PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31061066-0 2019 Targeting the High-Mobility Group Box 3 Protein Sensitizes Chemoresistant Ovarian Cancer Cells to Cisplatin. Cisplatin 98-107 high mobility group box 3 Homo sapiens 14-39 31061066-3 2019 In this study, we report that cisplatin sensitivity can be restored in cisplatin-resistant ovarian cancer cells by targeting the chromatin-associated high-mobility group box 3 (HMGB3) protein. Cisplatin 30-39 high mobility group box 3 Homo sapiens 150-175 31061066-3 2019 In this study, we report that cisplatin sensitivity can be restored in cisplatin-resistant ovarian cancer cells by targeting the chromatin-associated high-mobility group box 3 (HMGB3) protein. Cisplatin 30-39 high mobility group box 3 Homo sapiens 177-182 31061066-3 2019 In this study, we report that cisplatin sensitivity can be restored in cisplatin-resistant ovarian cancer cells by targeting the chromatin-associated high-mobility group box 3 (HMGB3) protein. Cisplatin 71-80 high mobility group box 3 Homo sapiens 150-175 31061066-3 2019 In this study, we report that cisplatin sensitivity can be restored in cisplatin-resistant ovarian cancer cells by targeting the chromatin-associated high-mobility group box 3 (HMGB3) protein. Cisplatin 71-80 high mobility group box 3 Homo sapiens 177-182 31061066-5 2019 Depletion of HMGB3 in cisplatin-sensitive and cisplatin-resistant cells resulted in transcriptional downregulation of the kinases ATR and CHK1, which attenuated the ATR/CHK1/p-CHK1 DNA damage signaling pathway. Cisplatin 22-31 high mobility group box 3 Homo sapiens 13-18 31061066-5 2019 Depletion of HMGB3 in cisplatin-sensitive and cisplatin-resistant cells resulted in transcriptional downregulation of the kinases ATR and CHK1, which attenuated the ATR/CHK1/p-CHK1 DNA damage signaling pathway. Cisplatin 46-55 high mobility group box 3 Homo sapiens 13-18 31061066-7 2019 Furthermore, HMGB3 depletion significantly increased apoptosis in cisplatin-resistant A2780/CP70 cells after cisplatin treatment. Cisplatin 66-75 high mobility group box 3 Homo sapiens 13-18 31061066-7 2019 Furthermore, HMGB3 depletion significantly increased apoptosis in cisplatin-resistant A2780/CP70 cells after cisplatin treatment. Cisplatin 109-118 high mobility group box 3 Homo sapiens 13-18 31061066-8 2019 Taken together, our results indicate that targeted depletion of HMGB3 attenuates cisplatin resistance in human ovarian cancer cells, increasing tumor cell sensitivity to platinum drugs. Cisplatin 81-90 high mobility group box 3 Homo sapiens 64-69 27774979-12 2016 Silencing of HMGB3 enhanced sensitive to cisplatin and paclitaxel, and reduced sensitive to oxaliplatin. Cisplatin 41-50 high mobility group box 3 Homo sapiens 13-18