PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31579410-10 2019 Furthermore, levels of p-DVL-2Ser143 and major Wnt-signaling proteins decreased significantly after treatment of A549/DDP cells with CX4945+cisplatin, whereas DVL-2 and p-DVL-2Thr224 levels remained unchanged. Cisplatin 140-149 dishevelled segment polarity protein 2 Homo sapiens 25-30 27432651-4 2016 Here, we found that DVL2 was over-expressed in cisplatin-resistant human lung cancer cells A549/CDDP compared to the parental A549 cells. Cisplatin 47-56 dishevelled segment polarity protein 2 Homo sapiens 20-24 27432651-4 2016 Here, we found that DVL2 was over-expressed in cisplatin-resistant human lung cancer cells A549/CDDP compared to the parental A549 cells. Cisplatin 96-100 dishevelled segment polarity protein 2 Homo sapiens 20-24 27432651-5 2016 Inhibition of DVL2 by its inhibitor (3289-8625) or shDVL2 resensitized A549/CDDP cells to cisplatin. Cisplatin 90-99 dishevelled segment polarity protein 2 Homo sapiens 14-18 27432651-9 2016 Taken together, these results suggested that inhibition of DVL2 can sensitize cisplatin-resistant lung cancer cells through down-regulating Wnt/beta-catenin signaling and inhibiting BCRP, MRP4, and Survivin expression. Cisplatin 78-87 dishevelled segment polarity protein 2 Homo sapiens 59-63