PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28576825-6 2017 On the basis of a naturally occurring 2"-O-methylated RNA sequence, we performed a systematic permutation of the methylated nucleotide as well as adjacent bases and hereby identify two minimal trinucleotide motifs within a 9-mer oligoribonucleotide that are necessary and sufficient to antagonize TLR7 and TLR8 activation, respectively. hippuric acid 38-42 toll like receptor 7 Homo sapiens 297-301 30102387-4 2018 Previous studies had identified the 2"-O-methylation of guanosine 18 (Gm18) within tRNAs as an antagonist of TLR7 leading to an impaired immune response. hippuric acid 36-40 toll like receptor 7 Homo sapiens 109-113