PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25756333-1	2015	The reaction between cis-diamminedichloroplatinum(II) (CDDP), cisplatin, a common anticancer drug, and bovine pancreatic ribonuclease (RNase A), induces extensive protein aggregation, leading to the formation of one dimer, one trimer and higher oligomers whose yields depend on cisplatin/protein ratio.	Cisplatin	21-53	ribonuclease pancreatic	Bos taurus	135-142	
28511060-0	2017	A comparison study on RNase A oligomerization induced by cisplatin, carboplatin and oxaliplatin.	Cisplatin	57-66	ribonuclease pancreatic	Bos taurus	22-29	
28511060-2	2017	A dimer, a trimer and higher oligomers of bovine pancreatic ribonuclease (RNase A) obtained upon reaction with CDDP in 1:10 protein to metal ratio at 37 C have been previously characterized.	Cisplatin	111-115	ribonuclease pancreatic	Bos taurus	74-81	
28511060-10	2017	Although platinated oligomers of RNase A formed upon reaction with CDDP, carboplatin and oxaliplatin retain a residual ribonuclease activity, they do not show cytotoxic action, suggesting that protein aggregation processes induced by Pt-based drugs can represent a collateral drawback, which affects the functional state of protein targets and reduces the efficacy of Pt-based drug treatment.	Cisplatin	67-71	ribonuclease pancreatic	Bos taurus	33-40	
26239545-2	2015	Here, the X-ray structures of the adducts formed upon reaction of carboplatin and oxaliplatin with bovine pancreatic ribonuclease (RNase A) are reported and compared with results obtained for the structure of the RNase A-cisplatin adduct derived from isomorphous crystals, under the same experimental conditions.	Cisplatin	221-230	ribonuclease pancreatic	Bos taurus	131-138	
25756333-1	2015	The reaction between cis-diamminedichloroplatinum(II) (CDDP), cisplatin, a common anticancer drug, and bovine pancreatic ribonuclease (RNase A), induces extensive protein aggregation, leading to the formation of one dimer, one trimer and higher oligomers whose yields depend on cisplatin/protein ratio.	Cisplatin	55-59	ribonuclease pancreatic	Bos taurus	135-142	
25756333-1	2015	The reaction between cis-diamminedichloroplatinum(II) (CDDP), cisplatin, a common anticancer drug, and bovine pancreatic ribonuclease (RNase A), induces extensive protein aggregation, leading to the formation of one dimer, one trimer and higher oligomers whose yields depend on cisplatin/protein ratio.	Cisplatin	62-71	ribonuclease pancreatic	Bos taurus	135-142	
25756333-1	2015	The reaction between cis-diamminedichloroplatinum(II) (CDDP), cisplatin, a common anticancer drug, and bovine pancreatic ribonuclease (RNase A), induces extensive protein aggregation, leading to the formation of one dimer, one trimer and higher oligomers whose yields depend on cisplatin/protein ratio.	Cisplatin	278-287	ribonuclease pancreatic	Bos taurus	135-142