PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
7836415-1	1995	A novel protein kinase (named PKD) with an NH2-terminal region containing two cysteine-rich motifs has been expressed in COS-7 cells and identified as a receptor for phorbol esters.	Phorbol Esters	166-180	protein kinase D1	Mus musculus	30-33	
10197446-1	1999	The novel mouse serine-threonine kinase protein kinase D (PKD) is activated in intact Swiss 3T3 cells stimulated by phorbol esters, cell permeant diacylglycerols, bryostatin, neuropeptides and growth factors via a phosphorylation-dependent mechanism requiring protein kinase C (PKC) activity.	Phorbol Esters	116-130	protein kinase D1	Mus musculus	40-56	
10197446-1	1999	The novel mouse serine-threonine kinase protein kinase D (PKD) is activated in intact Swiss 3T3 cells stimulated by phorbol esters, cell permeant diacylglycerols, bryostatin, neuropeptides and growth factors via a phosphorylation-dependent mechanism requiring protein kinase C (PKC) activity.	Phorbol Esters	116-130	protein kinase D1	Mus musculus	58-61	
10197446-4	1999	Replacement of serines 744 and 748 with alanine prevented activation of the overexpressed PKD form upon phorbol ester treatment of cells, whereas replacement with glutamic acid results in full constitutive activation.	Phorbol Esters	104-117	protein kinase D1	Mus musculus	90-93	
10197446-6	1999	In vivo 32P-labeling and two-dimensional phosphopeptide mapping of PKD and catalytically inactive PKD mutants at serine 744, 748 or at both residues revealed that phorbol ester-sensitive phosphopeptides could be selectively eliminated from patterns observed as a result of these mutations.	Phorbol Esters	163-176	protein kinase D1	Mus musculus	67-70	
10197446-6	1999	In vivo 32P-labeling and two-dimensional phosphopeptide mapping of PKD and catalytically inactive PKD mutants at serine 744, 748 or at both residues revealed that phorbol ester-sensitive phosphopeptides could be selectively eliminated from patterns observed as a result of these mutations.	Phorbol Esters	163-176	protein kinase D1	Mus musculus	98-101	
11514571-0	2001	Protein kinase D potentiates DNA synthesis and cell proliferation induced by bombesin, vasopressin, or phorbol esters in Swiss 3T3 cells.	Phorbol Esters	103-117	protein kinase D1	Mus musculus	0-16	
9295346-1	1997	Protein kinase D (PKD) is a serine/threonine protein kinase that is activated by phorbol esters via protein kinase C in intact cells.	Phorbol Esters	81-95	protein kinase D1	Mus musculus	0-16	
9295346-1	1997	Protein kinase D (PKD) is a serine/threonine protein kinase that is activated by phorbol esters via protein kinase C in intact cells.	Phorbol Esters	81-95	protein kinase D1	Mus musculus	18-21	
8947045-1	1996	Protein kinase D (PKD) is a serine/threonine protein kinase that is directly stimulated in vitro by phorbol esters and diacylglycerol in the presence of phospholipids.	Phorbol Esters	100-114	protein kinase D1	Mus musculus	0-16	
8947045-1	1996	Protein kinase D (PKD) is a serine/threonine protein kinase that is directly stimulated in vitro by phorbol esters and diacylglycerol in the presence of phospholipids.	Phorbol Esters	100-114	protein kinase D1	Mus musculus	18-21	
8947045-3	1996	Our results demonstrate that tumour-promoting phorbol esters, membrane-permeant diacylglycerol and serum growth factors rapidly induced PKD activation in immortalized cell lines (e.g. Swiss 3T3 and Rat-1 cells), in secondary cultures of mouse embryo fibroblasts and in COS-7 cells transiently transfected with a PKD expression construct.	Phorbol Esters	46-60	protein kinase D1	Mus musculus	136-139	
8947045-3	1996	Our results demonstrate that tumour-promoting phorbol esters, membrane-permeant diacylglycerol and serum growth factors rapidly induced PKD activation in immortalized cell lines (e.g. Swiss 3T3 and Rat-1 cells), in secondary cultures of mouse embryo fibroblasts and in COS-7 cells transiently transfected with a PKD expression construct.	Phorbol Esters	46-60	protein kinase D1	Mus musculus	312-315	
19124542-6	2009	In contrast, the phorbol ester PMA (phorbol-12-myristate-13-acetate, a pharmacological mimic of the downstream mediator diacylglycerol in alpha-adrenergic signalling), caused continuous PKD-dependent HDAC5-GFP nuclear efflux and maintained PKD1-mPlum redistribution.	Phorbol Esters	17-30	protein kinase D1	Mus musculus	186-189	
22311617-9	2012	In addition, PKD2-deficient lymphocytes, as well as DT40 cells devoid of any PKD isoforms, could activate Rap1 in response to B-cell receptor ligation or phorbol ester treatment.	Phorbol Esters	154-167	protein kinase D1	Mus musculus	13-16