.02). Cisplatin 99-103 caveolin 1 Homo sapiens 41-51 15856296-13 2005 CONCLUSIONS: These results suggest that overexpression of the caveolin-1 gene may provide novel diagnostic markers associated with CDDP sensitivity in OSCC. Cisplatin 131-135 caveolin 1 Homo sapiens 62-72