PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19615253-7 2009 Cisplatin (DDP) resistance experiment was performed in SKOV3/DDP cells with RNAi. Cisplatin 0-9 translocase of inner mitochondrial membrane 8A Homo sapiens 11-14 19200747-1 2009 cis-Diamminedichloroplatinum(II) (cisplatin, DDP) is a cornerstone of anticancer therapy and has become one of the most widely used drugs for the treatment of various epithelial malignancies. Cisplatin 0-28 translocase of inner mitochondrial membrane 8A Homo sapiens 45-48 19615253-7 2009 Cisplatin (DDP) resistance experiment was performed in SKOV3/DDP cells with RNAi. Cisplatin 0-9 translocase of inner mitochondrial membrane 8A Homo sapiens 61-64 18535748-1 2008 The effects of RNA interference-mediated insulin-like growth factor 1 receptor (IGF1R) gene silencing in response to cisplatin (DDP) in the lung cancer cell line A549 in vivo and in vitro were investigated using two plasmids expressing short hairpin RNA (shRNA) to IGF1R. Cisplatin 117-126 translocase of inner mitochondrial membrane 8A Homo sapiens 128-131 16086873-2 2005 Some researches on solid tumors show that cisplatin (DDP) have synergetic effect with VP-16. Cisplatin 42-51 translocase of inner mitochondrial membrane 8A Homo sapiens 53-56 18274296-1 2007 Cisplatin [cis-diamminedichloroplatinum(II) or cis-DDP], but not its stereoisomer transplatin, is suggested to be among the most powerful anticancer agents. Cisplatin 0-9 translocase of inner mitochondrial membrane 8A Homo sapiens 51-54 16640863-0 2006 [Study of bcl-2 antisense oligodeoxynucleotides on reversal of cisplatin resistance in ovarian cancer cell line A2780/DDP]. Cisplatin 63-72 translocase of inner mitochondrial membrane 8A Homo sapiens 118-121 16640863-1 2006 OBJECTIVE: To evaluate the influence of bcl-2 antisense oligodeoxynucleotides (AODN) on reversing cisplatin (DDP) resistance in ovarian carcinoma cell lines. Cisplatin 98-107 translocase of inner mitochondrial membrane 8A Homo sapiens 109-112 16640863-2 2006 METHODS: In the experiment groups, cisplatin resistant ovarian carcinoma cell line A2780/DDP cells were treated with cisplatin after oligodeoxynucleotides were transfected by lipofectamine. Cisplatin 35-44 translocase of inner mitochondrial membrane 8A Homo sapiens 89-92 16640863-2 2006 METHODS: In the experiment groups, cisplatin resistant ovarian carcinoma cell line A2780/DDP cells were treated with cisplatin after oligodeoxynucleotides were transfected by lipofectamine. Cisplatin 117-126 translocase of inner mitochondrial membrane 8A Homo sapiens 89-92 16354609-0 2005 [Expression of DNA transcription- and repair-related genes in cisplatin-resistant human ovarian carcinoma cell line COC1/DDP]. Cisplatin 62-71 translocase of inner mitochondrial membrane 8A Homo sapiens 121-124 16354609-2 2005 METHODS: The differential expression of DNA transcription- and repair-related genes between the parental COC1 and cisplatin-resistant COC1/DDP cell line was determined using cDNA microarray. Cisplatin 114-123 translocase of inner mitochondrial membrane 8A Homo sapiens 139-142 16354609-4 2005 Abnormality of DNA transcription and repair might be involved in the development of cisplatin resistance in COC1/DDP cells. Cisplatin 84-93 translocase of inner mitochondrial membrane 8A Homo sapiens 113-116 15498111-1 2004 In order to investigate the change of cell-cycle of K562 cells induced by cisplatin (DDP) and role of antisense oligonucleotide targeting Chk1/2 on apoptosis of K562 cell induced by DDP, the change of cell-cycle was observed by means of flow cytometry after different intervals in which the K562 cell were treated by DDP. Cisplatin 74-83 translocase of inner mitochondrial membrane 8A Homo sapiens 85-88 15863139-7 2005 RESULTS: Cisplatin decreased Xiap content and increased cytosolic HtrA2/Omi content and caspase-3 activity in cisplatin-sensitive ovarian cancer cell lines (A2780 and COC1), but not in the resistant variants (A2780/DDP and COC1/DDP). Cisplatin 9-18 translocase of inner mitochondrial membrane 8A Homo sapiens 215-218 15863139-7 2005 RESULTS: Cisplatin decreased Xiap content and increased cytosolic HtrA2/Omi content and caspase-3 activity in cisplatin-sensitive ovarian cancer cell lines (A2780 and COC1), but not in the resistant variants (A2780/DDP and COC1/DDP). Cisplatin 9-18 translocase of inner mitochondrial membrane 8A Homo sapiens 223-231 15547764-6 2004 The expressions of LRP in A2780/DDP and COC1/DDP cells were higher than those in A2780 and COC1 cells and conferred resistance to cisplatin. Cisplatin 130-139 translocase of inner mitochondrial membrane 8A Homo sapiens 45-48 15547764-10 2004 Efflux of cisplatin was greater from the nuclei of A2780/DDP and COC1/DDP cells than those of A2780 and COC1 cells, and was inhibited by anti-LRP monoclonal antibody. Cisplatin 10-19 translocase of inner mitochondrial membrane 8A Homo sapiens 57-60 15547764-10 2004 Efflux of cisplatin was greater from the nuclei of A2780/DDP and COC1/DDP cells than those of A2780 and COC1 cells, and was inhibited by anti-LRP monoclonal antibody. Cisplatin 10-19 translocase of inner mitochondrial membrane 8A Homo sapiens 70-73 12888918-1 2003 Our previous study demonstrated that the anticancer agent cis-diamminedichloroplatinum (II) (cis-DDP) inhibited the self-splicing activity of the Tetrahymena rRNA. Cisplatin 58-91 translocase of inner mitochondrial membrane 8A Homo sapiens 97-100 15156398-7 2004 Caspase-3 activity was reduced markedly and apoptotic ratios were significantly lower in A2780/DDP and COC1/DDP cells than in A2780 and COC1 cells after treatment with cisplatin. Cisplatin 168-177 translocase of inner mitochondrial membrane 8A Homo sapiens 95-98 15156398-7 2004 Caspase-3 activity was reduced markedly and apoptotic ratios were significantly lower in A2780/DDP and COC1/DDP cells than in A2780 and COC1 cells after treatment with cisplatin. Cisplatin 168-177 translocase of inner mitochondrial membrane 8A Homo sapiens 108-111 15315158-1 2004 To study the effects of cyclooxygenase 2 selective inhibitor Nimesulide (NIM) combined with Cisplatin (DDP) on human lung cancer and the possible mechanisms, the proliferation and apoptosis of human lung cancer cell line A549 were evaluated by MTT reduction assay and flow cytometry respectively. Cisplatin 92-101 translocase of inner mitochondrial membrane 8A Homo sapiens 103-106 15494695-1 2004 UNLABELLED: The AIM of the present study was to investigate DNA damage induced by widely applied anticancer preparation cisplatin (cis-DDP) at doses comparable with therapeutic ones in leukocytes of healthy donors. Cisplatin 120-129 translocase of inner mitochondrial membrane 8A Homo sapiens 135-138 21232215-1 2004 BACKGROUND: To study the effect and possible mechanism of cyclooxygenase-2 selective inhibitor, nimesulide (NIM), combined with cisplatin (DDP) on human lung cancer. Cisplatin 128-137 translocase of inner mitochondrial membrane 8A Homo sapiens 139-142 12520732-7 2002 The activity of caspase-3, the amount of PARP fragments, and apoptotic ratio in COC1/DDP reduced much more than COC1 did after treated with cisplatin. Cisplatin 140-149 translocase of inner mitochondrial membrane 8A Homo sapiens 85-88 12816691-1 2003 OBJECTIVE: To explore the role of apoptosis-associated genes and caspase-3 activity in cisplatin (DDP)-resistant human ovarian cancer cell lines. Cisplatin 87-96 translocase of inner mitochondrial membrane 8A Homo sapiens 98-101 12816691-3 2003 The apoptotic rates of A2780, COC1, A2780/DDP and COC1/DDP were measured with flow cytometry when treated with cisplatin. Cisplatin 111-120 translocase of inner mitochondrial membrane 8A Homo sapiens 55-58 11062745-1 2000 Paclitaxel (TAX) and cisplatin (DDP) rank among the most promising anti-neoplastic agents for the treatment of epithelial cancer. Cisplatin 21-30 translocase of inner mitochondrial membrane 8A Homo sapiens 32-35 12438251-1 2002 Impaired uptake of cisplatin (DDP) consistently accompanies the acquisition of resistance to the platinum drugs. Cisplatin 19-28 translocase of inner mitochondrial membrane 8A Homo sapiens 30-33 12667319-1 2002 OBJECTIVE: To study the toxic effect of toremifene (TOR) and its synergistic effect with cisplatin (DDP) on human lung adenocarcinoma cell line A549. Cisplatin 89-98 translocase of inner mitochondrial membrane 8A Homo sapiens 100-103 12667321-2 2002 METHODS: The expression of bcl-X(L) cisplatin treated cytochrome c and caspase-3 activity were monitored by RT-PCR and Western blot in cisplatin-resistant (A2780/DDP, COC1/DDP) and cisplatin-sensitive (A2780, COC1) cell lines. Cisplatin 135-144 translocase of inner mitochondrial membrane 8A Homo sapiens 162-165 12667321-2 2002 METHODS: The expression of bcl-X(L) cisplatin treated cytochrome c and caspase-3 activity were monitored by RT-PCR and Western blot in cisplatin-resistant (A2780/DDP, COC1/DDP) and cisplatin-sensitive (A2780, COC1) cell lines. Cisplatin 135-144 translocase of inner mitochondrial membrane 8A Homo sapiens 162-165 12667321-3 2002 The apoptotic rates of A2780, COC1, A2780/DDP and COC1/DDP were detected with flow cytometry after having been treated by cisplatin. Cisplatin 122-131 translocase of inner mitochondrial membrane 8A Homo sapiens 50-58 12270612-1 2002 Cisplatin (cis-DDP) is subject to nucleophilic displacement of chloride in water, forming aquated species, subsequently liberating hydrogen ion(s) with increasing pH. Cisplatin 0-9 translocase of inner mitochondrial membrane 8A Homo sapiens 15-18 11172601-1 2001 The object of this study was to determine how phosphatidylinositol (PI) signaling pathway is involved in the regulation of cisplatin (DDP) sensitivity. Cisplatin 123-132 translocase of inner mitochondrial membrane 8A Homo sapiens 134-137 12390742-5 2002 CONCLUSION: Mifepristone may act to enhance the sensitivity of COC1/DDP cells to cisplatin, possibly through regulating Bcl-2 and Bax protein expressions. Cisplatin 81-90 translocase of inner mitochondrial membrane 8A Homo sapiens 68-71 8758815-1 1996 OBJECTIVES: To investigate the enhanced impact of cyclosporin A (CsA) on antitumor activity of cisplatin (DDP) for human ovarian cancer cells. Cisplatin 95-104 translocase of inner mitochondrial membrane 8A Homo sapiens 106-109 9137537-0 1997 Establishment of a cisplatin-resistant gastric carcinoma cell line OCUM-2M/DDP. Cisplatin 19-28 translocase of inner mitochondrial membrane 8A Homo sapiens 75-78 9137537-1 1997 A cis-diamminedichloroplatinum (CDDP)-resistant scirrhous gastric cancer cell line, OCUM-2M/DDP, was established by chronic exposure of cells of the parent scirrhous gastric cancer cell line, OCUM-2M, to CDDP at progressively increasing concentrations. Cisplatin 2-30 translocase of inner mitochondrial membrane 8A Homo sapiens 33-36 9137537-9 1997 These findings suggest that the possible mechanisms of acquired resistance to CDDP in OCUM-2M/DDP cells may be a decrease in intracellular CDDP accumulation and detoxication by GSH. Cisplatin 139-143 translocase of inner mitochondrial membrane 8A Homo sapiens 79-82 9137537-10 1997 This OCUM-2M/DDP cell line could be used in further investigations of the mechanism of CDDP resistance in gastric cancer. Cisplatin 87-91 translocase of inner mitochondrial membrane 8A Homo sapiens 13-16 9275024-1 1997 Nine human ovarian cancer cell lines that express wild-type (wt) or mutated (mut) p53 were used to evaluate the cytotoxicity induced by cisplatin (DDP). Cisplatin 136-145 translocase of inner mitochondrial membrane 8A Homo sapiens 147-150 9016341-1 1997 The genetic mechanisms underlying cisplatin (DDP) resistance in yeast were investigated by examining the cytotoxicity of DDP to Schizosaccharomyces pombe mutants that were either hypersensitive or resistant to Cd. Cisplatin 34-43 translocase of inner mitochondrial membrane 8A Homo sapiens 45-48 9016341-1 1997 The genetic mechanisms underlying cisplatin (DDP) resistance in yeast were investigated by examining the cytotoxicity of DDP to Schizosaccharomyces pombe mutants that were either hypersensitive or resistant to Cd. Cisplatin 34-43 translocase of inner mitochondrial membrane 8A Homo sapiens 121-124 21594505-1 1996 Antitumor effect was compared between administration schedule of once a day dosing of cisplatin (DDP) for 2 consecutive days (q40d) with or without TNF alpha. Cisplatin 86-95 translocase of inner mitochondrial membrane 8A Homo sapiens 97-100 9275551-0 1996 [Establishment of human ovarian cancer cisplatin resistant cell line COC1/DDP and its mechanism of resistance]. Cisplatin 39-48 translocase of inner mitochondrial membrane 8A Homo sapiens 69-77 9275551-1 1996 OBJECTIVE: To establish cisplatin (DDP)-resistant subline of human ovarian cancer and investigate the mechanism responsible for resistance to DDP. Cisplatin 24-33 translocase of inner mitochondrial membrane 8A Homo sapiens 35-38 7883968-1 1995 Cross-resistance between cisplatin (DDP) and metalloid salts in human cells was sought on the basis that mechanisms that mediate metalloid salt cross-resistance in prokaryotes are evolutionarily conserved. Cisplatin 25-34 translocase of inner mitochondrial membrane 8A Homo sapiens 36-39 8525382-1 1995 The widely used antitumor drug cis-diamminedichloroplatinum(II) (cisplatin or cis-DDP) reacts with DNA, cross-linking two purine residues through the N7 atoms, which reside in the major groove in B-form DNA. Cisplatin 31-59 translocase of inner mitochondrial membrane 8A Homo sapiens 82-85 8525382-1 1995 The widely used antitumor drug cis-diamminedichloroplatinum(II) (cisplatin or cis-DDP) reacts with DNA, cross-linking two purine residues through the N7 atoms, which reside in the major groove in B-form DNA. Cisplatin 65-74 translocase of inner mitochondrial membrane 8A Homo sapiens 82-85 7911457-1 1994 The overt effects of the anti-cancer drugs cisplatin (cis-DDP) and taxol appear to be DNA modification and microtubule stabilization respectively, yet the mechanisms by which these drugs elicit tumor cell death are not well understood. Cisplatin 43-52 translocase of inner mitochondrial membrane 8A Homo sapiens 58-61 7987844-1 1994 The metal compound cisplatin (DDP) is a widely used anticancer agent but naturally occurring and acquired resistance to DDP limits its effectiveness. Cisplatin 19-28 translocase of inner mitochondrial membrane 8A Homo sapiens 30-33 7987844-1 1994 The metal compound cisplatin (DDP) is a widely used anticancer agent but naturally occurring and acquired resistance to DDP limits its effectiveness. Cisplatin 19-28 translocase of inner mitochondrial membrane 8A Homo sapiens 120-123 7981060-4 1994 GADD153 mRNA was increased in a transient, dose-dependent manner by cisplatin (DDP) when the tumour cells were grown both in vitro and as tumour xenografts in nude mice. Cisplatin 68-77 translocase of inner mitochondrial membrane 8A Homo sapiens 79-82 8080729-1 1994 The development of resistance to cisplatin (DDP) occurs rapidly both in vitro and in vivo, and constitutes a major obstacle to effective therapy. Cisplatin 33-42 translocase of inner mitochondrial membrane 8A Homo sapiens 44-47 18472761-0 1995 On the Mechanism of Action of the Antitumor Drug cis-Platin (cis-DDP) and its Second Generation Derivatives. Cisplatin 49-59 translocase of inner mitochondrial membrane 8A Homo sapiens 65-68 7977964-1 1994 BACKGROUND: Hypothesizing that cisplatin (DDP) drug resistance is dose dependent and the radiosensitizing effect of DDP is clinically beneficial, we conducted a chemoradiation protocol using extremely high doses of DDP delivered intra-arterially (IA) to locally advanced head and neck tumors. Cisplatin 31-40 translocase of inner mitochondrial membrane 8A Homo sapiens 42-45 7523882-0 1994 Induction of micronuclei and granular chromatin condensation in human skin fibroblasts influenced by cisplatin (cis-DDP) in vitro. Cisplatin 101-110 translocase of inner mitochondrial membrane 8A Homo sapiens 116-119 8057650-1 1994 A new combined cancer chemotherapy regimen of mitomycin C (MMC) and cisplatin (DDP) showed synergistic antitumor activity against human gastric cancer xenografts St-40 and SC-1-NU in BALB/c nu/nu mice. Cisplatin 68-77 translocase of inner mitochondrial membrane 8A Homo sapiens 79-82 1950544-1 1991 In a previous report we have characterized cisplatin (CDDP)-resistant sublines (HLac 79-DDP1 to DDP4) of the recloned squamous cell head and neck cancer (SCHNC) line HLac 79-ML revealing significant alterations of glutathione (GSH) metabolism and drug accumulation. Cisplatin 43-52 translocase of inner mitochondrial membrane 8A Homo sapiens 88-92 8120904-1 1994 DNase I has been used as an enzymatic probe to visualize the conformational alteration induced in DNA by the binding of either the antitumor drug cis-platinum (cis-DDP) or the therapeutically inactive derivatives, trans-platinum (trans-DDP) and chlorodiethylene-triamineplatinum(II) (dien-Pt). Cisplatin 146-158 translocase of inner mitochondrial membrane 8A Homo sapiens 164-167 8512589-1 1993 Killing of human ovarian carcinoma 2008 cells by cisplatin (DDP) is in direct proportion to the amount of drug entering the cell. Cisplatin 49-58 translocase of inner mitochondrial membrane 8A Homo sapiens 60-63 1619599-0 1992 Intrapleural administration of cisplatin (DDP) for treatment of pleural neoplasia. Cisplatin 31-40 translocase of inner mitochondrial membrane 8A Homo sapiens 42-45 1526199-1 1992 The treatment of cultured human cells by cis-diamminedichloroplatinum (II) (cis-DDP) has been shown to induce complex modifications in the cell cycle. Cisplatin 41-74 translocase of inner mitochondrial membrane 8A Homo sapiens 80-83 8172790-1 1994 PURPOSE: The purpose of the study was to assess the possible benefit of the combination vinorelbine (NVB)-cisplatin (DDP) in comparison with NVB alone in advanced non-small cell lung cancer (NSCLC), not treated previously. Cisplatin 106-115 translocase of inner mitochondrial membrane 8A Homo sapiens 117-120 1309303-1 1992 The authors prospectively evaluated the effects of three different schedules of cisplatin (DDP) administration in 60 patients with advanced epithelial ovarian cancer. Cisplatin 80-89 translocase of inner mitochondrial membrane 8A Homo sapiens 91-94 1796714-1 1991 The effect of cis-diamminedichloroplatinum (II) (cis-DDP) on the formation of interstrand cross-links in DNA and in DNA and chromatin complex from leukocytes was studied. Cisplatin 14-47 translocase of inner mitochondrial membrane 8A Homo sapiens 53-56 1950544-1 1991 In a previous report we have characterized cisplatin (CDDP)-resistant sublines (HLac 79-DDP1 to DDP4) of the recloned squamous cell head and neck cancer (SCHNC) line HLac 79-ML revealing significant alterations of glutathione (GSH) metabolism and drug accumulation. Cisplatin 54-58 translocase of inner mitochondrial membrane 8A Homo sapiens 88-92 2372473-1 1990 We have characterized the acquisition of resistance to cisplatin (DDP) in an in vivo solid tumor model. Cisplatin 55-64 translocase of inner mitochondrial membrane 8A Homo sapiens 66-69 2239803-1 1990 It has been suggested that the addition of weekly low-dose cisplatin (DDP) may potentiate the efficacy of continuous infusion 5-fluorouracil (5-FU) without adding significant toxicity. Cisplatin 59-68 translocase of inner mitochondrial membrane 8A Homo sapiens 70-73 2346318-0 1990 Resistance of in vitro grown IgM immunocytoma cells to cis-diamminedichloroplatinum (II) (cis-DDP) and cross-resistance to other DNA interacting drugs. Cisplatin 55-83 translocase of inner mitochondrial membrane 8A Homo sapiens 94-97 2346318-1 1990 Previously, we reported on the resistance to cis-diamminedichloroplatinum(II) (cis-DDP) of tumor cells in IgM immunocytoma tumors. Cisplatin 45-77 translocase of inner mitochondrial membrane 8A Homo sapiens 83-86 2284922-3 1990 The 50% inhibitory drug concentration (IC50) of CDDP as determined by the colorimetric MTT-assay was increased by the factors 2.7 (DDP1), 3.3 (DDP2), 5.1 (DDP3), and 6.4 (DDP4) in the respective sublines. Cisplatin 48-52 translocase of inner mitochondrial membrane 8A Homo sapiens 131-135 2225234-2 1990 Maintenance of low GSH levels during the 12-h interval after cisplatin (cis-DDP) treatment is critical. Cisplatin 61-70 translocase of inner mitochondrial membrane 8A Homo sapiens 76-79 34766543-1 2021 Cisplatin (DDP) is a first-line chemotherapeutic drug applied for the treatment of oral squamous cell carcinoma (OSCC). Cisplatin 0-9 translocase of inner mitochondrial membrane 8A Homo sapiens 11-14 2265371-0 1990 Randomized phase II study of a combination of cisplatin (DDP), 5-fluorouracil (5-FU), and allopurinol (HPP) versus 5-FU in advanced colorectal carcinoma. Cisplatin 46-55 translocase of inner mitochondrial membrane 8A Homo sapiens 57-60 2293559-1 1990 To study mechanisms underlying resistance to cis-diamminedichloroplatinum (II) (cis-DDP) we have induced resistance to this agent in BE human colon carcinoma cells. Cisplatin 45-78 translocase of inner mitochondrial membrane 8A Homo sapiens 84-87 34675987-2 2021 This study investigated the antitumor effects of cisplatin (DDP) combined with Sa (Sa/DDP) on the hepatic cancer cells (HCC), HepG2 and SMMC-7721. Cisplatin 49-58 translocase of inner mitochondrial membrane 8A Homo sapiens 60-63 2445485-1 1987 Cis-diamminedichloroplatinum (II) (cis-DDP) and its structural analogue cis-diamminediaquoplatinum(II) nitrate (cis-aq) were complexed via an intermediate dextran carrier to antibodies specifically reactive with B lymphoma cells (38C-13). Cisplatin 0-28 translocase of inner mitochondrial membrane 8A Homo sapiens 39-42 34923485-2 2021 In recent years, the development of cisplatin (DDP) resistance has become an important reason for the poor prognosis of OC patients. Cisplatin 36-45 translocase of inner mitochondrial membrane 8A Homo sapiens 47-50 35355712-3 2022 Cisplatin (DDP), a widely used anticancer agent for various types of cancers, also damages nontumor cells and tissues, which are mostly related to the activation of the inflammation pathway. Cisplatin 0-9 translocase of inner mitochondrial membrane 8A Homo sapiens 11-14 34328193-5 2021 Then, the cell viability of A549 cells with circ-PVT1-knockdown or -overexpression was detected after exposure to cisplatin (DDP). Cisplatin 114-123 translocase of inner mitochondrial membrane 8A Homo sapiens 125-128 34539881-4 2021 In this paper, we investigated the effects and mechanisms of bioactive hexapeptide (PGPIPN) derived in milk protein on the sensitivity of ovarian cancer cells to cis-dichlorodiammine platinum (DDP). Cisplatin 162-191 translocase of inner mitochondrial membrane 8A Homo sapiens 193-196 2766862-2 1989 A randomized clinical study of patients with advanced epithelial ovarian cancer after debulking surgery showed that high-dose (120 mg/m2) cis-platinum (DDP) in combination with cyclophosphamide (600 mg/m2) had a significantly higher response and survival rate than the low-dose DDP (60 mg/m2) and cyclophosphamide combination. Cisplatin 138-150 translocase of inner mitochondrial membrane 8A Homo sapiens 152-155 2766862-2 1989 A randomized clinical study of patients with advanced epithelial ovarian cancer after debulking surgery showed that high-dose (120 mg/m2) cis-platinum (DDP) in combination with cyclophosphamide (600 mg/m2) had a significantly higher response and survival rate than the low-dose DDP (60 mg/m2) and cyclophosphamide combination. Cisplatin 138-150 translocase of inner mitochondrial membrane 8A Homo sapiens 278-281 2785083-1 1989 Cis-platin (DDP) has proved to be highly active in the treatment of ovarian adenocarcinoma. Cisplatin 0-10 translocase of inner mitochondrial membrane 8A Homo sapiens 12-15 3051521-1 1988 A physiological pharmacokinetic model for the disposition of the antineoplastic drug cis-diamminedichloroplatinum(II) (cisplatin or DDP) in several mammalian species is reviewed. Cisplatin 85-117 translocase of inner mitochondrial membrane 8A Homo sapiens 132-135 3335000-1 1988 We have characterized the accumulation of cisplatin (DDP) into parent and cisplatin-resistant 2008 human ovarian carcinoma cells. Cisplatin 42-51 translocase of inner mitochondrial membrane 8A Homo sapiens 53-56 3335000-1 1988 We have characterized the accumulation of cisplatin (DDP) into parent and cisplatin-resistant 2008 human ovarian carcinoma cells. Cisplatin 74-83 translocase of inner mitochondrial membrane 8A Homo sapiens 53-56 3686682-1 1987 Twenty-two patients with advanced malignancies were treated with low-dose cytosine arabinoside (ara-C) (45 mg/m2 sc every 12 h for 3 days) and cisplatin (DDP) (100 mg/m2 ev on day 2, 2 h after ara-C. Cisplatin 143-152 translocase of inner mitochondrial membrane 8A Homo sapiens 154-157 3021314-2 1986 Ten consecutive adults with localized nonresectable hepatocellular carcinomas were selected as a nonrandom sample for an investigation into the effectiveness of cisplatin (DDP) as a single agent when administered regionally via the hepatic artery from 1981 to 1984. Cisplatin 161-170 translocase of inner mitochondrial membrane 8A Homo sapiens 172-175 3705194-0 1986 Cumulative or delayed nephrotoxicity after cisplatin (DDP) treatment. Cisplatin 43-52 translocase of inner mitochondrial membrane 8A Homo sapiens 54-57 3736675-2 1986 The main representative is cis-diamminedichloroplatinum (II) (cis-platin, DDP). Cisplatin 27-60 translocase of inner mitochondrial membrane 8A Homo sapiens 74-77 3705194-1 1986 The present retrospective study reports data regarding renal toxicity in 115 patients (63 males, 52 females; median age, 56 years) who received cumulative doses of cisplatin (DDP) greater than or equal to 200 mg/m2. Cisplatin 164-173 translocase of inner mitochondrial membrane 8A Homo sapiens 175-178 3717079-0 1986 Phase I study of thymidine (dThd) and cisplatin (DDP) given in combination. Cisplatin 38-47 translocase of inner mitochondrial membrane 8A Homo sapiens 49-52 3724190-0 1986 Etoposide (VP-16) plus cisplatin (DDP): a new active chemotherapeutic combination in patients with stage III-IV ovarian adenocarcinoma. Cisplatin 23-32 translocase of inner mitochondrial membrane 8A Homo sapiens 34-37 3724190-1 1986 Ten patients with Stage III-IV ovarian adenocarcinoma were treated with the drug combination etoposide (VP-16) plus cisplatin (DDP). Cisplatin 116-125 translocase of inner mitochondrial membrane 8A Homo sapiens 127-130 3712059-1 1986 A microscale synthesis of [13N]cisplatin (cis-dichlorodiammineplatinum(II), cis-DDP) from cyclotron-produced [13N]ammonia is presented. Cisplatin 31-40 translocase of inner mitochondrial membrane 8A Homo sapiens 80-83 3951788-1 1986 Cis-dichloro-trans-dihydroxy-bis(isopropylamine)platinum IV (CHIP) is a second-generation cis-platinum (DDP) derivative with an octahedral conformation of the platinum complex, far more water-soluble than DDP. Cisplatin 90-102 translocase of inner mitochondrial membrane 8A Homo sapiens 104-107 3744847-1 1986 Synchronously administered cis-platinum (cis-DDP) and radiation therapy have been used to treat unresectable squamous cell carcinomas of the head and neck. Cisplatin 27-39 translocase of inner mitochondrial membrane 8A Homo sapiens 45-48 3951788-1 1986 Cis-dichloro-trans-dihydroxy-bis(isopropylamine)platinum IV (CHIP) is a second-generation cis-platinum (DDP) derivative with an octahedral conformation of the platinum complex, far more water-soluble than DDP. Cisplatin 90-102 translocase of inner mitochondrial membrane 8A Homo sapiens 205-208 4085451-1 1985 cis-Diamminedichloroplatinum (II) (cis-DDP), the antitumor drug, is cytotoxic in vitro primarily by binding to DNA and disrupting its normal functions. Cisplatin 0-28 translocase of inner mitochondrial membrane 8A Homo sapiens 39-42 4041173-1 1985 Twenty-four (48%) out of a group of 50 patients treated with one to three single doses of cisplatin compound (cis-DDP), at a dosage of 60 mg/m2 body surface, were found to have deterioration of post-treatment pure tone audiometric threshold levels. Cisplatin 90-99 translocase of inner mitochondrial membrane 8A Homo sapiens 114-117 4039817-1 1985 The effective unwinding angle, phi, for cis-diamminedichloroplatinum(II) (cis-DDP) and trans-DDP was determined by utilizing high resolution gel electrophoresis and supercoiled phi X174 RF DNA as a substrate. Cisplatin 40-68 translocase of inner mitochondrial membrane 8A Homo sapiens 78-81 4039530-2 1985 Plasma platinum concentrations were measured in 45 patients receiving 46 courses of cisplatin (DDP) 100-120 mg/m2 and in 21 patients receiving 35-60 mg/m2. Cisplatin 84-93 translocase of inner mitochondrial membrane 8A Homo sapiens 95-98 7194728-1 1981 Twenty-seven consecutive patients with locally extensive or metastatic urothelial cancer, primarily bladder, were given cis-diamminedichloroplatinum (II) (DDP) at a dose of 70 mg/m2 every three weeks. Cisplatin 120-153 translocase of inner mitochondrial membrane 8A Homo sapiens 155-158 6539245-2 1984 Electrochemical activities of cis-dichlorodiammineplatinum (II) (cis-DDP) and its trans isomer were studied by classical and differential pulse polarography (d.p.p.). Cisplatin 30-63 translocase of inner mitochondrial membrane 8A Homo sapiens 69-72 6347356-2 1983 A prospective multi-institutional randomized trial compared the use of cisplatin (DDP) alone to the combination of DDP and cyclophosphamide in patients with advanced urothelial cancer. Cisplatin 71-80 translocase of inner mitochondrial membrane 8A Homo sapiens 82-85 6891601-1 1982 The cancer chemotherapeutic drug cis-diamminedichloroplatinum (II) (cis-DDP) was reacted with deoxyribonucleosides, and the products were separated by high-pressure liquid chromatography and characterized by 1H nuclear magnetic resonance. Cisplatin 33-66 translocase of inner mitochondrial membrane 8A Homo sapiens 72-75 3885173-4 1985 The addition of cisplatin (DDP) to cyclophosphamide and doxorubicin (Adriamycin) resulted in major response rates that were superior to those obtained with cyclophosphamide or doxorubicin used alone or in combination. Cisplatin 16-25 translocase of inner mitochondrial membrane 8A Homo sapiens 27-30 6192802-1 1983 A case of a bulky primary extragonadal seminoma which was treated initially with chemotherapy consisting of cis-diamminedichloroplatinum (cis-DDP) and vinblastine is reported. Cisplatin 108-136 translocase of inner mitochondrial membrane 8A Homo sapiens 142-145 75760-1 1978 Patients with unresectable, previously untreated head and neck cancer were given cis-diamminedichloroplatinum (II) (DDP), 3 mg/kg, with mannitol diuresis (day 1), followed by a continuous infusion of bleomycin, 0.25 mg/kg/day, days 3 through 10, after an initial loading dose of 0.25 mg/kg by rapid IV injection on day 3. Cisplatin 81-109 translocase of inner mitochondrial membrane 8A Homo sapiens 116-119 121143-2 1979 Platinum coordination complexes represent a new class of antineoplastic agents among which only cis-diamminedichloroplatinum(II) (cis-DDP) has undergone extensive clinical trials. Cisplatin 96-127 translocase of inner mitochondrial membrane 8A Homo sapiens 134-137 33737087-3 2021 Cisplatin (DDP) has been used and studied as the first-line agent for breast cancer (BC) treatment. Cisplatin 0-9 translocase of inner mitochondrial membrane 8A Homo sapiens 11-14 33968209-1 2021 Long non-coding RNA homeobox A11-antisense RNA (HOXA11-AS) has been implicated in cisplatin (DDP) resistance in multiple types of cancer. Cisplatin 82-91 translocase of inner mitochondrial membrane 8A Homo sapiens 93-96 33520990-1 2020 Cisplatin (DDP) is the first-line chemotherapeutic agent against lung cancer. Cisplatin 0-9 translocase of inner mitochondrial membrane 8A Homo sapiens 11-14 32782152-4 2020 The CDDP-resistant SBC-3/DDP and A549/DDP cells were established through continuous treatment with a gradually increasing dose of CDDP. Cisplatin 4-8 translocase of inner mitochondrial membrane 8A Homo sapiens 25-28 32782152-4 2020 The CDDP-resistant SBC-3/DDP and A549/DDP cells were established through continuous treatment with a gradually increasing dose of CDDP. Cisplatin 130-134 translocase of inner mitochondrial membrane 8A Homo sapiens 5-8 32782152-4 2020 The CDDP-resistant SBC-3/DDP and A549/DDP cells were established through continuous treatment with a gradually increasing dose of CDDP. Cisplatin 130-134 translocase of inner mitochondrial membrane 8A Homo sapiens 25-28 32782152-5 2020 The viability of SBC-3/DDP and A549/DDP cells treated with CDDP was 3.68 and 2.08 times higher than that of the respective parental cells. Cisplatin 59-63 translocase of inner mitochondrial membrane 8A Homo sapiens 23-26 32782152-5 2020 The viability of SBC-3/DDP and A549/DDP cells treated with CDDP was 3.68 and 2.08 times higher than that of the respective parental cells. Cisplatin 59-63 translocase of inner mitochondrial membrane 8A Homo sapiens 36-39 32782152-8 2020 In addition, co-treatment with CDDP and sulfasalazine, an xCT inhibitor, showed lower the concentration of 50% inhibition for cell viability than CDDP alone in SBC-3 and SBC-3/DDP cells, but not in A549 and A549/DDP cells. Cisplatin 31-35 translocase of inner mitochondrial membrane 8A Homo sapiens 147-150 32782152-8 2020 In addition, co-treatment with CDDP and sulfasalazine, an xCT inhibitor, showed lower the concentration of 50% inhibition for cell viability than CDDP alone in SBC-3 and SBC-3/DDP cells, but not in A549 and A549/DDP cells. Cisplatin 146-150 translocase of inner mitochondrial membrane 8A Homo sapiens 32-35 32124583-2 2020 However, there was a lack of understanding of the mechanism by which CCAT1 conferred cisplatin (also known as DDP) resistance in ovarian cancer cells. Cisplatin 85-94 translocase of inner mitochondrial membrane 8A Homo sapiens 110-113 32124583-3 2020 Materials and Methods: Cell viability of A2780, SKOV3, A2780/DDP and SKOV3/DDP cells upon cisplatin treatment was monitored by MTT assay. Cisplatin 90-99 translocase of inner mitochondrial membrane 8A Homo sapiens 75-78 32124583-9 2020 Results: CCAT1 was highly expressed in cisplatin-resistant ovarian cancer cell line A2780/DDP and SKOV3/DDP. Cisplatin 39-48 translocase of inner mitochondrial membrane 8A Homo sapiens 90-93 32217144-2 2020 Cisplatin (cis-diamminedichloroplatinum II, DDP) is the first line of chemotherapeutic drug widely used in clinic for ESCC patients. Cisplatin 0-9 translocase of inner mitochondrial membrane 8A Homo sapiens 44-47 31402373-4 2019 To do so, we prepared biocompatible lipid-coated CaO2/cisplatin nanoparticles (LipoCaO2/DDP) by the reverse microemulsion method. Cisplatin 54-63 translocase of inner mitochondrial membrane 8A Homo sapiens 79-91 32010312-1 2020 The present study aimed to investigate the regulatory mechanisms by which interleukin (IL)-22 regulates cisplatin (DDP) sensitivity in osteosarcoma cells. Cisplatin 104-113 translocase of inner mitochondrial membrane 8A Homo sapiens 115-118 31647948-2 2019 Our present study aimed to investigate the role and molecular mechanism of circ_0076305 in regulating cisplatin (DDP) resistance of non-small cell lung cancer (NSCLC). Cisplatin 102-111 translocase of inner mitochondrial membrane 8A Homo sapiens 113-116 31402373-6 2019 In vitro experiments showed that LipoCaO2/DDP could deplete GSH for preventing the binding of GSH to cisplatin. Cisplatin 101-110 translocase of inner mitochondrial membrane 8A Homo sapiens 42-45 29512779-4 2018 Cisplatin (DDP) is a commonly used drug that can control carcinoma progression, although its mechanisms are poorly understood. Cisplatin 0-9 translocase of inner mitochondrial membrane 8A Homo sapiens 11-14 30843262-9 2019 MiR-876-3p inhibited drug resistance of cisplatin-resistant cell line SGC-7901/DDP and MKN-45/DDP, as shown by decreased cell viability, IC50 , and colony formation ability. Cisplatin 40-49 translocase of inner mitochondrial membrane 8A Homo sapiens 79-82 30843262-9 2019 MiR-876-3p inhibited drug resistance of cisplatin-resistant cell line SGC-7901/DDP and MKN-45/DDP, as shown by decreased cell viability, IC50 , and colony formation ability. Cisplatin 40-49 translocase of inner mitochondrial membrane 8A Homo sapiens 87-97 31373204-2 2019 Drug-sensitive A549 cells and cisplatin-resistant A549/DDP cells were used to explore the potential metabolic pathways and key targets associated with cisplatin resistance by integrating untargeted metabolomics with transcriptomics. Cisplatin 30-39 translocase of inner mitochondrial membrane 8A Homo sapiens 55-58 31373204-2 2019 Drug-sensitive A549 cells and cisplatin-resistant A549/DDP cells were used to explore the potential metabolic pathways and key targets associated with cisplatin resistance by integrating untargeted metabolomics with transcriptomics. Cisplatin 151-160 translocase of inner mitochondrial membrane 8A Homo sapiens 55-58 31373204-4 2019 The results of comprehensive analyses showed that 19 metabolites were significantly changed in A549/DDP versus A549 cells, and some pathways had a close relationship with cisplatin resistance, such as the biosynthesis of aminoacyl-tRNA, glycerophospholipid metabolism, and glutathione metabolism. Cisplatin 171-180 translocase of inner mitochondrial membrane 8A Homo sapiens 100-103 31319879-2 2019 Cisplatin (DDP) is known as an effective chemotherapeutic agent against cancer by inducing DNA damage and cell apoptosis. Cisplatin 0-9 translocase of inner mitochondrial membrane 8A Homo sapiens 11-14 31028999-2 2019 However, the molecular mechanism by which lncRNA regulates cisplatin (DDP) in triple-negative breast cancer (TNBC) remains unclear. Cisplatin 59-68 translocase of inner mitochondrial membrane 8A Homo sapiens 70-73 30015875-4 2018 The experiments using genetically matched ovarian cancer cell lines SKOV3 (cisplatin-sensitive) and SKOV3/DDP (cisplatin-resistant) in the present study provided some important findings. Cisplatin 111-120 translocase of inner mitochondrial membrane 8A Homo sapiens 100-109 30015875-9 2018 Furthermore, the inhibition of Bcl-2 reduced the OXPHOS and sensitivity of SKOV3/DDP cells to cisplatin in a selective manner. Cisplatin 94-103 translocase of inner mitochondrial membrane 8A Homo sapiens 81-84 30172262-4 2018 METHODS: Metabolites were extracted from A549 cells and cisplatin resistant A549/DDP cells, and ultraperformance liquid chromatography coupled with time of flight mass spectrometry was used to perform metabolomic analysis of endogenous molecules of the two cells and obtain metabolic differences. Cisplatin 56-65 translocase of inner mitochondrial membrane 8A Homo sapiens 81-84 30070323-1 2018 OBJECTIVE: To investigate the role of long non-coding ribonucleic acid (lncRNA) nicotinamide nucleotide transhydrogenase-antisense RNA1 (NNT-AS1) in cisplatin (DDP) resistance in non-small cell lung cancer (NSCLC) and its molecular mechanism. Cisplatin 149-158 translocase of inner mitochondrial membrane 8A Homo sapiens 160-163 30675218-4 2019 The present study observed that in ovarian cancer cells, the expression of ABCG2 was significantly upregulated in response to cis-diamminedichloroplatinum (cisplatin/DDP) treatment, in addition the expression of NOS1 exhibited an increasing trend. Cisplatin 126-154 translocase of inner mitochondrial membrane 8A Homo sapiens 166-169 30675218-4 2019 The present study observed that in ovarian cancer cells, the expression of ABCG2 was significantly upregulated in response to cis-diamminedichloroplatinum (cisplatin/DDP) treatment, in addition the expression of NOS1 exhibited an increasing trend. Cisplatin 156-165 translocase of inner mitochondrial membrane 8A Homo sapiens 166-169 30655852-1 2019 Cisplatin (DDP)-based anticancer therapy is an important chemotherapeutic strategy for the treatment of colorectal cancer. Cisplatin 0-9 translocase of inner mitochondrial membrane 8A Homo sapiens 11-14 29635130-1 2018 5-Fluorouracil (5-Fu) and cisplatin (DDP) as important therapies in treatment of human gastric cancer have been widely determined. Cisplatin 26-35 translocase of inner mitochondrial membrane 8A Homo sapiens 37-40 28686971-0 2017 GAS5 knockdown reduces the chemo-sensitivity of non-small cell lung cancer (NSCLC) cell to cisplatin (DDP) through regulating miR-21/PTEN axis. Cisplatin 91-100 translocase of inner mitochondrial membrane 8A Homo sapiens 102-105 29197940-3 2018 AIMS: To explore the chemosensitive effect and mechanism of TQ in augmentation of cisplatin (DDP)-induced apoptosis of EC, both in vitro and in vivo. Cisplatin 82-91 translocase of inner mitochondrial membrane 8A Homo sapiens 93-96 28686971-2 2017 The NSCLC chemo-resistance to cisplatin (DDP) -based chemotherapy remains a huge challenge. Cisplatin 30-39 translocase of inner mitochondrial membrane 8A Homo sapiens 41-44 28771580-1 2017 BACKGROUND AND OBJECTIVE: Chemotherapy drugs, such as cisplatin (DDP), improve the survival of patients with lung cancer by inducing apoptosis in cancer cells, which quickly develop resistance to DDP through uncharacterized mechanisms. Cisplatin 54-63 translocase of inner mitochondrial membrane 8A Homo sapiens 65-68 28771580-1 2017 BACKGROUND AND OBJECTIVE: Chemotherapy drugs, such as cisplatin (DDP), improve the survival of patients with lung cancer by inducing apoptosis in cancer cells, which quickly develop resistance to DDP through uncharacterized mechanisms. Cisplatin 54-63 translocase of inner mitochondrial membrane 8A Homo sapiens 196-199 28771580-10 2017 CONCLUSION: In this study, we demonstrated for the first time that GLIPR1 could modulate the response of DDP-resistant A549/DDP and H460/DDP cells to cisplatin. Cisplatin 150-159 translocase of inner mitochondrial membrane 8A Homo sapiens 105-108 28771580-10 2017 CONCLUSION: In this study, we demonstrated for the first time that GLIPR1 could modulate the response of DDP-resistant A549/DDP and H460/DDP cells to cisplatin. Cisplatin 150-159 translocase of inner mitochondrial membrane 8A Homo sapiens 124-127 28771580-10 2017 CONCLUSION: In this study, we demonstrated for the first time that GLIPR1 could modulate the response of DDP-resistant A549/DDP and H460/DDP cells to cisplatin. Cisplatin 150-159 translocase of inner mitochondrial membrane 8A Homo sapiens 124-127 28781688-1 2017 Gastric cancer is the third most frequent cause of cancer-associated mortality and almost all patients who respond initially to cisplatin (DDP) later develop drug resistance, indicating multi-drug resistance (MDR) is an essential aspect of the failure of treatment. Cisplatin 128-137 translocase of inner mitochondrial membrane 8A Homo sapiens 139-142 27813328-0 2017 Depleted aldehyde dehydrogenase 1A1 (ALDH1A1) reverses cisplatin resistance of human lung adenocarcinoma cell A549/DDP. Cisplatin 55-64 translocase of inner mitochondrial membrane 8A Homo sapiens 115-118 28532536-5 2017 METHODS: The cisplatin-resistance lung cancer cell line A549/DDP was constructed by induction method in vitro, and cisplatin-resistance detected by CCK8 assay. Cisplatin 13-22 translocase of inner mitochondrial membrane 8A Homo sapiens 61-64 28532536-5 2017 METHODS: The cisplatin-resistance lung cancer cell line A549/DDP was constructed by induction method in vitro, and cisplatin-resistance detected by CCK8 assay. Cisplatin 115-124 translocase of inner mitochondrial membrane 8A Homo sapiens 61-64 28532536-8 2017 A549/DDP were knockdown of SOX4 by siRNA transfection, and the cisplatin-resistance of detected by CCK-8 assay, the expression level of beta-catenin and Survivin were detected by real-time PCR and Western blot. Cisplatin 63-72 translocase of inner mitochondrial membrane 8A Homo sapiens 5-8 28532536-9 2017 RESULTS: The cisplatin-resistance cell line A549/DDP was constructed successfully, and its cisplatin-resistance is 13.7 times higher than in A549. Cisplatin 13-22 translocase of inner mitochondrial membrane 8A Homo sapiens 49-52 28532536-9 2017 RESULTS: The cisplatin-resistance cell line A549/DDP was constructed successfully, and its cisplatin-resistance is 13.7 times higher than in A549. Cisplatin 91-100 translocase of inner mitochondrial membrane 8A Homo sapiens 49-52 28532536-12 2017 The cisplatin-resistance significantly decreased in A549/DDP cells after knockdown of SOX4 by siRNA transfection. Cisplatin 4-13 translocase of inner mitochondrial membrane 8A Homo sapiens 57-60 27922681-6 2017 Cisplatin-resistant NSCLC cells A549/DDP and its parental A549 cells were employed in this study. Cisplatin 0-9 translocase of inner mitochondrial membrane 8A Homo sapiens 37-40 28968986-3 2017 The CD-DST was performed to detect the sensitivity of tumor cells to gemcitabine and cis-diamminedichloridoplatinum (II) (cisplatin, DDP). Cisplatin 85-120 translocase of inner mitochondrial membrane 8A Homo sapiens 133-136 28553110-1 2017 Exosomes derived from lung cancer cells confer cisplatin (DDP) resistance to other cancer cells. Cisplatin 47-56 translocase of inner mitochondrial membrane 8A Homo sapiens 58-61 27878245-0 2017 Baicalin attenuates DDP (cisplatin) resistance in lung cancer by downregulating MARK2 and p-Akt. Cisplatin 25-34 translocase of inner mitochondrial membrane 8A Homo sapiens 20-23 27878245-1 2017 DDP (cisplatin) resistance in lung cancer has been widely reported. Cisplatin 5-14 translocase of inner mitochondrial membrane 8A Homo sapiens 0-3 27813328-9 2017 RESULTS: ALDH1A1 is overexpressed in cisplatin resistant cell line A549/DDP, compared with A549. Cisplatin 37-46 translocase of inner mitochondrial membrane 8A Homo sapiens 72-75 27813328-13 2017 CONCLUSION: These results suggest that ALDH1A1 depletion could reverse cisplatin resistance in human lung cancer cell line A549/DDP, and may act as a potential target for the treatment of lung cancers resistant to cisplatin. Cisplatin 71-80 translocase of inner mitochondrial membrane 8A Homo sapiens 128-131 27877224-1 2016 Purpose: Platinum derivatives, such as cisplatin (DDP), carboplatin and oxaliplatin, are widely used components of modern cancer chemotherapy including esophageal squamous cell cancer (ESCC). Cisplatin 39-48 translocase of inner mitochondrial membrane 8A Homo sapiens 50-53 27995666-2 2016 In this study, the major purpose was to assess the expression and methylation levels of ABCB1 in human lung adenocarcinoma and to reveal the relationship between these processes and acquisition of cisplatin (DDP) resistance in the human cancer cell line A549. Cisplatin 197-206 translocase of inner mitochondrial membrane 8A Homo sapiens 208-211 27995666-5 2016 Our results showed that the onset of resistance to the cisplatin analogue, DDP, was associated with hypermethylation of the ABCB1 gene. Cisplatin 55-64 translocase of inner mitochondrial membrane 8A Homo sapiens 75-78 27392028-12 2016 In conclusion, Galectin-1 gene silencing would improve the sensitivity of A549/DDP cells to cisplatin in vivo and in vitro. Cisplatin 92-101 translocase of inner mitochondrial membrane 8A Homo sapiens 74-82 26794135-2 2016 The present study aimed to verify the relationship between MACC1 and cisplatin resistance in ovarian cancer cells and the possible mechanisms, which was implemented by inhibition of the expression of MACC1 in cisplatin-resistant human ovarian cancer cell lines A2780/DDP and COC1/DDP. Cisplatin 69-78 translocase of inner mitochondrial membrane 8A Homo sapiens 267-270 27383136-3 2016 We used cisplatin-sensitive A549 cells and cisplatin-resistant A549/DDP cells as cell models with IC50 of 11.58 and 46.95 muM, respectively. Cisplatin 43-52 translocase of inner mitochondrial membrane 8A Homo sapiens 68-71 27383136-5 2016 Interestingly, with the increasing concentration of DDP, HMGB1 was gradually located into cytoplasm in cisplatin-sensitive A549 cells. Cisplatin 103-112 translocase of inner mitochondrial membrane 8A Homo sapiens 52-55 27484796-4 2016 Cisplatin, also known as cis-diamminedichloroplatinum or DDP, is a standard chemotherapeutic agent used to treat prostate cancer; however, it has the disadvantage of various serious side effects. Cisplatin 0-9 translocase of inner mitochondrial membrane 8A Homo sapiens 57-60 27484796-4 2016 Cisplatin, also known as cis-diamminedichloroplatinum or DDP, is a standard chemotherapeutic agent used to treat prostate cancer; however, it has the disadvantage of various serious side effects. Cisplatin 25-53 translocase of inner mitochondrial membrane 8A Homo sapiens 57-60 27093515-1 2016 The nephrotoxicity of cisplatin (cis-DDP) limits its general clinical applications. Cisplatin 22-31 translocase of inner mitochondrial membrane 8A Homo sapiens 37-40 26794135-2 2016 The present study aimed to verify the relationship between MACC1 and cisplatin resistance in ovarian cancer cells and the possible mechanisms, which was implemented by inhibition of the expression of MACC1 in cisplatin-resistant human ovarian cancer cell lines A2780/DDP and COC1/DDP. Cisplatin 69-78 translocase of inner mitochondrial membrane 8A Homo sapiens 275-283 26794135-2 2016 The present study aimed to verify the relationship between MACC1 and cisplatin resistance in ovarian cancer cells and the possible mechanisms, which was implemented by inhibition of the expression of MACC1 in cisplatin-resistant human ovarian cancer cell lines A2780/DDP and COC1/DDP. Cisplatin 209-218 translocase of inner mitochondrial membrane 8A Homo sapiens 267-270 26794135-2 2016 The present study aimed to verify the relationship between MACC1 and cisplatin resistance in ovarian cancer cells and the possible mechanisms, which was implemented by inhibition of the expression of MACC1 in cisplatin-resistant human ovarian cancer cell lines A2780/DDP and COC1/DDP. Cisplatin 209-218 translocase of inner mitochondrial membrane 8A Homo sapiens 275-283 25640351-5 2015 before and after treatment with cisplatin (DDP). Cisplatin 32-41 translocase of inner mitochondrial membrane 8A Homo sapiens 43-46 26655271-1 2016 Cisplatin (diamminedichloroplatinum, DDP) is widely used as the first-line treatment for patients with unresectable or no metastatic cancer. Cisplatin 0-9 translocase of inner mitochondrial membrane 8A Homo sapiens 37-40 26517090-3 2015 The aim of this study was to elucidate the function of the miR-222-ABCG2 pathway in the correlation between cisplatin (DDP) resistance and enhanced cell migration/invasion in tongue squamous cell carcinoma (TSCC). Cisplatin 108-117 translocase of inner mitochondrial membrane 8A Homo sapiens 119-122 25923669-2 2015 Cisplatin (DDP)-based chemotherapy is an important part of multimodal treatments. Cisplatin 0-9 translocase of inner mitochondrial membrane 8A Homo sapiens 11-14 25663864-3 2015 Chemotherapeutic agents such as cisplatin (DDP) are considered as first-line treatment for cervical carcinoma. Cisplatin 32-41 translocase of inner mitochondrial membrane 8A Homo sapiens 43-46 25204523-0 2015 Multifunctional polyamidoamine-modified selenium nanoparticles dual-delivering siRNA and cisplatin to A549/DDP cells for reversal multidrug resistance. Cisplatin 89-98 translocase of inner mitochondrial membrane 8A Homo sapiens 107-110 26919245-7 2016 Furthermore, overexpression of ISG15 increased NPC cell resistance to radiation and cisplatin (DDP) treatment. Cisplatin 84-93 translocase of inner mitochondrial membrane 8A Homo sapiens 95-98 26722293-0 2015 The role and mechanism of WEE1 on the cisplatin resistance reversal of the HepG2/DDP human hepatic cancer cell line. Cisplatin 38-47 translocase of inner mitochondrial membrane 8A Homo sapiens 81-84 26722293-5 2015 It was demonstrated that silencing WEE1 expression resulted in an increased cisplatin sensitivity of HepG2/DDP, in addition to an increased rate of apoptosis and intracellular concentration of rhodamine 123. Cisplatin 76-85 translocase of inner mitochondrial membrane 8A Homo sapiens 107-110 25364436-3 2014 A cisplatin (DDP)-resistant human ovarian cancer cell line, SKOV3/DDP, was screened, validated and injected subcutaneously into the neck of female nude mice. Cisplatin 2-11 translocase of inner mitochondrial membrane 8A Homo sapiens 13-16 25364470-1 2014 Although cisplatin (DDP) has been reported to be a promising antitumor therapy for non-small cell lung cancer (NSCLC), the effectiveness of the treatment remains limited due to an inherent tumor resistance to DDP. Cisplatin 9-18 translocase of inner mitochondrial membrane 8A Homo sapiens 20-23 25364436-3 2014 A cisplatin (DDP)-resistant human ovarian cancer cell line, SKOV3/DDP, was screened, validated and injected subcutaneously into the neck of female nude mice. Cisplatin 2-11 translocase of inner mitochondrial membrane 8A Homo sapiens 66-69 25364470-1 2014 Although cisplatin (DDP) has been reported to be a promising antitumor therapy for non-small cell lung cancer (NSCLC), the effectiveness of the treatment remains limited due to an inherent tumor resistance to DDP. Cisplatin 9-18 translocase of inner mitochondrial membrane 8A Homo sapiens 209-212 24581167-0 2014 [The effect and mechanism of vinorelbine on cisplatin resistance of human lung cancer cell line A549/DDP]. Cisplatin 44-53 translocase of inner mitochondrial membrane 8A Homo sapiens 101-104 24940482-1 2014 Cisplatin [cis-diammineplatinum dichloride (DDP)] resistance is a major limitation in the treatment of lung cancer. Cisplatin 0-9 translocase of inner mitochondrial membrane 8A Homo sapiens 44-47 24699918-1 2014 The present study examined the effects of cisplatin (DDP) on gastric carcinoma cells by inhibiting the expression of excision repair cross-complementing 1 (ERCC1) using RNA interference (RNAi). Cisplatin 42-51 translocase of inner mitochondrial membrane 8A Homo sapiens 53-56 24699858-2 2014 The aim of this study was to identify candidate DNA methylation drivers of cisplatin (DDP) resistance in non-small cell lung cancer (NSCLC). Cisplatin 75-84 translocase of inner mitochondrial membrane 8A Homo sapiens 86-89 24854552-0 2014 [Expression and significance of IKBKB in pulmonary adenocarcinoma A549 cells and its cisplatin-resistant variant A549/DDP]. Cisplatin 85-94 translocase of inner mitochondrial membrane 8A Homo sapiens 118-121 24854552-5 2014 The aim of this study is to investigate the differential expression of IKBKB gene in human lung adenocarcinoma cells line A549 and the cisplatin-resistant variant A549/DDP and the mechanisms of cisplain-resistance induced by IKBKB gene. Cisplatin 135-144 translocase of inner mitochondrial membrane 8A Homo sapiens 168-171 24099915-2 2014 However, the possible role of miR-31 in cisplatin (DDP) resistance in non-small cell lung cancer (NSCLC) remains unclear. Cisplatin 40-49 translocase of inner mitochondrial membrane 8A Homo sapiens 51-54 24586853-3 2014 This study was conducted to determine the involvement of exosomes in the regulation of sensitivity of the lung cancer cell line A549 to cisplatin (DDP). Cisplatin 136-145 translocase of inner mitochondrial membrane 8A Homo sapiens 147-150 24581167-6 2014 CONCLUSION: Vinorelbine treatment led to increase of cisplatin sensitivity of A549/DDP cells and the mechanisms included the regulation of PTEN/AKT/NF-kappaB signal pathway to decreased drug resistance gene expression and increased pro-apoptosis gene expression. Cisplatin 53-62 translocase of inner mitochondrial membrane 8A Homo sapiens 83-86 24935589-3 2014 This study aimed to investigate the effects of cisplatin combined with metformin on the proliferation, invasion and migration of HNE1/DDP human nasopharyngeal carcinoma (NPC) cells, and to provide a new target for treating metastasis. Cisplatin 47-56 translocase of inner mitochondrial membrane 8A Homo sapiens 134-137 23588667-6 2013 Knockdown of MBD1 significantly increased the sensitivity of cells to radiation and cisplatin (diamindichloridoplatin, DDP) in vitro. Cisplatin 84-93 translocase of inner mitochondrial membrane 8A Homo sapiens 119-122 24173500-1 2014 Radiotherapy and adjuvant cisplatin (DDP) chemotherapy are standard approaches used in the treatment of nasopharyngeal carcinoma (NPC). Cisplatin 26-35 translocase of inner mitochondrial membrane 8A Homo sapiens 37-40 25276252-3 2014 AIM: To study the effect of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) combined with chemotherapeutic drug cisplatin (DDP) on the expression of multidrug resistance gene 1 (MDR1) in the gastric cancer cell line SGC-7901/VCR. Cisplatin 129-138 translocase of inner mitochondrial membrane 8A Homo sapiens 140-143 24606472-1 2014 AIM: To investigate the mechanisms of induction of apoptosis of esophageal cancer cells by esophageal cancer-related gene 2 (ECRG2) in combination with cisplatin (DDP). Cisplatin 152-161 translocase of inner mitochondrial membrane 8A Homo sapiens 163-166 24405596-1 2014 OBJECTIVE: To investigate the inhibitory effects of recombinant human interleukin-24 (rhIL-24) on ovarian cancer cell lines SKOV3 and cisplatin (DDP)-resistant ovarian cancer cell lines SKOV3/DDP in vitro, and to observe the changes in apoptosis and cell cycle of SKOV3 and SKOV3/DDP. Cisplatin 134-143 translocase of inner mitochondrial membrane 8A Homo sapiens 145-148 23904379-5 2013 This study was to investigate whether miR-106a mediated resistance of the ovarian cancer cell line A2780 to the chemotherapeutic agent cisplatin (DDP). Cisplatin 135-144 translocase of inner mitochondrial membrane 8A Homo sapiens 146-149 23904379-9 2013 As compared to A2780 cells, the expression of miR-106a was down-regulated in the cisplatin resistant cell line A2780/DDP. Cisplatin 81-90 translocase of inner mitochondrial membrane 8A Homo sapiens 117-120 23412924-3 2013 Upregulation of miR-34c to enhance the chemotherapeutic effect of cisplatin (DDP) has not been studied in human endometrial cancer cells before. Cisplatin 66-75 translocase of inner mitochondrial membrane 8A Homo sapiens 77-80 22941407-3 2012 The human esophageal squamous carcinoma cisplatin-resistant cell line YES-2/DDP was isolated by stepwise selection in increasing concentrations of cisplatin. Cisplatin 147-156 translocase of inner mitochondrial membrane 8A Homo sapiens 76-79 22941407-3 2012 The human esophageal squamous carcinoma cisplatin-resistant cell line YES-2/DDP was isolated by stepwise selection in increasing concentrations of cisplatin. Cisplatin 40-49 translocase of inner mitochondrial membrane 8A Homo sapiens 76-79 22941407-7 2012 The resulting cell line YES-2/DDP was 16.4-fold resistant to cisplatin, the cytotoxicity of cisplatin to YES-2/DDP cells was enhanced by TET in a dose-dependent manner. Cisplatin 61-70 translocase of inner mitochondrial membrane 8A Homo sapiens 30-33 22941407-7 2012 The resulting cell line YES-2/DDP was 16.4-fold resistant to cisplatin, the cytotoxicity of cisplatin to YES-2/DDP cells was enhanced by TET in a dose-dependent manner. Cisplatin 92-101 translocase of inner mitochondrial membrane 8A Homo sapiens 30-33 22941407-7 2012 The resulting cell line YES-2/DDP was 16.4-fold resistant to cisplatin, the cytotoxicity of cisplatin to YES-2/DDP cells was enhanced by TET in a dose-dependent manner. Cisplatin 92-101 translocase of inner mitochondrial membrane 8A Homo sapiens 111-114 22989452-0 2012 [Effect of Src tyrosine kinase inhibition on the drug-resistance as well as MDR1 and LRP expression of the human cis-platinum-resistant lung cancer cell line A549/DDP]. Cisplatin 113-125 translocase of inner mitochondrial membrane 8A Homo sapiens 163-166 21421285-2 2011 The purpose of this study was to investigate the ability of noscapine to inhibit HIF-1alpha and sensitize ovarian cancer cells to cisplatin (DDP) under hypoxic conditions. Cisplatin 130-139 translocase of inner mitochondrial membrane 8A Homo sapiens 141-144 22490414-1 2012 BACKGROUND: Cisplatin (DDP) is one of most effective and most commonly used therapeutic agent in treating tumors, it can accumulate in the kidney and lead to acute renal failure. Cisplatin 12-21 translocase of inner mitochondrial membrane 8A Homo sapiens 23-26 21823020-6 2011 Then we detected if CpG sequences influenced the TLR9 expression and the sensitivity to cisplatin (DDP) of these cervical cancer cells in vitro. Cisplatin 88-97 translocase of inner mitochondrial membrane 8A Homo sapiens 99-102 21823020-9 2011 Chemosensitivity of the cervical cancer cells to cisplatin (DDP) was measured by MTT. Cisplatin 49-58 translocase of inner mitochondrial membrane 8A Homo sapiens 60-63 21472522-3 2011 Other approaches are based on administration of cross-linking agents, such as cis-diamminedichloroplatinum(II) (cisplatin, DDP), which is still the most widely used anticancer drug worldwide. Cisplatin 78-110 translocase of inner mitochondrial membrane 8A Homo sapiens 123-126 21875463-1 2011 OBJECTIVE: The aim of this study was to investigate the effect of 5-aza-2"-deoxycytidine (5-Aza-dc), a methylation inhibitor, on cisplatin-resistance in non-small cell lung cancer cell line A549/DDP and to explore its possible mechanism. Cisplatin 129-138 translocase of inner mitochondrial membrane 8A Homo sapiens 195-198 21875463-8 2011 CONCLUSIONS: Low dose 5-Aza-dc can partially reverse the cisplatin-resistance in A549/DDP cells, which may be achieved through removal of hMLH1 hypermethylation and increased expression of hMLH1 gene. Cisplatin 57-66 translocase of inner mitochondrial membrane 8A Homo sapiens 86-89 21875463-4 2011 RESULTS: The IC(50) value of cisplatin in A549/DDP cells was 30.15 +- 0.76 micromol/L. Cisplatin 29-38 translocase of inner mitochondrial membrane 8A Homo sapiens 47-50 21397498-4 2011 Only the compounds possessing small substituents (H or CH(3)) at C-6 position showed the same activity as cisplatin (DDP) did. Cisplatin 106-115 translocase of inner mitochondrial membrane 8A Homo sapiens 117-120 20109345-0 2010 Establishment of a cisplatin-induced multidrug resistance cell line SK-Hep1/DDP. Cisplatin 19-28 translocase of inner mitochondrial membrane 8A Homo sapiens 76-79 20572591-2 2010 In the present study we investigated the role of the second mitochondria-derived activator of caspase (Smac/DIABLO) in the action of cisplatin (DDP), 5-fluorouracil (5-FU), and the combination of both in Hep-2 cells. Cisplatin 133-142 translocase of inner mitochondrial membrane 8A Homo sapiens 144-147 20356529-2 2010 METHODS: The proteins of C0C1 and C0C1/DDP were separated by highly sensitive two-dimensional differential gel electrophoresis (2-D DIGE) coupled with matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF-MS) to identify the proteins differentially expressed in cisplatin sensitive and cisplatin resistance cell lines. Cisplatin 278-287 translocase of inner mitochondrial membrane 8A Homo sapiens 39-42 20187799-2 2010 Our aim was to address that question by surveying the autophagic activity in parental lung adenocarcinoma cell line A549 and its 8-fold, more resistant subcell line, A549/DDP, which was obtained by treating cisplatin with increasing concentrations. Cisplatin 207-216 translocase of inner mitochondrial membrane 8A Homo sapiens 171-174 20187799-8 2010 We also found that 3-MA can enhance the growth inhibition and apoptotic effect of cisplatin in acquired resistant cells (A549/DDP). Cisplatin 82-91 translocase of inner mitochondrial membrane 8A Homo sapiens 126-129 20187799-9 2010 Collectively, our results provide evidence that the upregulation of autophagy plays a major role in cisplatin resistance of A549/DDP cells. Cisplatin 100-109 translocase of inner mitochondrial membrane 8A Homo sapiens 129-132 20109345-3 2010 METHODS: SK-Hep1/DDP cell line was induced by pulse treatment using a high concentration of cisplatin (DDP) in vitro. Cisplatin 92-101 translocase of inner mitochondrial membrane 8A Homo sapiens 17-20 20109345-3 2010 METHODS: SK-Hep1/DDP cell line was induced by pulse treatment using a high concentration of cisplatin (DDP) in vitro. Cisplatin 92-101 translocase of inner mitochondrial membrane 8A Homo sapiens 103-106 20356529-2 2010 METHODS: The proteins of C0C1 and C0C1/DDP were separated by highly sensitive two-dimensional differential gel electrophoresis (2-D DIGE) coupled with matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF-MS) to identify the proteins differentially expressed in cisplatin sensitive and cisplatin resistance cell lines. Cisplatin 302-311 translocase of inner mitochondrial membrane 8A Homo sapiens 39-42