PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35355868-0 2022 Regulation of ACSL4-Catalyzed Lipid Peroxidation Process Resists Cisplatin Ototoxicity. Cisplatin 65-74 acyl-CoA synthetase long chain family member 4 Homo sapiens 14-19 35355868-2 2022 Our study aimed to investigate the effect of ACSL4-catalyzed lipid peroxidation on cisplatin-induced hearing loss and its possible protective mechanisms. Cisplatin 83-92 acyl-CoA synthetase long chain family member 4 Homo sapiens 45-50 35355868-10 2022 Further, we reduced the level of lipid peroxide in hair cells by specifically inhibiting the expression of ACSL4, which protected hair cells from cisplatin damage at source. Cisplatin 146-155 acyl-CoA synthetase long chain family member 4 Homo sapiens 107-112 35355868-11 2022 In conclusion, the lipid peroxidation process regulated by ACSL4 may be an important factor contributing to the sensitivity of hair cells to cisplatin. Cisplatin 141-150 acyl-CoA synthetase long chain family member 4 Homo sapiens 59-64 35355868-12 2022 Inhibition of ACSL4 expression may be an effective preventive measure against cisplatin ototoxicity. Cisplatin 78-87 acyl-CoA synthetase long chain family member 4 Homo sapiens 14-19