PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17620284-8 2008 Beraprost-mediated protection in a murine model of balloon angioplasty was significantly attenuated by 13S-HODE, a PPARdelta antagonist. 13-hydroxy-9,11-octadecadienoic acid 103-111 peroxisome proliferator activator receptor delta Mus musculus 115-124 17382197-6 2007 In support, oxidized-VLDL and constituents including 13-S-hydroxyoctadecadienoic acid (13-S-HODE) and 4-HNE are PPARbeta/delta ligands. 13-hydroxy-9,11-octadecadienoic acid 53-85 peroxisome proliferator activator receptor delta Mus musculus 112-120 17382197-6 2007 In support, oxidized-VLDL and constituents including 13-S-hydroxyoctadecadienoic acid (13-S-HODE) and 4-HNE are PPARbeta/delta ligands. 13-hydroxy-9,11-octadecadienoic acid 87-96 peroxisome proliferator activator receptor delta Mus musculus 112-120 12909723-0 2003 The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells. 13-hydroxy-9,11-octadecadienoic acid 30-62 peroxisome proliferator activator receptor delta Mus musculus 78-88 12909723-8 2003 Our current study shows that (i) 13-S-HODE binds to PPAR-delta, decreases PPAR-delta activation, and down-regulates PPAR-delta expression in colorectal cancer cells; (ii) the induction of 15-LOX-1 expression is a critical step in NSAID down-regulation of PPAR-delta and the resultant induction of apoptosis; and (iii) PPAR-delta is an important signaling receptor for 13-S-HODE-induced apoptosis. 13-hydroxy-9,11-octadecadienoic acid 33-42 peroxisome proliferator activator receptor delta Mus musculus 52-62 12909723-8 2003 Our current study shows that (i) 13-S-HODE binds to PPAR-delta, decreases PPAR-delta activation, and down-regulates PPAR-delta expression in colorectal cancer cells; (ii) the induction of 15-LOX-1 expression is a critical step in NSAID down-regulation of PPAR-delta and the resultant induction of apoptosis; and (iii) PPAR-delta is an important signaling receptor for 13-S-HODE-induced apoptosis. 13-hydroxy-9,11-octadecadienoic acid 33-42 peroxisome proliferator activator receptor delta Mus musculus 74-84 12909723-8 2003 Our current study shows that (i) 13-S-HODE binds to PPAR-delta, decreases PPAR-delta activation, and down-regulates PPAR-delta expression in colorectal cancer cells; (ii) the induction of 15-LOX-1 expression is a critical step in NSAID down-regulation of PPAR-delta and the resultant induction of apoptosis; and (iii) PPAR-delta is an important signaling receptor for 13-S-HODE-induced apoptosis. 13-hydroxy-9,11-octadecadienoic acid 33-42 peroxisome proliferator activator receptor delta Mus musculus 74-84 12909723-8 2003 Our current study shows that (i) 13-S-HODE binds to PPAR-delta, decreases PPAR-delta activation, and down-regulates PPAR-delta expression in colorectal cancer cells; (ii) the induction of 15-LOX-1 expression is a critical step in NSAID down-regulation of PPAR-delta and the resultant induction of apoptosis; and (iii) PPAR-delta is an important signaling receptor for 13-S-HODE-induced apoptosis. 13-hydroxy-9,11-octadecadienoic acid 33-42 peroxisome proliferator activator receptor delta Mus musculus 74-84 12909723-8 2003 Our current study shows that (i) 13-S-HODE binds to PPAR-delta, decreases PPAR-delta activation, and down-regulates PPAR-delta expression in colorectal cancer cells; (ii) the induction of 15-LOX-1 expression is a critical step in NSAID down-regulation of PPAR-delta and the resultant induction of apoptosis; and (iii) PPAR-delta is an important signaling receptor for 13-S-HODE-induced apoptosis. 13-hydroxy-9,11-octadecadienoic acid 33-42 peroxisome proliferator activator receptor delta Mus musculus 74-84 12909723-10 2003 Our findings indicate that the down-regulation of PPAR-delta by 15-LOX-1 through 13-S-HODE is an apoptotic signaling pathway that is activated by NSAIDs. 13-hydroxy-9,11-octadecadienoic acid 81-90 peroxisome proliferator activator receptor delta Mus musculus 50-60