PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24434152-0	2014	PTEN overexpression improves cisplatin-resistance of human ovarian cancer cells through upregulating KRT10 expression.	Cisplatin	29-38	keratin 10	Homo sapiens	101-106	
26125866-0	2015	Recombinant adenovirus-mediated overexpression of PTEN and KRT10 improves cisplatin resistance of ovarian cancer in vitro and in vivo.	Cisplatin	74-83	keratin 10	Homo sapiens	59-64	
26125866-2	2015	Overexpression of phosphatase and tensin homolog (PTEN) has been shown to preserve the cisplatin-resistance of ovarian cancer cells, while cisplatin-induced keratin 10 (KRT10) overexpression mediates the resistance-reversing effect of PTEN.	Cisplatin	139-148	keratin 10	Homo sapiens	157-167	
26125866-2	2015	Overexpression of phosphatase and tensin homolog (PTEN) has been shown to preserve the cisplatin-resistance of ovarian cancer cells, while cisplatin-induced keratin 10 (KRT10) overexpression mediates the resistance-reversing effect of PTEN.	Cisplatin	139-148	keratin 10	Homo sapiens	169-174	
26125866-3	2015	However, whether overexpression of PTEN or KRT10 can improve the cisplatin resistance of ovarian cancer in vivo has not been investigated.	Cisplatin	65-74	keratin 10	Homo sapiens	43-48	
26125866-6	2015	The effects of overexpression of PTEN and KRT10 on cisplatin resistance of ovarian cancer cells were examined using the 3(4,5-dimethylthiazol-2-yl)2,5-diphenyltetrazolium bromide (MTT) and TdT-mediated dUTP nick-end labeling (TUNEL) assays in vitro.	Cisplatin	51-60	keratin 10	Homo sapiens	42-47	
26125866-8	2015	The MTT assay showed that recombinant adenovirus-mediated overexpression of KRT10 and PTEN enhanced the proliferation inhibition effect of cisplatin on C13K cells.	Cisplatin	139-148	keratin 10	Homo sapiens	76-81	
26125866-9	2015	Recombinant adenovirus-mediated overexpression of KRT10 and PTEN also increased the cisplatin-induced apoptosis rate of C13K cells.	Cisplatin	84-93	keratin 10	Homo sapiens	50-55	
26125866-10	2015	Furthermore, recombinant adenovirus-mediated overexpression of KRT10 and PTEN enhanced the inhibitory effect of cisplatin on C13K xenograft tumor growth.	Cisplatin	112-121	keratin 10	Homo sapiens	63-68	
26125866-11	2015	Thus, recombinant adenovirus-mediated overexpression of KRT10 and PTEN may improve the cisplatin resistance of ovarian cancer in vitro and in vivo.	Cisplatin	87-96	keratin 10	Homo sapiens	56-61	
24434152-8	2014	KRT10 was identified as a differently expressed protein in cisplatin-treated C13K/PTEN cells.	Cisplatin	59-68	keratin 10	Homo sapiens	0-5	
24434152-9	2014	Further study confirmed that cisplatin could induce upregulation of KRT10 mRNA and protein in C13K/PTEN cells and there was a directly interaction between KRT10 and PTEN.	Cisplatin	29-38	keratin 10	Homo sapiens	68-73	
24434152-9	2014	Further study confirmed that cisplatin could induce upregulation of KRT10 mRNA and protein in C13K/PTEN cells and there was a directly interaction between KRT10 and PTEN.	Cisplatin	29-38	keratin 10	Homo sapiens	155-160	
24434152-10	2014	Forced expression of KRT10 in C13K cells also enhanced cisplatin-induced proliferation inhibition and apoptosis of C13K cells.	Cisplatin	55-64	keratin 10	Homo sapiens	21-26	
24434152-11	2014	In addition, KRT10 siRNA blocked cisplatin-induced proliferation inhibition of C13K/PTEN cells.	Cisplatin	33-42	keratin 10	Homo sapiens	13-18	
24434152-12	2014	In conclusion, our data demonstrate that KRT10 is a downstream molecule of PTEN which improves cisplatin-resistance of ovarian cancer and forced KRT10 overexpression may also act as a therapeutic method for overcoming MDR in ovarian cancer.	Cisplatin	95-104	keratin 10	Homo sapiens	41-46