PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10527877-1 1999 We found that phorbol ester-primed THP-1 cells (a human monocyte cell line), which express a scavenger receptor, were stimulated by mucins through the macrophage scavenger receptor, resulting in enhanced secretion of IL-1beta. Phorbol Esters 14-27 interleukin 1 beta Homo sapiens 217-225 16026998-2 2005 In the cells activated by the protein kinase C specific phorbol ester (phorbol 12-myristate 13-acetate) and Ca(2+) ionophore (A23187) both adenosine and the subtype-specific receptor agonists, CPA (A1), CGS 21680 (A2A) and IB-MECA (A3) induced a concentration-dependent inhibition of IL-1beta release. Phorbol Esters 56-69 interleukin 1 beta Homo sapiens 284-292 10718382-6 2000 Tolerance is specific for endotoxin, because phorbol ester is still able to activate transcription of the endogenous interleukin 1beta gene and transfected reporter genes. Phorbol Esters 45-58 interleukin 1 beta Homo sapiens 117-134 19753331-9 2009 On the other hand, a strong enhancement of the expression of both receptors by interleukin 1beta, especially in the phorbol ester-differentiated cells, indicates the involvement of kinin receptors in the propagation of the inflammatory processes. Phorbol Esters 116-129 interleukin 1 beta Homo sapiens 79-96 14592852-4 2003 Two weeks after the operation, phorbol ester caused coronary spasm in vivo and coronary hypercontractions in vitro at the IL-1beta-treated segment; both were significantly inhibited by hydroxyfasudil, a specific Rho-kinase inhibitor. Phorbol Esters 31-44 interleukin 1 beta Homo sapiens 122-130 10527877-5 1999 When phorbol ester-primed THP-1 cells were cocultured with colon cancer cells producing mucins, IL-1beta secreted from the THP-1 cells increased significantly. Phorbol Esters 5-18 interleukin 1 beta Homo sapiens 96-104 9920928-2 1999 The lower classic PKC activity on pretreatment with phorbol ester (phorbol 12-myristate 13-acetate (PMA)) for 24 h markedly decreased IL-1beta-induced E-selectin mRNA expression in the presence of fetal calf serum and basic fibroblast growth factor, although the induction of ICAM-1 mRNA expression was only influenced a little by the PKC down-regulation. Phorbol Esters 52-65 interleukin 1 beta Homo sapiens 134-142 10198191-5 1999 IL-1 beta-induced accumulations of VEGF mRNA in cardiac myocytes were abolished by the tyrosine kinase inhibitor genistein, whereas inhibition of protein kinase C (PKC) by staurosporin, calphostin C and phorbol ester-induced PKC depletion, and intracellular Ca2+ chelators did not affect the induction of VEGF mRNA by IL-1 beta. Phorbol Esters 203-216 interleukin 1 beta Homo sapiens 0-9 7473001-4 1995 Similar to BK, two phorbol esters, phorbol 12,13 dibutyrate (PDBu) and phorbol 12-myristate-13-acetate (PMA) which are known to stimulate protein kinase C (PKC), synergistically enhanced the TNF alpha induced IL-1 beta production in the gingival fibroblasts. Phorbol Esters 19-33 interleukin 1 beta Homo sapiens 209-218 9972827-7 1999 Following treatment with interleukin-1beta (IL-1beta), human astrocytes demonstrated increased message and protein expression for MIP-1alpha, while other immune modulators such as interferon-gamma (IFN)-gamma, tumor necrosis factor-alpha (TNF-alpha), granulocyte-macrophage colony-stimulating factor (GM-CSF), lipopolysaccharide, or phorbol ester (a protein kinase C activator) did not induce MIP-1alpha expression in human astrocytes. Phorbol Esters 333-346 interleukin 1 beta Homo sapiens 25-42 9972827-7 1999 Following treatment with interleukin-1beta (IL-1beta), human astrocytes demonstrated increased message and protein expression for MIP-1alpha, while other immune modulators such as interferon-gamma (IFN)-gamma, tumor necrosis factor-alpha (TNF-alpha), granulocyte-macrophage colony-stimulating factor (GM-CSF), lipopolysaccharide, or phorbol ester (a protein kinase C activator) did not induce MIP-1alpha expression in human astrocytes. Phorbol Esters 333-346 interleukin 1 beta Homo sapiens 44-52 9886915-4 1999 Simultaneous application of phorbol ester and Ca2+ ionophore in the absence of IL-1beta mimicked the depolarization caused by IL-1beta. Phorbol Esters 28-41 interleukin 1 beta Homo sapiens 126-134 9218566-0 1997 Dexamethasone potently enhances phorbol ester-induced IL-1beta gene expression and nuclear factor NF-kappaB activation. Phorbol Esters 32-45 interleukin 1 beta Homo sapiens 54-62 7559807-7 1995 Similarly, 5,8,11,14 eicosatetraynoic acid (ETYA), another inhibitor of the arachidonic acid pathway, blocked the induction of transcripts for TNF-alpha, and both IL-1 genes in phorbol ester-stimulated HL 60 cells. Phorbol Esters 177-190 interleukin 1 beta Homo sapiens 163-167 9596483-7 1998 Bryostatin 1 caused a dose-dependent inhibition of the phorbol ester-potentiated IL-1beta response. Phorbol Esters 55-68 interleukin 1 beta Homo sapiens 81-89 8612684-5 1996 Phorbol ester (PMA), a PKC activator, induced stromelysin gene expression, an effect enhanced by the addition of IL-1 beta. Phorbol Esters 0-13 interleukin 1 beta Homo sapiens 113-122 7645620-2 1995 STUDY DESIGN: Secondary cultures of human umbilical vein endothelial cells were grown to confluence and treated with interleukin-1 beta, an array of factors with possible regulatory actions (cytokines, growth factors, vasoactive peptides, and steroids), and a phorbol ester as a stimulatory control. Phorbol Esters 260-273 interleukin 1 beta Homo sapiens 117-135 7480804-7 1995 In contrast to IL-1 beta, treatment with phorbol ester (12-O-tetradecanoyl phorbol-13-acetate, TPA, 10(-10)-10(-6)M) for 24 h significantly inhibited total cellular cPLA2 activity in a concentration-dependent manner. Phorbol Esters 41-54 interleukin 1 beta Homo sapiens 15-24 8340234-7 1993 The role of PKC on HLA-DR-mediated IL-1 beta induction was further confirmed by the ability of SEB to activate PKC on monocytes directly when measured with labeled phorbol ester ([3H]Pbt2)-binding capacity of whole cells. Phorbol Esters 164-177 interleukin 1 beta Homo sapiens 35-44 8083217-12 1994 This regulation is specific for RA: when induced by phorbol ester, IL-1 beta gene expression is also superinduced by cycloheximide but that response is accompanied by enhanced mRNA stability. Phorbol Esters 52-65 interleukin 1 beta Homo sapiens 67-76 8309477-2 1994 Genomic sequences that mediate the induction of human IL-1 beta gene transcription by lipopolysaccharide and phorbol esters are located more than 2,700 bp upstream of the transcriptional start site (cap site). Phorbol Esters 109-123 interleukin 1 beta Homo sapiens 54-63 7512570-7 1994 A protein kinase C-activating phorbol ester, phorbol 12-myristate 13-acetate, and a membrane-permeable diacylglycerol, 1,2-dioctanoyl-glycerol, similarly inhibited the IL-1 beta-induced nitrite production and iNOS mRNA and protein expression, although repetitive additions were needed in the case of diacylglycerol. Phorbol Esters 30-43 interleukin 1 beta Homo sapiens 168-177 8256116-0 1993 Okadaic acid, a phosphatase inhibitor, enhances the phorbol ester-induced interleukin-1 beta expression via an AP-1-mediated mechanism. Phorbol Esters 52-65 interleukin 1 beta Homo sapiens 74-92 8413223-3 1993 Mutation of the NF-kappa B site in the context of the IL-1 beta promoter reduced the responsiveness of the IL-1 beta promoter to various inducers, including phorbol ester, Sendai virus, poly(rI-rC), and IL-1 beta. Phorbol Esters 157-170 interleukin 1 beta Homo sapiens 54-63 8413223-3 1993 Mutation of the NF-kappa B site in the context of the IL-1 beta promoter reduced the responsiveness of the IL-1 beta promoter to various inducers, including phorbol ester, Sendai virus, poly(rI-rC), and IL-1 beta. Phorbol Esters 157-170 interleukin 1 beta Homo sapiens 107-116 8413223-3 1993 Mutation of the NF-kappa B site in the context of the IL-1 beta promoter reduced the responsiveness of the IL-1 beta promoter to various inducers, including phorbol ester, Sendai virus, poly(rI-rC), and IL-1 beta. Phorbol Esters 157-170 interleukin 1 beta Homo sapiens 107-116 8413223-5 1993 When multiple copies of the IL-1 beta NF-kappa B site were linked to an enhancerless simian virus 40 promoter, this element was able to mediate phorbol ester- or lipopolysaccharide-inducible gene expression. Phorbol Esters 144-157 interleukin 1 beta Homo sapiens 28-37 8454038-1 1993 The role of protein tyrosine kinases in the expression of interleukin-1 beta (IL-1 beta) gene in response to phorbol esters (PMA) in THP-1 cell line was investigated. Phorbol Esters 109-123 interleukin 1 beta Homo sapiens 58-76 7681061-6 1993 Phorbol esters induced IL-1 mRNA, suggesting that activation of protein kinase C was responsible for the accumulation of this mRNA. Phorbol Esters 0-14 interleukin 1 beta Homo sapiens 23-27 8454038-1 1993 The role of protein tyrosine kinases in the expression of interleukin-1 beta (IL-1 beta) gene in response to phorbol esters (PMA) in THP-1 cell line was investigated. Phorbol Esters 109-123 interleukin 1 beta Homo sapiens 78-87 1371135-2 1992 After treatment with phorbol ester (PMA) or TNF-alpha, a 20- to 40-fold increase in the level of IL-1 beta mRNA was observed in the HIV-infected PLB-IIIB as compared with the parental PLB-985 cells. Phorbol Esters 21-34 interleukin 1 beta Homo sapiens 97-106 8416817-0 1993 Continuous presence of phorbol ester is required for its IL-1 beta mRNA stabilizing effect. Phorbol Esters 23-36 interleukin 1 beta Homo sapiens 57-66 1382715-7 1992 PMN surviving in response to LPS or IL-1 beta retained the capacity to produce superoxide anion when treated with phorbol esters or fMLP. Phorbol Esters 114-128 interleukin 1 beta Homo sapiens 36-45 1387412-0 1992 Human dermal fibroblast interleukin-1 receptor antagonist (IL-1ra) and interleukin-1 beta (IL-1 beta) mRNA and protein are co-stimulated by phorbol ester: implication for a homeostatic mechanism. Phorbol Esters 140-153 interleukin 1 beta Homo sapiens 71-89 1387412-0 1992 Human dermal fibroblast interleukin-1 receptor antagonist (IL-1ra) and interleukin-1 beta (IL-1 beta) mRNA and protein are co-stimulated by phorbol ester: implication for a homeostatic mechanism. Phorbol Esters 140-153 interleukin 1 beta Homo sapiens 91-100 1387412-8 1992 Similarly, ELISA demonstrated that fibroblast cytoplasmic interleukin-1 receptor antagonist protein and interleukin-1 beta protein were co-stimulated by phorbol ester. Phorbol Esters 153-166 interleukin 1 beta Homo sapiens 104-122 1330055-5 1992 Three different phorbol esters known to activate protein kinase C also synergistically potentiated the action of IL-1 beta on PGE2 formation. Phorbol Esters 16-30 interleukin 1 beta Homo sapiens 113-122 1319762-3 1992 The binding sites appeared to be predominantly type II since phorbol ester treatment of the cells, which selectively downregulates type II IL-1 receptors, reduced binding by 68% while treatment of the cells with an inhibitory monoclonal antibody specific for the type I receptor had no significant effect on IL-1 binding. Phorbol Esters 61-74 interleukin 1 beta Homo sapiens 139-143 1319762-3 1992 The binding sites appeared to be predominantly type II since phorbol ester treatment of the cells, which selectively downregulates type II IL-1 receptors, reduced binding by 68% while treatment of the cells with an inhibitory monoclonal antibody specific for the type I receptor had no significant effect on IL-1 binding. Phorbol Esters 61-74 interleukin 1 beta Homo sapiens 308-312 2171043-8 1990 As the effects of IL-1 beta have been reported to be mimicked by tumour-promoting phorbol esters, this rise in DG suggested the involvement of protein kinase C (PKC). Phorbol Esters 82-96 interleukin 1 beta Homo sapiens 18-27 1646841-2 1991 Both protein kinase C-activating phorbol esters, e.g., PMA, and LPS induce IL-1 beta expression in these cells. Phorbol Esters 33-47 interleukin 1 beta Homo sapiens 75-84 1872919-3 1991 Both probucol and D-alpha-tocopherol inhibit the phorbol ester-induced release of IL-1 beta without altering differentiation. Phorbol Esters 49-62 interleukin 1 beta Homo sapiens 82-91 2789003-4 1989 It was confirmed that two types of H-RS cells, HDLM-1 and KM-H2, can secrete IL-1, especially after treatment with phorbol ester. Phorbol Esters 115-128 interleukin 1 beta Homo sapiens 77-81 2138916-1 1990 The effect of tumor-promoting phorbol ester treatment on the binding of interleukin-1 beta (IL-1 beta) to specific cell surface receptors was investigated. Phorbol Esters 30-43 interleukin 1 beta Homo sapiens 72-90 2138916-1 1990 The effect of tumor-promoting phorbol ester treatment on the binding of interleukin-1 beta (IL-1 beta) to specific cell surface receptors was investigated. Phorbol Esters 30-43 interleukin 1 beta Homo sapiens 92-101 2138916-2 1990 A 1 h exposure of Raji human B lymphoma cells with the protein kinase C-activating phorbol ester, phorbol dibutyrate (PDBu), reduced IL-1 beta binding by up to 90% of control cells. Phorbol Esters 83-96 interleukin 1 beta Homo sapiens 133-142 35140721-6 2022 Moreover, the 3D culture system was more suitable for the observation of neutrophil extracellular traps (NETs) stimulated by the classical stimulation phorbol ester (PMA), and other damage associated molecular patterns (DAMPs) such as Lipopolysaccharide (LPS)/ATP, interleukin-1 beta (IL-1beta) and tumor necrosis factor alpha (TNFalpha) than the 2D culture system. Phorbol Esters 151-164 interleukin 1 beta Homo sapiens 265-283 2553812-5 1989 However, induction of the macrophage phenotype by pretreatment of ML-3 cells with the phorbol ester, PMA, followed by HCMV challenge, resulted in a greatly extended period of expression of IL-1 beta, TNF-alpha, MAD-9, and CSF-1 but not MAD-6 and MAD-2. Phorbol Esters 86-99 interleukin 1 beta Homo sapiens 189-198 3052447-1 1988 Interleukin 1 beta mRNA was induced with phorbol ester, not LPS, in the human histiocytic lymphoma cell line U937, but interleukin 1 alpha mRNA was not induced. Phorbol Esters 41-54 interleukin 1 beta Homo sapiens 0-18 2787167-0 1989 Activation of distinct protein kinase C isozymes by phorbol esters: correlation with induction of interleukin 1 beta gene expression. Phorbol Esters 52-66 interleukin 1 beta Homo sapiens 98-116 2496956-3 1989 We used the phorbol ester/lipopolysaccharide (PMA + LPS) co-induction of IL-1 mRNA and CD13 expression in U937 cells to demonstrate the specificity of the technique. Phorbol Esters 12-25 interleukin 1 beta Homo sapiens 73-77 3052447-2 1988 Nuclear run-on analysis showed that phorbol ester induced the transcription of interleukin 1 beta but did not induce it in the presence of cycloheximide. Phorbol Esters 36-49 interleukin 1 beta Homo sapiens 79-97 3052447-4 1988 Dexamethasone, an immunosuppressive and anti-inflammatory agent, decreased the level of interleukin 1 beta mRNA induced with phorbol ester. Phorbol Esters 125-138 interleukin 1 beta Homo sapiens 88-106 3257575-2 1988 Phorbol ester and lipopolysaccharide increased the steady-state level of IL-1 beta mRNA. Phorbol Esters 0-13 interleukin 1 beta Homo sapiens 73-82 27751866-5 2017 IL-1beta release required priming by phorbol-ester or toll-like receptor stimulation and was prevented by inhibition of K+ efflux, NLRP3 depletion or caspase-1 inhibition, identifying chromium (VI) as a hapten activator of the NLRP3 inflammasome. Phorbol Esters 37-50 interleukin 1 beta Homo sapiens 0-8 3494766-9 1987 In contrast to the actions of LT or TNF, pretreatment with IL 1 alpha or IL 1 beta only partially inhibited induction of H4/18 binding by phorbol ester, and phorbol ester pretreatment consistently, albeit partially, inhibited induction by IL 1 species. Phorbol Esters 138-151 interleukin 1 beta Homo sapiens 73-82 28057759-4 2017 We show that abacavir fails to generate direct innate immune activation in human monocytes but potently triggers IL-1beta release upon pro-inflammatory priming with phorbol ester or Toll-like receptor stimulation. Phorbol Esters 165-178 interleukin 1 beta Homo sapiens 113-121