PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32754438-8 2020 The Western blot results showed that the expression of apoptotic proteins cleaved caspase 3 and cleaved PARP in cisplatin-treated A549-LIDM1 and H1299-LIMD1 cells was significantly higher than that in their respective control cells. Cisplatin 112-121 collagen type XI alpha 2 chain Homo sapiens 104-108 33984694-3 2021 The aim of our study was to combine ECT with PARP inhibitor olaparib, which could inhibit the repair of bleomycin or cisplatin induced DNA damage and potentiate the effectiveness of ECT. Cisplatin 117-126 collagen type XI alpha 2 chain Homo sapiens 45-49 32593915-8 2020 Several pre-clinical approaches have proven successful in overcoming cisplatin resistance, including specific targeting of PARP, MDM2 or AKT/mTOR combined with cisplatin. Cisplatin 69-78 collagen type XI alpha 2 chain Homo sapiens 123-127 31938109-7 2018 We also found that the expression of Bcl-2 was increased, and the levels of cleaved caspase-9 and cleaved PARP were reduced after gamma-radiation combined with cisplatin treatment of HeLa-siIER5 cells. Cisplatin 160-169 collagen type XI alpha 2 chain Homo sapiens 106-110 32522234-12 2020 Moreover, knockdown of UNC5B or SIRT4 prohibited CDDP-mediated proteolytic cleavage of PARP and also decreased CDDP sensitivity of these cells. Cisplatin 49-53 collagen type XI alpha 2 chain Homo sapiens 87-91 31905343-6 2020 The combined treatment of aspirin and cisplatin suppressed the expression of the anti-apoptotic protein Bcl-2 and the EMT-related proteins, up-regulated the levels of the cleaved PARP and Bax, and blocked the PI3K/AKT and RAF-MEK-ERK signaling pathway. Cisplatin 38-47 collagen type XI alpha 2 chain Homo sapiens 179-183 31949568-7 2018 Moreover, our results revealed that nuclear beta-catenin was dramatically reduced and cleaved caspase-3 and cleaved PARP were dramatically induced when WNT7A was knocked down in cisplatin treated KB cells. Cisplatin 178-187 collagen type XI alpha 2 chain Homo sapiens 116-120 27419628-5 2016 The results showed that both glutamine deprivation and BPTES pretreatments increased the toxic effects of cisplatin and etoposide on HCC1937 cells, as demonstrated by their reduced proliferation, increased expression of apoptosis-related proteins (cleaved-PARP, cleaved-caspase 9, and cleaved-caspase 3) and decreased Bcl-2/BAX ratio. Cisplatin 106-115 collagen type XI alpha 2 chain Homo sapiens 256-260 28979680-10 2017 After treatment of cisplatin, SKOV3 and hey cells showed increased apoptotic rate in flow cytometry assay, increased protein levels of cleaved caspase 3, cleaved PARP and Bax, and decreased protein levels of Bcl-2 and Bcl-XL. Cisplatin 19-28 collagen type XI alpha 2 chain Homo sapiens 162-166 27689466-10 2017 Moreover, Pretreatment with E2 followed by cisplatin decreased the expression of cleaved PARP, and increased the expression of anti-apoptotic protein Bcl-2. Cisplatin 43-52 collagen type XI alpha 2 chain Homo sapiens 89-93 27591926-3 2016 The combination treatment of cisplatin and resveratrol (CDDP/RSV) synergistically induced apoptosis, as evidenced by typical cell morphological changes, the appearance of sub-G0/G1 peak, an increase in the Annexin V(+) cells and the cleavage of caspase-3 and PARP. Cisplatin 29-38 collagen type XI alpha 2 chain Homo sapiens 259-263 27591926-3 2016 The combination treatment of cisplatin and resveratrol (CDDP/RSV) synergistically induced apoptosis, as evidenced by typical cell morphological changes, the appearance of sub-G0/G1 peak, an increase in the Annexin V(+) cells and the cleavage of caspase-3 and PARP. Cisplatin 56-60 collagen type XI alpha 2 chain Homo sapiens 259-263 28214344-5 2017 Furthermore our results revealed that neferine combined with cisplatin down regulate the expression of Bcl-2 and up regulate the expression of Bax, Bad, Bak, release of cytochrome c, p53 levels, then activated cleavage forms of caspase-9, caspase-3, and PARP. Cisplatin 61-70 collagen type XI alpha 2 chain Homo sapiens 254-258 27823632-13 2016 The combined treatment of sageone and cisplatin markedly reduced Akt expression and phosphorylation, accompanied by increases in cleaved caspase-3, -9 and PARP. Cisplatin 38-47 collagen type XI alpha 2 chain Homo sapiens 155-159 27494891-6 2016 Mechanistic studies suggested that treatment of cells with PHPO or with PHPO + cisplatin differentially inhibited the PI3K/Akt, MAPK and ATM/Chk2 pathways, which consequently suppressed the anti-apoptotic factors Bcl-xL, Bcl-2 and XIAP, but activated the pro-apoptotic factors Bad, Bax, p53, caspase 9, caspase 8, caspase 7 and PARP. Cisplatin 79-88 collagen type XI alpha 2 chain Homo sapiens 328-332 26592553-5 2015 MLN4924 also potentiated the cisplatin-induced apoptosis and activation of caspase-3 and -7, phospho-histone H2A.X and PARP. Cisplatin 29-38 collagen type XI alpha 2 chain Homo sapiens 119-123 27470347-5 2016 Additionally, the expression of active PARP was significantly increased and MMP-9 level was decreased in combination group as compared to the expression seen for the treatment with interferon beta or cisplatin alone. Cisplatin 200-209 collagen type XI alpha 2 chain Homo sapiens 39-43 27470347-6 2016 Results demonstrate that the synergistic inhibitory effects of interferon beta and low dose of cisplatin on human cervical cancer cells and also suggest that the inhibition of NF-kappaB/p-Akt signaling pathway plays a critical role in the anticancer effects of combination treatment along with the induction of PARP. Cisplatin 95-104 collagen type XI alpha 2 chain Homo sapiens 311-315 27186303-7 2016 We also found that the expression of phospho-Akt was reduced, and the levels of cleaved caspase-3 and PARP were increased after the treatment of HepG2/IER5 cells with gamma-irradiation and cisplatin. Cisplatin 189-198 collagen type XI alpha 2 chain Homo sapiens 102-106 26089934-8 2015 Apigenin inhibited caspase-3 activity and PARP cleavage in cisplatin-treated cells. Cisplatin 59-68 collagen type XI alpha 2 chain Homo sapiens 42-46 26193055-3 2015 Pretreatment with erdosteine protects HEI-OC1 cells from cisplatin-medicated apoptosis, which is characterized by increase in nuclear fragmentation, DNA laddering, sub-G0/G1 phase, H2AX phosphorylation, PARP cleavage, and caspase-3 activity. Cisplatin 57-66 collagen type XI alpha 2 chain Homo sapiens 203-207 24973089-8 2014 Increased caspase 3/7 activation and PARP cleavage was observed in C2 cells after cisplatin treatment. Cisplatin 82-91 collagen type XI alpha 2 chain Homo sapiens 37-41 24990093-7 2014 Cisplatin and [Pt(O,O"-acac)(gamma-acac)(DMS)] caused activation of caspases, proteolysis of PARP and modulation of Bcl-2, Bax and Bid. Cisplatin 0-9 collagen type XI alpha 2 chain Homo sapiens 93-97 22983390-11 2012 Furthermore, apoptotic proteins (PARP and caspase-3) and the anti-apoptotic protein Bcl-xL were modulated by the expression level of migfilin in combination with cisplatin. Cisplatin 162-171 collagen type XI alpha 2 chain Homo sapiens 33-37 18824293-4 2009 RAD001 in combination with cisplatin induced a significant increase in the number of apoptotic cells, downregulated the expression of pro-survival molecules, Bcl-2, survivin and cyclinD1, and increased the cleavage of PARP, compared to RAD001 or cisplatin alone. Cisplatin 27-36 collagen type XI alpha 2 chain Homo sapiens 218-222 22665077-6 2012 It was found for the first time that wogonin is able to sensitize cisplatin-induced apoptosis in both A549 cells and HeLa cells as indicated by the potentiation of activation of caspase-3, and cleavage of the caspase-3 substrate PARP in wogonin and cisplatin co-treated cells. Cisplatin 66-75 collagen type XI alpha 2 chain Homo sapiens 229-233 21052098-4 2011 We demonstrated that Ad-ING4 plus CDDP induced synergistic growth inhibition, enhanced apoptosis, and had an additive effect on upregulation of Fas, Bax, Bak, cleaved Bid, cleaved caspase-8, caspase-9, caspase-3 and cleaved PARP, and on downregulation of Bcl-2 and Bcl-X(L) in SMMC-7721 hepatocarcinoma cells. Cisplatin 34-38 collagen type XI alpha 2 chain Homo sapiens 224-228 19578756-5 2009 Both RT4 (grade I; wild-type p53) and T24 (grade III; mutant p53) cell types proved to be vulnerable to cisplatin apoptotic activity, albeit in a grade-dependent and drug dose-specific manner, as demonstrated by the proteolytic processing profiles of Caspase-8, Caspase-9, Caspase-3, and the Caspase repertoire characteristic substrates PARP and Lamin A/C, as well. Cisplatin 104-113 collagen type XI alpha 2 chain Homo sapiens 337-341 22340096-9 2011 The detection of the cleavage of PARP showed that ABT-737 lowered the doses of cisplatin to induce apoptosis and shortened the induction time of apoptosis in T47D cells. Cisplatin 79-88 collagen type XI alpha 2 chain Homo sapiens 33-37 22340096-10 2011 Compared with the single use of cisplatin, the combination of ABT-737 and cisplatin accelerated the cleavage of PARP and caspase3, but did not alter the expression levels of Bcl-2, Bcl-X(L), and Bax. Cisplatin 74-83 collagen type XI alpha 2 chain Homo sapiens 112-116 21516125-3 2011 Here we demonstrate that TAp73alpha over-expression enhanced CDDP-induced PARP cleavage and apoptosis in both chemosensitive (OV2008 and A2780s) and their resistant counterparts (C13* and A2780cp) and another chemoresistant OVCA cells (Hey); in contrast, the effect of DeltaNp73alpha over-expression was variable. Cisplatin 61-65 collagen type XI alpha 2 chain Homo sapiens 74-78 35454385-7 2022 Additional eribulin treatment significantly enhanced PARP cleavage and caspase-3 activity in cisplatin-treated TNBC cells. Cisplatin 93-102 collagen type XI alpha 2 chain Homo sapiens 53-57 17508026-4 2007 The mitogen-activated protein kinase kinase (MEK) inhibitor (U0126) was able to block this effect and reduced cell viability and sensitized cells to cisplatin-induced apoptosis, as shown by PARP cleavage, caspase 3 expression, and annexin-V staining. Cisplatin 149-158 collagen type XI alpha 2 chain Homo sapiens 190-194 17470362-4 2007 Interestingly, the ectopic expression of beta4GalT-II in HeLa cells markedly increased apoptosis and cleavage of PARP induced by cisplatin as well as the expression of pro-apoptotic protein Bax. Cisplatin 129-138 collagen type XI alpha 2 chain Homo sapiens 113-117 15382061-6 2004 Treatment of WM164 melanoma monolayers with 25 microM of cisplatin or RuCl2(KTZ)2 showed that the latter is more effective than cisplatin at inducing PARP fragmentation and proapoptotic Bak expression. Cisplatin 57-66 collagen type XI alpha 2 chain Homo sapiens 150-154 33973461-4 2021 It was found that OPZ alone or in combination with cisplatin can reduce the proliferation of the five types of cancer cells by enhancing the lysis of caspase-3 and PARP and inducing cancer cell apoptosis. Cisplatin 51-60 collagen type XI alpha 2 chain Homo sapiens 164-168 35599471-9 2022 Additionally, increased caspase (caspases-3 and -9) activation and PARP cleavage led to enhanced caspase-dependent apoptosis and improved cisplatin sensitivity. Cisplatin 138-147 collagen type XI alpha 2 chain Homo sapiens 67-71