PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32338107-10 2020 Bioinformatics prediction and western blotting methods validated the targets of miR-181a in vitro.Results: Curcumin treatment alleviated cisplatin-induced nephrotoxicity as validated by the blood urea nitrogen (BUN) values, and histological analysis of kidneys. Cisplatin 137-146 microRNA 181a-2 Mus musculus 80-88 32338107-11 2020 At the molecular level, curcumin treatment decreased miR-181a expression level, which was induced by cisplatin and restored the in vivo expression of PTEN, which was suppressed by cisplatin. Cisplatin 101-110 microRNA 181a-2 Mus musculus 53-61 32338107-11 2020 At the molecular level, curcumin treatment decreased miR-181a expression level, which was induced by cisplatin and restored the in vivo expression of PTEN, which was suppressed by cisplatin. Cisplatin 180-189 microRNA 181a-2 Mus musculus 53-61 32338107-12 2020 We verified the direct regulation of PTEN by miR-181a in cultured human embryonic kidney 293T cells.Conclusions: We showed the involvement of miR-181a/PTEN axis in the renoprotective effect of curcumin against cisplatin-induced AKI, and provide new evidence on the ability of curcumin to alleviate cisplatin-induced nephrotoxicity. Cisplatin 210-219 microRNA 181a-2 Mus musculus 142-150 32338107-12 2020 We verified the direct regulation of PTEN by miR-181a in cultured human embryonic kidney 293T cells.Conclusions: We showed the involvement of miR-181a/PTEN axis in the renoprotective effect of curcumin against cisplatin-induced AKI, and provide new evidence on the ability of curcumin to alleviate cisplatin-induced nephrotoxicity. Cisplatin 298-307 microRNA 181a-2 Mus musculus 142-150 24183997-5 2014 Enforced expression of miR-181a enhanced chemoresistance to cisplatin in cervical cancer cells through apoptosis reversion. Cisplatin 60-69 microRNA 181a-2 Mus musculus 23-31 24183997-6 2014 In a nude mouse xenograft model, the overexpression of miR-181a markedly inhibited the therapeutic response to cisplatin. Cisplatin 111-120 microRNA 181a-2 Mus musculus 55-63 24183997-10 2014 Our findings suggest that miR-181a may function as an oncogene and induce chemoresistance in cervical squamous cell carcinoma cells at least in part by down-regulating PRKCD, thus may provide a biomarker for predicting chemosensitivity to cisplatin in patients with cervical squamous cancer. Cisplatin 239-248 microRNA 181a-2 Mus musculus 26-34