PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31744897-0	2020	Dual mTORC1/2 inhibition sensitizes testicular cancer models to cisplatin treatment.	Cisplatin	64-73	CREB regulated transcription coactivator 2	Mus musculus	5-13	
32528729-1	2020	Our previous study demonstrated that the mammalian target of rapamycin complex 2 (mTORC2) signaling alleviates renal inflammation and protects against cisplatin-induced AKI.	Cisplatin	151-160	CREB regulated transcription coactivator 2	Mus musculus	82-88	
32508971-8	2020	Cisplatin induced the activation of mTORC1 and mTORC2 and apoptosis in NRK-52E cells, and DZNep inhibited mTORC1 and mTORC2 activity and aggravated cell apoptosis.	Cisplatin	0-9	CREB regulated transcription coactivator 2	Mus musculus	47-53	
33144587-9	2020	MDM2 and mTORC1/2 targeted drugs showed efficacy in the cisplatin sensitive PDX models.	Cisplatin	56-65	CREB regulated transcription coactivator 2	Mus musculus	9-17	
31744897-11	2020	Combined AZD8055 and cisplatin treatment resulted in effective mTORC1/2 inhibition, increased caspase-3 activity, and enhanced tumor growth inhibition.	Cisplatin	21-30	CREB regulated transcription coactivator 2	Mus musculus	63-71	
24840134-7	2014	Targeting of mTORC2 either by kinase inhibitor or rictor knockdown promoted cisplatin-induced apoptosis, but inhibition of mTORC1 either by rapamycin or raptor knockdown did not promote cisplatin-induced apoptosis.	Cisplatin	76-85	CREB regulated transcription coactivator 2	Mus musculus	13-19	
24451322-0	2014	Rictor/mTORC2 protects against cisplatin-induced tubular cell death and acute kidney injury.	Cisplatin	31-40	CREB regulated transcription coactivator 2	Mus musculus	7-13	
24451322-10	2014	Thus, endogenous Rictor/mTORC2 protects against cisplatin-induced AKI, probably mediated by promoting cell survival through Akt signaling activation and induction of autophagy.	Cisplatin	48-57	CREB regulated transcription coactivator 2	Mus musculus	24-30	
23838676-0	2013	A dual mTORC1 and mTORC2 inhibitor shows antitumor activity in esophageal squamous cell carcinoma cells and sensitizes them to cisplatin.	Cisplatin	127-136	CREB regulated transcription coactivator 2	Mus musculus	18-24	
24086535-0	2013	The mTORC2 component rictor contributes to cisplatin resistance in human ovarian cancer cells.	Cisplatin	43-52	CREB regulated transcription coactivator 2	Mus musculus	4-10	
34126157-9	2021	Collectively, the current study identified the implication of Bcl6/BAG5/Rictor-mTORC2 signaling pathway in metabolic reprograming and maintenance of CSC-like features in cisplatin-resistant ovarian cancer cells.	Cisplatin	170-179	CREB regulated transcription coactivator 2	Mus musculus	79-85	
23528835-3	2013	Perifosine and PP242, selective inhibitors of Akt and mTORC1/2, respectively, efficiently suppressed the Akt phosphorylation that was induced by the sustained overexpression of Redd1 and increased the sensitivity of the cells to cisplatin.	Cisplatin	229-238	CREB regulated transcription coactivator 2	Mus musculus	54-62	
22586651-4	2011	reveal an EGFRvIII-mTORC2-NFkappaB signaling cascade and demonstrate that mTORC2 mediates cisplatin resistance through NF-kappaB in an Akt-independent manner in glioblastoma.	Cisplatin	90-99	CREB regulated transcription coactivator 2	Mus musculus	74-80	
35238644-6	2022	Furthermore, selective activation of mTORC2 could protect against hearing loss induced by acoustic trauma and cisplatin-induced ototoxicity.	Cisplatin	110-119	CREB regulated transcription coactivator 2	Mus musculus	37-43