PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27473273-8	2016	siRNA-mediated silencing of the FA-associated genes FANCL and RAD18 and the HR-associated genes BRCA1 and BRCA2 significantly potentiated the sensitivity of A549/DR cells to cisplatin compared to A549 and Calu-1 cells, suggesting that the acquired cisplatin resistance in A549/DR cells may be attributed to enhanced FA and HR pathway capacities responsible for ICL repair.	Cisplatin	174-183	RAD18 E3 ubiquitin protein ligase	Homo sapiens	62-67	
20028736-3	2010	First, we determined that PCNA monoubiquitination by RAD18 is necessary for efficient bypass of cisplatin adducts by the TLS polymerases eta (Poleta), REV1, and zeta (Polzeta) based on the observations that depletion of these proteins individually leads to decreased cell survival, cell cycle arrest in S phase, and activation of the DNA damage response.	Cisplatin	96-105	RAD18 E3 ubiquitin protein ligase	Homo sapiens	53-58	
20028736-6	2010	Together, our findings indicate that REV1 and Polzeta facilitate repair of interstrand cross-links independently of PCNA monoubiquitination and Poleta, whereas RAD18 plus Poleta, REV1, and Polzeta are all necessary for replicative bypass of cisplatin intrastrand DNA cross-links.	Cisplatin	241-250	RAD18 E3 ubiquitin protein ligase	Homo sapiens	160-165	
14981545-7	2004	However, treatment with ADR or cisplatin is accompanied by a significant increase and redistribution of RAD6 to DNA, and RAD6, RAD18, PCNA, phosphohistone H3, as well as p53 proteins are all found in the DNA fractions.	Cisplatin	31-40	RAD18 E3 ubiquitin protein ligase	Homo sapiens	127-132	
27868409-7	2016	After treatment with different concentrations of cisplatin or 5-FU, the survival rate of the two cell groups was reduced (all P<0.05), and the IC50 of RAD18-siRNA group was significantly lower than that of non-transfected group (P<0.05).	Cisplatin	49-58	RAD18 E3 ubiquitin protein ligase	Homo sapiens	154-159	
26819410-3	2016	Expression profiling revealed wide-spread transcriptional regulation of DNA repair genes and in particular Fanconi anemia (FA) pathway components such as FANCD2 and RAD18 - known to be crucial for the repair of cisplatin-induced interstrand crosslinks.	Cisplatin	211-220	RAD18 E3 ubiquitin protein ligase	Homo sapiens	165-170