PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23397083-7	2013	Moreover, beta-elemene and cisplatin in combination clearly decreased the protein levels of cyclin B1 and CDC25C and increased the levels of p21(Cip1/Waf1), p27(Kip1), and GADD45 in these cells, compared with the effects of either agent alone at the same concentration.	Cisplatin	27-36	cyclin dependent kinase inhibitor 1B	Homo sapiens	161-165	
26213845-0	2015	eIF3a improve cisplatin sensitivity in ovarian cancer by regulating XPC and p27Kip1 translation.	Cisplatin	14-23	cyclin dependent kinase inhibitor 1B	Homo sapiens	76-83	
17602078-5	2007	RESULTS: There was a relationship between p27Kip1 status and benefit of cisplatin-based chemotherapy (test for interaction, P = .02).	Cisplatin	72-81	cyclin dependent kinase inhibitor 1B	Homo sapiens	42-49	
20145152-8	2010	Pre-miR-630 arrested A549 cells in the G0-G1 phase of the cell cycle, correlating with increased levels of the cell cycle inhibitor p27(Kip1) as well as with reduced proliferation rates and resulting in greatly diminished sensitivity of A549 cells to the late S-G2-M cell cycle arrest mediated by CDDP.	Cisplatin	297-301	cyclin dependent kinase inhibitor 1B	Homo sapiens	136-140	
17602078-6	2007	Among patients with p27Kip1-negative tumors, cisplatin-based chemotherapy resulted in longer overall survival compared with controls (adjusted hazard ratio [HR] for death = 0.66; 95% CI, 0.50 to 0.88; P = .006).	Cisplatin	45-54	cyclin dependent kinase inhibitor 1B	Homo sapiens	20-27	
17602078-10	2007	CONCLUSION: NSCLC patients with p27Kip1-negative tumors benefit from adjuvant cisplatin-based chemotherapy after complete tumor resection.	Cisplatin	78-87	cyclin dependent kinase inhibitor 1B	Homo sapiens	32-39	
11734333-6	2002	With cisplatin at a high dose, both cell lines underwent apoptosis that was accompanied by downregulation of p27(KIP1) and Bcl-x(L).	Cisplatin	5-14	cyclin dependent kinase inhibitor 1B	Homo sapiens	113-117	
11593424-7	2001	Induction of p16(Ink4a), p21(Waf1), or p27(Kip1) conferred strong resistance to paclitaxel- or cisplatin-mediated cytotoxicity on the CKI-responsive A431 cells but not on the CKI-unresponsive SiHa cells.	Cisplatin	95-104	cyclin dependent kinase inhibitor 1B	Homo sapiens	43-47	
28658519-0	2017	Synergistic effect of melatonin and ghrelin in preventing cisplatin-induced ovarian damage via regulation of FOXO3a phosphorylation and binding to the p27Kip1 promoter in primordial follicles.	Cisplatin	58-67	cyclin dependent kinase inhibitor 1B	Homo sapiens	151-158	
9688315-7	1998	Transfection-mediated over-expression of p27Kip1 in non-confluent HT29 cells decreases the cytotoxic activity of cisplatin as well as its ability to trigger apoptosis.	Cisplatin	113-122	cyclin dependent kinase inhibitor 1B	Homo sapiens	41-48	
31522610-4	2020	P27Kip1 plays an important role in mediating a cell"s response to cisplatin (CP), a widely used chemotherapeutic cancer drug that induces DNA damage and cell cycle arrest.	Cisplatin	66-75	cyclin dependent kinase inhibitor 1B	Homo sapiens	0-7	
30642385-0	2019	Exosomal miR-196a derived from cancer-associated fibroblasts confers cisplatin resistance in head and neck cancer through targeting CDKN1B and ING5.	Cisplatin	69-78	cyclin dependent kinase inhibitor 1B	Homo sapiens	132-138	
30642385-5	2019	Exosomal miR-196a then binds novel targets, CDKN1B and ING5, to endow HNC cells with cisplatin resistance.	Cisplatin	85-94	cyclin dependent kinase inhibitor 1B	Homo sapiens	44-50	
30642385-9	2019	CONCLUSIONS: The present study finds that CAF-derived exosomal miR-196a confers cisplatin resistance in HNC by targeting CDKN1B and ING5, indicating miR-196a may serve as a promising predictor of and potential therapeutic target for cisplatin resistance in HNC.	Cisplatin	80-89	cyclin dependent kinase inhibitor 1B	Homo sapiens	121-127	
30642385-9	2019	CONCLUSIONS: The present study finds that CAF-derived exosomal miR-196a confers cisplatin resistance in HNC by targeting CDKN1B and ING5, indicating miR-196a may serve as a promising predictor of and potential therapeutic target for cisplatin resistance in HNC.	Cisplatin	233-242	cyclin dependent kinase inhibitor 1B	Homo sapiens	121-127	
28658519-11	2017	Co-administration of melatonin and ghrelin in cisplatin-treated ovaries restored the expression of p27Kip1 , which is critical for retention of the dormant status of primordial follicles.	Cisplatin	46-55	cyclin dependent kinase inhibitor 1B	Homo sapiens	99-106	
27591936-7	2016	miR-196a-5p induction is involved in UCA1 inhibition of apoptosis induced by cisplatin/gemcitabine via targeting p27Kip1.	Cisplatin	77-86	cyclin dependent kinase inhibitor 1B	Homo sapiens	113-120	
27314502-0	2016	Upregulation of p27Kip1 by demethylation sensitizes cisplatin-resistant human ovarian cancer SKOV3 cells.	Cisplatin	52-61	cyclin dependent kinase inhibitor 1B	Homo sapiens	16-23