PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19144695-0 2009 Anaphylatoxin C5a contributes to the pathogenesis of cisplatin-induced nephrotoxicity. Cisplatin 53-62 hemolytic complement Mus musculus 14-17 19144695-2 2009 In this study, we investigated the role of anaphylatoxin C5a in the pathogenesis of cisplatin-mediated nephrotoxicity. Cisplatin 84-93 hemolytic complement Mus musculus 57-60 19144695-4 2009 However, pretreatment with C5 or C5a restores sensitivity to cisplatin-induced nephrotoxicity in C5-deficient mice. Cisplatin 61-70 hemolytic complement Mus musculus 33-36 19144695-8 2009 In conclusion, our findings suggest that C5a plays an important role in the pathogenesis of cisplatin nephrotoxicity. Cisplatin 92-101 hemolytic complement Mus musculus 41-44 31111056-5 2019 Furthermore, C5a and C5aR expression in the cisplatin-treated group was notably increased compared with the control group, and this increase could be significantly inhibited by NAC. Cisplatin 44-53 hemolytic complement Mus musculus 13-16